Peer-reviewed Articles - Medicine

22 downloads
71 views

Background Publication bias is the tendency of investigators, reviewers, and editors to submit or accept manuscripts for publication based on their direction or strength of findings. In this study, we investigated if publication bias was present in gastroenterological...

["Epidemiology","Evidence Based Medicine","Gastroenterology and Hepatology"]
doi:10.7717/peerj.4995
49 downloads
332 views

A robust and accurate gene expression signature is essential to assist oncologists to determine which subset of patients at similar Tumor-Lymph Node-Metastasis (TNM) stage has high recurrence risk and could benefit from adjuvant therapies. Here we applied a two-step...

["Bioinformatics","Gastroenterology and Hepatology","Oncology","Data Mining and Machine Learning"]
doi:10.7717/peerj.4942
1 citation
39 downloads
208 views

Background Fetuin-A and leukocyte cell-derived chemotaxin-2 (LECT-2) are liver-derived proteins. Fetuin-A is an independent risk factor for type 2 diabetes (T2D) and obese patients with T2D have higher plasma fetuin-A levels than those without T2D. LECT-2 has positive...

["Gastroenterology and Hepatology","Nutrition","Surgery and Surgical Specialties","Metabolic Sciences"]
doi:10.7717/peerj.4884
34 downloads
267 views

Background Constipation is suspected to occur frequently after acquired brain injury (ABI). In patients with ABI, heart rate variability (HRV) is reduced suggesting autonomic dysfunction. Autonomic dysfunction may be associated with prolonged gastrointestinal transit...

["Gastroenterology and Hepatology","Neurology"]
doi:10.7717/peerj.4912
32 downloads
241 views

Background Hepatocellular carcinoma (HCC) is the most common and aggressive type of malignant liver tumor. HCC progression depends significantly on its vascularization and formation of new blood vessels. Vascular endothelial growth factor A (VEGFA) is a crucial...

["Molecular Biology","Gastroenterology and Hepatology","Oncology"]
doi:10.7717/peerj.4915
60 downloads
743 views

Background Fecal Microbiota Transplantation (FMT) is an innovative means of treating recurrent Clostridium difficile infection (rCDI), through restoration of gut floral balance. However, there is a lack of data concerning the efficacy of FMT and its impact on the...

["Microbiology","Gastroenterology and Hepatology","Infectious Diseases","Pediatrics","Translational Medicine"]
doi:10.7717/peerj.4663
59 downloads
329 views

Sorting nexin-1 (SNX1) is an important functional protein in cell endocytosis, efflux, protein sorting, cell signal transduction, etc; however, the expression, the role and clinical relevance of SNX1 have not been investigated in gastric cancer (GC). In this study,...

["Gastroenterology and Hepatology","Oncology","Histology"]
doi:10.7717/peerj.4829
39 downloads
177 views

Objectives The prognosis of people with pancreatic cancer is extremely unfavorable. However, the prognostic factors remain largely undefined. We aimed to perform comprehensive analyses of clinicopathologic characteristics, laboratory parameters, and treatment protocols...

["Gastroenterology and Hepatology","Oncology"]
doi:10.7717/peerj.4893
1,843 downloads
335 views

Background The annual global deaths from viral hepatitis is 1.4 million. Pakistan has the second highest burden of hepatitis C in the world. There is dire need to evaluate the response of new direct acting antivirals for the treatment of hepatitis C patients in...

["Virology","Gastroenterology and Hepatology"]
doi:10.7717/peerj.4853
94 downloads
442 views

Backgrounds and Aims Melanosis coli (MC) is a noninflammatory, benign, and reversible colonic disorder, but its detection rates in China are unclear. We therefore aimed to analyze the epidemiological characteristics of MC in China. Methods We assessed the detection...

["Epidemiology","Evidence Based Medicine","Gastroenterology and Hepatology","Pathology"]
doi:10.7717/peerj.4483
70 downloads
391 views

Purpose This study was performed to investigate the expression pattern of Wnt inhibitory factor 1 (Wif1) and β-catenin during anorectal development in normal and anorectal malformation (ARM) embryos and the possible role of Wif1 and β-catenin in the pathogenesis...

["Developmental Biology","Gastroenterology and Hepatology","Pediatrics"]
doi:10.7717/peerj.4445
126 downloads
708 views

Background In this study, the long-term efficacy of hepatitis B virus (HBV) vaccination was assessed using seroprevalence and an age–period–cohort (APC) model of HBV seromarkers among university entrants 30 years after the introduction of the national neonatal...

["Epidemiology","Gastroenterology and Hepatology","Global Health","Infectious Diseases","Public Health"]
doi:10.7717/peerj.4297
1 citation
120 downloads
873 views

Liver fibrosis is a disease that causes high morbidity and has become a major health problem. Liver fibrosis can lead to the end stage of liver diseases (livercirrhosisand hepatocellularcarcinoma). Currently, liver transplantation is the only effective treatment...

["Cell Biology","Gastroenterology and Hepatology","Translational Medicine"]
doi:10.7717/peerj.4336
119 downloads
476 views

Objectives To investigate the frequency and prognostic role of deficient mismatch repair (dMMR) and RAS mutation in Chinese patients with colorectal carcinoma. Methods Clinical and pathological information from 813 patients were reviewed and recorded. Expression...

["Gastroenterology and Hepatology","Oncology","Pathology","Medical Genetics"]
doi:10.7717/peerj.4341
121 downloads
579 views

Background Equine metabolic syndrome (EMS) is associated with insulin dysregulation, which often manifests as post-prandial hyperinsulinemia. Circulating concentrations of the incretin hormone, glucagon-like peptide-1 (GLP-1) correlate with an increased insulin...

["Veterinary Medicine","Diabetes and Endocrinology","Gastroenterology and Hepatology"]
doi:10.7717/peerj.4316

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