Peer-reviewed Articles - Medicine

6 citations
486 downloads
1,963 views

Substantial evidence has shown that most exogenous substances are metabolized by multiple cytochrome P450 (P450) enzymes instead of by merely one P450 isoform. Thus, multi-P450 inhibition leads to greater drug-drug interaction risk than specific P450 inhibition....

["Computational Biology","Drugs and Devices","Pharmacology"]
doi:10.7717/peerj.1524
10 citations
1,036 downloads
1,859 views

Current ovarian cancer treatment involves chemotherapy that has serious limitations, such as rapid clearance, unfavorable biodistribution and severe side effects. To overcome these limitations, drug delivery systems (DDS) have been developed to encapsulate chemotherapeutics...

["Drugs and Devices","Gynecology and Obstetrics","Oncology"]
doi:10.7717/peerj.1489
9 citations
444 downloads
1,514 views

The most described techniques used to detect diabetic retinopathy and diabetic macular edema have to be interpreted correctly, such that a person not specialized in ophthalmology, as is usually the case of a primary care physician, may experience difficulties with...

["Diabetes and Endocrinology","Drugs and Devices","Epidemiology","Human-Computer Interaction","Ophthalmology"]
doi:10.7717/peerj.1404
1 citation
398 downloads
1,617 views

Context. During the late 1990s, insecticide resistance had rendered a number of treatment products ineffective; some companies saw this as an opportunity to develop alternative types of treatment. We investigated the possibility that a surfactant-based lotion containing...

["Clinical Trials","Dermatology","Drugs and Devices","Nursing","Public Health"]
doi:10.7717/peerj.1368
4 citations
403 downloads
1,814 views

Hepatic stellate cells (HSCs) activation is essential to the pathogenesis of liver fibrosis. Exploring drugs targeting HSC activation is a promising anti-fibrotic strategy. In the present study, we found suberoylanilide hydroxamic acid (SAHA), a histone deacetylase...

["Cell Biology","Molecular Biology","Drugs and Devices","Gastroenterology and Hepatology"]
doi:10.7717/peerj.1362
8 citations
432 downloads
2,414 views

Background. When 12-to-21-year-olds start using prescription pain relievers extra-medically, some of them transition into opioid dependence within 12 months after such use. Our main aim for this epidemiological research on 12-to-21-year-olds in the United States...

["Drugs and Devices","Epidemiology","Public Health"]
doi:10.7717/peerj.1340
9 citations
1,607 downloads
2,078 views

Tyrosinase is a well-known key enzyme in melanin biosynthesis and its inhibitors have become increasingly important because of their potential use as hypopigmenting agents. In the present study, the anti-melanogenic effect of aqueous and ethanolic extracts from...

["Biochemistry","Plant Science","Dermatology","Drugs and Devices"]
doi:10.7717/peerj.1305
9 citations
706 downloads
1,530 views

Mesoporous silicon has become a material of high interest for drug delivery due to its outstanding internal surface area and inherent biodegradability. We have previously reported the preparation of mesoporous silicon microparticles (MS-MPs) synthesized by an advantageous...

["Bioengineering","Drugs and Devices"]
doi:10.7717/peerj.1277
9 citations
850 downloads
1,924 views

The distortion of biomedical signals by powerline noise from recording biomedical devices has the potential to reduce the quality and convolute the interpretations of the data. Usually, powerline noise in biomedical recordings are extinguished via band-stop filters....

["Bioengineering","Computational Biology","Cardiology","Drugs and Devices","Neurology"]
doi:10.7717/peerj.1086
3 citations
488 downloads
1,071 views

Inducing cell death by heating targeted particles shows promise in cancer treatment. Here, we aim to demonstrate the feasibility of extending the use of this technique to treat and remove vascular deposits and thrombosis. We used induction heating of macrophages,...

["Bioengineering","Biophysics","Drugs and Devices","Translational Medicine"]
doi:10.7717/peerj.929
6 citations
314 downloads
1,402 views

Anecdotal accounts of tiludronate administration via intravenous regional limb perfusion (IVRLP) exist despite a lack of information regarding safety for synovial structures in the perfused area. The objective of this study was to determine whether tiludronate...

["Veterinary Medicine","Drugs and Devices","Orthopedics"]
doi:10.7717/peerj.889
1 citation
1,057 downloads
1,702 views

Objectives. We wished to determine test re-test reliability and construct validity of the star-track test of manual dexterity.Design. Test re-test reliability was examined in a controlled study. Construct validity was tested in a blinded randomized crossover study.Setting....

["Drugs and Devices","Kinesiology","Surgery and Surgical Specialties","Statistics"]
doi:10.7717/peerj.917
9 citations
383 downloads
1,566 views

Aim. Poor sleep quality due to pain has been reported among opioid-dependent male patients on methadone maintenance therapy (MMT) but objective pain data are lacking. This study aimed to investigate the rate of pain-sensitivity using cold pressor test (CPT) and...

["Anesthesiology and Pain Management","Drugs and Devices","Internal Medicine","Nursing","Pharmacology"]
doi:10.7717/peerj.839
3 citations
691 downloads
2,617 views

Reproducibility of biological data is a significant problem in research today. One potential contributor to this, which has received little attention, is the over complication of enzyme kinetic inhibition models. The over complication of inhibitory models stems...

["Biochemistry","Mathematical Biology","Neuroscience","Drugs and Devices","Pharmacology"]
doi:10.7717/peerj.649
5 citations
372 downloads
1,944 views

To determine effects of intraarticularly administered tiludronate on articular cartilage in vivo, eight healthy horses were injected once with tiludronate (low dose tiludronate [LDT] 0.017 mg, n = 4; high dose tiludronate [HDT] 50 mg, n = 4) into one middle carpal...

["Veterinary Medicine","Drugs and Devices","Rheumatology"]
doi:10.7717/peerj.534

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