Peer-reviewed Articles - Medicine

30 downloads
248 views

Thymidylate synthase (TS, E.C. 2.1.1.45) is a crucial enzyme for de novo deoxythymidine monophosphate (dTMP) biosynthesis. The gene for this enzyme is thyA, which encodes the folate-dependent TS that converts deoxyuridine monophosphate group (dUMP) into (dTMP)...

["Aquaculture, Fisheries and Fish Science","Biochemistry","Marine Biology","Microbiology","Drugs and Devices"]
doi:10.7717/peerj.5023
33 downloads
174 views

Candidemia and other forms of invasive fungal infections caused by Candida glabrata and to a lesser extent Saccharomyces cerevisiae are a serious health problem, especially if their steadily rising resistance to the limited range of antifungal drugs is taken into...

["Microbiology","Drugs and Devices","Infectious Diseases","Public Health"]
doi:10.7717/peerj.4999
35 downloads
297 views

Background We sought to determine the effects of unilateral lower-limb external pneumatic compression (EPC) on bilateral lower-limb vascular reactivity and skin blood flow. Methods Thirty-two participants completed this two-aim study. In AIM1 (n = 18, age: 25.5 ± 4.7...

["Anatomy and Physiology","Drugs and Devices","Kinesiology"]
doi:10.7717/peerj.4878
93 downloads
442 views

Many infectious diseases disproportionately affect people in the developing world. Cryptococcal meningitis is one of the most common mycoses in HIV-AIDS patients, with the highest burden of disease in sub-Saharan Africa. Current best treatment regimens still result...

["Microbiology","Mycology","Drugs and Devices","Infectious Diseases"]
doi:10.7717/peerj.4761
86 downloads
350 views

Background Beyond its traditional uses in the Balkan area, Sideritis scardica (known as Greek mountain tea, Lamiaceae) is currently extensively investigated for its pharmacological activity in the central nervous system. Antidepressant, psychostimulating, cognition-enhancing...

["Cognitive Disorders","Drugs and Devices","Pharmacology"]
doi:10.7717/peerj.4683
144 downloads
526 views

Background Polyhexamethylene biguanide (PHMB) eye drops are a frequently used medication to treat Acanthamoeba keratitis. In the absence of marketed PHMB eye drops, pharmacy-compounding units are needed to prepare this much needed treatment, but the lack of validated...

["Drugs and Devices","Ophthalmology"]
doi:10.7717/peerj.4549
439 downloads
2,141 views

Background Flexible pes planus (flat feet) in children is a common reason parents and caregivers seek health professionals consult and a frequent reason podiatrists prescribe foot orthoses. Yet no universal agreement exists on the diagnosis of this condition, or...

["Drugs and Devices","Kinesiology","Pediatrics"]
doi:10.7717/peerj.4667
236 downloads
644 views

Background Several field studies have used fuel-cell breathalysers (FCB) to investigate the prevalence of alcohol intoxication. However, there is a lack of evidence evaluating the psychometric properties of these breathalysers outside of the forensic disciplines....

["Drugs and Devices","Public Health"]
doi:10.7717/peerj.4418
106 downloads
528 views

The structure-thermodynamics correlation analysis was performed for a series of fluorine- and chlorine-substituted benzenesulfonamide inhibitors binding to several human carbonic anhydrase (CA) isoforms. The total of 24 crystal structures of 16 inhibitors bound...

["Biophysics","Drugs and Devices"]
doi:10.7717/peerj.4412
149 downloads
570 views

Background Glycine air polishing has been proved to be safe, comfortable and time-saving. Whether it could substitute ultrasonic scaling to remove dental plaque biofilm during periodontal maintenance remains unclear. The purposes of this study were to evaluate...

["Microbiology","Clinical Trials","Dentistry","Drugs and Devices","Evidence Based Medicine"]
doi:10.7717/peerj.4371
144 downloads
545 views

Background Bedside non-invasive techniques, such as radial artery tonometry, to estimate hemodynamic parameters have gained increased relevance as an attractive alternative and efficient method to measure hemodynamics in outpatient departments. For our pilot study,...

["Cardiology","Drugs and Devices"]
doi:10.7717/peerj.4132
227 downloads
963 views

Background Streptomyces are well known for their capability to produce many bioactive secondary metabolites with medical and industrial importance. Here we report a novel bioactive phenazine compound, 6-((2-hydroxy-4-methoxyphenoxy) carbonyl) phenazine-1-carboxylic...

["Bioinformatics","Biotechnology","Genomics","Drugs and Devices"]
doi:10.7717/peerj.3738
338 downloads
1,069 views

The expression of carbonic anhydrase (CA) IX is up-regulated in many types of solid tumors in humans under hypoxic and acidic microenvironment. Inhibition of CA IX enzymatic activity with selective inhibitors, antibodies or labeled probes has been shown to reverse...

["Biochemistry","Biophysics","Drugs and Devices"]
doi:10.7717/peerj.4068
1 citation
318 downloads
1,726 views

Introduction The repurposing of non-antibiotic drugs as adjuvant antibiotics may help break antimicrobial resistance (AMR). Statins are commonly prescribed worldwide to lower cholesterol. They also possess qualities of AMR “breakers”, namely direct antibacterial...

["Microbiology","Drugs and Devices","Global Health","Infectious Diseases","Pharmacology"]
doi:10.7717/peerj.3952
111 downloads
1,419 views

Background Dual energy X-ray absorptiometry (DXA) is a commonly used instrument for analysing segmental body composition (BC). The information from the scan guides the clinician in the treatment of conditions such as obesity and can be used to monitor recovery...

["Drugs and Devices","Epidemiology","Kinesiology","Nutrition","Radiology and Medical Imaging"]
doi:10.7717/peerj.3880

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