Peer-reviewed Articles - Medicine

54 downloads
308 views

GDF11, a member of TGF-β superfamily, has recently received widespread attention as a novel anti-ageing/rejuvenation factor to reverse age-related dysfunctions in heart and skeletal muscle, and to induce angiogenesis and neurogenesis. However, these positive effects...

["Biochemistry","Bioinformatics","Cell Biology","Neuroscience","Evidence Based Medicine"]
doi:10.7717/peerj.5524
287 downloads
8,236 views

Background Blinding is critical to clinical trials because it allows for separation of specific intervention effects from bias, by equalising all factors between groups except for the proposed mechanism of action. Absent or inadequate blinding in clinical trials...

["Anesthesiology and Pain Management","Clinical Trials","Evidence Based Medicine"]
doi:10.7717/peerj.5318
264 downloads
2,971 views

Background Insomnia is common. However, no systematic reviews have examined the effect of exercise on patients with primary and secondary insomnia, defined as both sleep disruption and daytime impairment. This systematic review and meta-analysis aimed to examine...

["Epidemiology","Evidence Based Medicine","Psychiatry and Psychology","Statistics"]
doi:10.7717/peerj.5172
116 downloads
980 views

Background Age and breed are considered the greatest risk factors for disease prevalence and mortality in companion dogs. Understanding the prevalence of diseases, in relation to age and breed, would support appropriate guidance for future health care strategies...

["Veterinary Medicine","Epidemiology","Evidence Based Medicine"]
doi:10.7717/peerj.5161
184 downloads
966 views

Background Obesity is a key public health problem. The advancement of gut microbiota research sheds new light on this field. This article aims to present the research trends in global intestinal microbiota studies within the domain of obesity research. Methods...

["Evidence Based Medicine","Gastroenterology and Hepatology","Global Health","Data Mining and Machine Learning","Data Science"]
doi:10.7717/peerj.5091
84 downloads
387 views

Background Publication bias is the tendency of investigators, reviewers, and editors to submit or accept manuscripts for publication based on their direction or strength of findings. In this study, we investigated if publication bias was present in gastroenterological...

["Epidemiology","Evidence Based Medicine","Gastroenterology and Hepatology"]
doi:10.7717/peerj.4995
2 citations
242 downloads
1,230 views

Objective To systematically review the efficacy of psychological, pharmacological, and combined treatments for binge eating disorder (BED). Method Systematic search and meta-analysis. Results We found 45 unique studies with low/medium risk of bias, and moderate...

["Evidence Based Medicine","Psychiatry and Psychology"]
doi:10.7717/peerj.5113
1 citation
134 downloads
1,989 views

Background There is a lack of research considering acute fatigue responses to high- and low-load resistance training as well as the comparison between male and female responses. Furthermore, limited studies have considered fatigue response testing with the inclusion...

["Anatomy and Physiology","Evidence Based Medicine","Health Policy","Public Health"]
doi:10.7717/peerj.4523
150 downloads
633 views

Backgrounds and Aims Melanosis coli (MC) is a noninflammatory, benign, and reversible colonic disorder, but its detection rates in China are unclear. We therefore aimed to analyze the epidemiological characteristics of MC in China. Methods We assessed the detection...

["Epidemiology","Evidence Based Medicine","Gastroenterology and Hepatology","Pathology"]
doi:10.7717/peerj.4483
715 downloads
8,802 views

Background Impaired patient-reported shoulder function and pain, external-rotation strength, abduction strength, and abduction range-of-motion (ROM) is reported in patients with subacromial impingement (SIS). However, it is unknown how much strength and ROM improves...

["Evidence Based Medicine","Kinesiology","Orthopedics","Surgery and Surgical Specialties"]
doi:10.7717/peerj.4400
148 downloads
1,138 views

Background Advanced treatment of oral cancer increases survival rates; however, it also increases the risk of developing shoulder dysfunction, dysphagia, oral dysfunction, donor site morbidity and psychological issues. This single-arm preliminary pilot study aims...

["Clinical Trials","Evidence Based Medicine","Oncology"]
doi:10.7717/peerj.4419
260 downloads
863 views

Background Glycine air polishing has been proved to be safe, comfortable and time-saving. Whether it could substitute ultrasonic scaling to remove dental plaque biofilm during periodontal maintenance remains unclear. The purposes of this study were to evaluate...

["Microbiology","Clinical Trials","Dentistry","Drugs and Devices","Evidence Based Medicine"]
doi:10.7717/peerj.4371
176 downloads
641 views

Background Acute respiratory failure (ARF) is a life-threatening complication in patients with community acquired pneumonia (CAP). The use of non-invasive ventilation is controversial. With this prospective, observational study we aimed to describe a protocol to...

["Evidence Based Medicine","Global Health","Infectious Diseases","Public Health","Respiratory Medicine"]
doi:10.7717/peerj.4211
1 citation
130 downloads
789 views

Dengue is endemic throughout tropical and subtropical regions of the world. Currently, there is no clinically approved therapeutic drug available for this acute viral infection. Although the first dengue vaccine Dengvaxia has been approved for use in certain countries,...

["Molecular Biology","Evidence Based Medicine","Infectious Diseases"]
doi:10.7717/peerj.3939
1,744 downloads
6,879 views

Background Low back pain clinical practice guidelines consistently recommend against the routine ordering of spinal imaging; however, imaging is frequently requested in primary care, without evidence of benefit. Imaging reports frequently identify degenerative...

["Evidence Based Medicine","Orthopedics","Radiology and Medical Imaging","Rheumatology"]
doi:10.7717/peerj.4151

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