Peer-reviewed Articles - Medicine

28 downloads
130 views

Background Understanding hub genes involved in gastric cancer (GC) metastasis could lead to effective approaches to diagnose and treat cancer. In this study, we aim to identify the hub genes and investigate the underlying molecular mechanisms of GC. Methods To...

["Bioinformatics","Gastroenterology and Hepatology"]
doi:10.7717/peerj.6092
20 downloads
138 views

Background Colorectal cancer remains a serious public health problem due to the poor prognosis. In the present study, we attempted to develop and validate a prognostic signature to predict the individual mortality risk in colorectal cancer patients. Materials and...

["Bioinformatics","Molecular Biology","Gastroenterology and Hepatology","Oncology"]
doi:10.7717/peerj.6061
46 downloads
236 views

Background A strict gluten-free (GF) diet is required for the management of celiac disease (CD). The nutritional adequacy of this diet has been questioned due to the elimination of wheat, an important vehicle for micronutrient fortification and source of fibre....

["Food Science and Technology","Gastroenterology and Hepatology","Nutrition"]
doi:10.7717/peerj.5875
60 downloads
234 views

Colorectal cancer ranks third among the most commonly diagnosed cancers in the United States. Current therapies have a range of side effects, and the development of a reliable animal model to speed the discovery of safe effective preventative therapies would be...

["Gastroenterology and Hepatology","Oncology"]
doi:10.7717/peerj.5602
43 downloads
258 views

Background Anorectal malformations (ARMs) are the most common congenital malformation of the gut, and regulated by multiple signal transduction pathways. The microRNA (miRNA) expression profiles and their biologial functions in anorectal malformations (ARMs) remain...

["Bioinformatics","Gastroenterology and Hepatology","Pediatrics"]
doi:10.7717/peerj.5774
57 downloads
213 views

Objective To investigate the interaction of non-coding RNAs (ncRNAs) in hepatocellular carcinoma. Methods We compared the ncRNAs and mRNAs expression profiles of hepatocellular carcinoma and adjacent tissue by microarray and RT-PCR. The relationship between different...

["Gastroenterology and Hepatology","Oncology","Surgery and Surgical Specialties"]
doi:10.7717/peerj.5787
68 downloads
247 views

Introduction The present study investigated the crucial role of inflammation-based prognostic scores in locally advanced cervical esophageal squamous cell carcinoma (ESCC) patients who underwent curative concurrent chemoradiotherapy (CCRT). Methods There were 411...

["Gastroenterology and Hepatology","Oncology"]
doi:10.7717/peerj.5655
66 downloads
289 views

Background Abnormal methylation of TNFRSF10C was found to be associated with different types of cancers, excluding colorectal cancer (CRC). In this paper, the performance of TNFRSF10C methylation in CRC was studied in two stages. Method The discovery stage was...

["Biochemistry","Genetics","Molecular Biology","Gastroenterology and Hepatology","Oncology"]
doi:10.7717/peerj.5336
46 downloads
204 views

Background and Aims To prospectively evaluate the effects of antiviral therapy on liver hemodynamics in patients with hepatitis B cirrhosis. Methods Seventy consecutive eligible HBV-related cirrhotic inpatients were enrolled in the prospective study. Fifty-two...

["Gastroenterology and Hepatology","Radiology and Medical Imaging"]
doi:10.7717/peerj.5484
52 downloads
249 views

Some plants popularly employed for the treatment of peptic ulcers have proved to be attractive sources of new drugs. Despite extensive research, the pharmacological and toxicological potentials of these plants are not fully understood. In this context, the aim...

["Plant Science","Drugs and Devices","Gastroenterology and Hepatology"]
doi:10.7717/peerj.5375
68 downloads
381 views

Background Except for a few studies with contradictory observations, information is lacking on the possibility of association between DNA mismatch repair (MMR) status and the presence of cancer stem cells in colorectal carcinoma (CRC), two important aspects in...

["Gastroenterology and Hepatology","Pathology"]
doi:10.7717/peerj.5530
94 downloads
383 views

Background Intra-abdominal adhesions develop after nearly every abdominal surgery, commonly causing female infertility, chronic pelvic pain, and small bowel obstruction. Pentoxifylline (PTX) is a methylxanthine compound with immunomodulatory and antifibrotic properties....

["Drugs and Devices","Gastroenterology and Hepatology","Surgery and Surgical Specialties"]
doi:10.7717/peerj.5434
126 downloads
423 views

Objective The mechanism underlying colon cancer metastasis remain unclear. This study aimed to elucidate the genes alteration during the metastasis of colon cancer and identify genes that crucial to the metastasis and survival of colon cancer patients. Methods...

["Gastroenterology and Hepatology","Oncology"]
doi:10.7717/peerj.5433
315 downloads
940 views

Objectives To comprehensively analyse the global scientific outputs of hepatocellular carcinoma (HCC) research. Methods Data of publications were downloaded from the Web of Science Core Collection. We used CiteSpace IV and Excel 2016 to analyse literature information,...

["Gastroenterology and Hepatology","Oncology","Statistics"]
doi:10.7717/peerj.5477
248 downloads
1,037 views

The beneficial effects of prebiotic fibres on human health have been related to their capacities to alter the gut microbiota and modify the growth of beneficial microorganisms. It is long appreciated that bacterial metabolites affect the host’s physiology. The...

["Cell Biology","Food Science and Technology","Microbiology","Gastroenterology and Hepatology","Nutrition"]
doi:10.7717/peerj.5288

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