Peer-reviewed Articles - Medicine

9 downloads
73 views

The classical way of defining enzyme inhibition has obscured the distinction between inhibitory effect and the inhibitor binding constant. This article examines the relationship between the simple binding curve used to define biomolecular interactions and the standard...

["Biochemistry","Computational Biology","Mathematical Biology","Drugs and Devices","Pharmacology"]
doi:10.7717/peerj.6082
30 downloads
198 views

Background Several technology-assisted aids are available to help blind and visually impaired people perform their daily activities. The current research uses the state-of-the-art technology to enhance the utility of traditional navigational aids to produce solutions...

["Drugs and Devices","Ophthalmology","Human\u2013Computer Interaction","Data Mining and Machine Learning"]
doi:10.7717/peerj.6058
30 downloads
202 views

Background Mesenchymal stem/stromal cells (MSCs) are a promising tool for cell-based therapies in the treatment of tissue injury. The stromal cell-derived factor-1 (SDF-1)/CXC chemokine receptor 4 (CXCR4) axis plays a significant role in directing MSC homing to...

["Cell Biology","Mathematical Biology","Drugs and Devices"]
doi:10.7717/peerj.6072
70 downloads
377 views

Background Multimorbidity presents an increasingly common problem in older population, and is tightly related to polypharmacy, i.e., concurrent use of multiple medications by one individual. Detecting polypharmacy from drug prescription records is not only related...

["Drugs and Devices","Public Health","Statistics","Computational Science"]
doi:10.7717/peerj.5765
56 downloads
277 views

Background Prescription pain reliever (PPR) overdoses differentially affect ‘American Indian/Alaskan Natives’ in the United States (US). Here, studying onset of extra-medical PPR use in 12-24-year-olds, we examine subgroup variations in rates of starting to use...

["Drugs and Devices","Epidemiology","Public Health"]
doi:10.7717/peerj.5713
103 downloads
389 views

Background Acetylsalicylic acid was renamed aspirin in 1899, and it has been widely used for its multiple biological actions. Because of the diversity of the cellular processes and diseases that aspirin reportedly affects and benefits, uncertainty remains regarding...

["Bioinformatics","Drugs and Devices","Oncology"]
doi:10.7717/peerj.5667
52 downloads
249 views

Some plants popularly employed for the treatment of peptic ulcers have proved to be attractive sources of new drugs. Despite extensive research, the pharmacological and toxicological potentials of these plants are not fully understood. In this context, the aim...

["Plant Science","Drugs and Devices","Gastroenterology and Hepatology"]
doi:10.7717/peerj.5375
94 downloads
383 views

Background Intra-abdominal adhesions develop after nearly every abdominal surgery, commonly causing female infertility, chronic pelvic pain, and small bowel obstruction. Pentoxifylline (PTX) is a methylxanthine compound with immunomodulatory and antifibrotic properties....

["Drugs and Devices","Gastroenterology and Hepatology","Surgery and Surgical Specialties"]
doi:10.7717/peerj.5434
145 downloads
347 views

Background Nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently used in clinical practice, which can have adverse effects on the osteoblast. The objective of this study was to determine the effect of NSAIDs on the osteoblast by analyzing the gene expression...

["Drugs and Devices","Pharmacology"]
doi:10.7717/peerj.5415
2 citations
207 downloads
845 views

The present study comprises the synthesis of a new series of sulfonamides derived from 4-methoxyphenethylamine (1). The synthesis was initiated by the reaction of 1 with 4-methylbenzenesulfonyl chloride (2) in aqueous sodium carbonate solution at pH 9 to yield...

["Bioinformatics","Neuroscience","Cognitive Disorders","Drugs and Devices"]
doi:10.7717/peerj.4962
100 downloads
559 views

Thymidylate synthase (TS, E.C. 2.1.1.45) is a crucial enzyme for de novo deoxythymidine monophosphate (dTMP) biosynthesis. The gene for this enzyme is thyA, which encodes the folate-dependent TS that converts deoxyuridine monophosphate group (dUMP) into (dTMP)...

["Aquaculture, Fisheries and Fish Science","Biochemistry","Marine Biology","Microbiology","Drugs and Devices"]
doi:10.7717/peerj.5023
1 citation
133 downloads
618 views

Candidemia and other forms of invasive fungal infections caused by Candida glabrata and to a lesser extent Saccharomyces cerevisiae are a serious health problem, especially if their steadily rising resistance to the limited range of antifungal drugs is taken into...

["Microbiology","Drugs and Devices","Infectious Diseases","Public Health"]
doi:10.7717/peerj.4999
112 downloads
605 views

Background We sought to determine the effects of unilateral lower-limb external pneumatic compression (EPC) on bilateral lower-limb vascular reactivity and skin blood flow. Methods Thirty-two participants completed this two-aim study. In AIM1 (n = 18, age: 25.5 ± 4.7...

["Anatomy and Physiology","Drugs and Devices","Kinesiology"]
doi:10.7717/peerj.4878
2 citations
159 downloads
805 views

Many infectious diseases disproportionately affect people in the developing world. Cryptococcal meningitis is one of the most common mycoses in HIV-AIDS patients, with the highest burden of disease in sub-Saharan Africa. Current best treatment regimens still result...

["Microbiology","Mycology","Drugs and Devices","Infectious Diseases"]
doi:10.7717/peerj.4761
1 citation
166 downloads
721 views

Background Beyond its traditional uses in the Balkan area, Sideritis scardica (known as Greek mountain tea, Lamiaceae) is currently extensively investigated for its pharmacological activity in the central nervous system. Antidepressant, psychostimulating, cognition-enhancing...

["Cognitive Disorders","Drugs and Devices","Pharmacology"]
doi:10.7717/peerj.4683

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