Peer-reviewed Articles - Medicine

5 citations
521 downloads
2,039 views

Background: Spontaneous Reporting Systems (SRSs) are passive systems composed of reports of suspected Adverse Drug Events (ADEs), and are used for Pharmacovigilance (PhV), namely, drug safety surveillance. Exploration of analytical methodologies to enhance SRS-based...

["Drugs and Devices","Epidemiology","Pharmacology","Statistics"]
doi:10.7717/peerj.1753
13 citations
713 downloads
2,897 views

Background. Pharmacogenomic testing has the potential to improve the safety and efficacy of pharmacotherapy, but clinical application of pharmacogenetic knowledge has remained uncommon. Clinical Decision Support (CDS) systems could help overcome some of the barriers...

["Clinical Trials","Drugs and Devices","Health Policy","Human-Computer Interaction","Science Policy"]
doi:10.7717/peerj.1671
6 citations
590 downloads
2,939 views

Current research and development approaches to drug discovery have become less fruitful and more costly. One alternative paradigm is that of drug repositioning. Many marketed examples of repositioned drugs have been identified through serendipitous or rational...

["Bioinformatics","Computational Biology","Computational Science","Drugs and Devices","Pharmacology"]
doi:10.7717/peerj.1558
15 citations
1,395 downloads
3,596 views

Cell communication is central to the integration of cell function required for the development and homeostasis of multicellular animals. Proteins are an important currency of cell communication, acting locally (auto-, juxta-, or paracrine) or systemically (endocrine)....

["Biochemistry","Drugs and Devices","Surgery and Surgical Specialties","Translational Medicine"]
doi:10.7717/peerj.1535
6 citations
519 downloads
2,023 views

Substantial evidence has shown that most exogenous substances are metabolized by multiple cytochrome P450 (P450) enzymes instead of by merely one P450 isoform. Thus, multi-P450 inhibition leads to greater drug-drug interaction risk than specific P450 inhibition....

["Computational Biology","Drugs and Devices","Pharmacology"]
doi:10.7717/peerj.1524
10 citations
1,045 downloads
1,931 views

Current ovarian cancer treatment involves chemotherapy that has serious limitations, such as rapid clearance, unfavorable biodistribution and severe side effects. To overcome these limitations, drug delivery systems (DDS) have been developed to encapsulate chemotherapeutics...

["Drugs and Devices","Gynecology and Obstetrics","Oncology"]
doi:10.7717/peerj.1489
9 citations
457 downloads
1,572 views

The most described techniques used to detect diabetic retinopathy and diabetic macular edema have to be interpreted correctly, such that a person not specialized in ophthalmology, as is usually the case of a primary care physician, may experience difficulties with...

["Diabetes and Endocrinology","Drugs and Devices","Epidemiology","Human-Computer Interaction","Ophthalmology"]
doi:10.7717/peerj.1404
1 citation
424 downloads
1,663 views

Context. During the late 1990s, insecticide resistance had rendered a number of treatment products ineffective; some companies saw this as an opportunity to develop alternative types of treatment. We investigated the possibility that a surfactant-based lotion containing...

["Clinical Trials","Dermatology","Drugs and Devices","Nursing","Public Health"]
doi:10.7717/peerj.1368
4 citations
420 downloads
1,886 views

Hepatic stellate cells (HSCs) activation is essential to the pathogenesis of liver fibrosis. Exploring drugs targeting HSC activation is a promising anti-fibrotic strategy. In the present study, we found suberoylanilide hydroxamic acid (SAHA), a histone deacetylase...

["Cell Biology","Molecular Biology","Drugs and Devices","Gastroenterology and Hepatology"]
doi:10.7717/peerj.1362
8 citations
447 downloads
2,502 views

Background. When 12-to-21-year-olds start using prescription pain relievers extra-medically, some of them transition into opioid dependence within 12 months after such use. Our main aim for this epidemiological research on 12-to-21-year-olds in the United States...

["Drugs and Devices","Epidemiology","Public Health"]
doi:10.7717/peerj.1340
11 citations
1,688 downloads
2,204 views

Tyrosinase is a well-known key enzyme in melanin biosynthesis and its inhibitors have become increasingly important because of their potential use as hypopigmenting agents. In the present study, the anti-melanogenic effect of aqueous and ethanolic extracts from...

["Biochemistry","Plant Science","Dermatology","Drugs and Devices"]
doi:10.7717/peerj.1305
9 citations
728 downloads
1,572 views

Mesoporous silicon has become a material of high interest for drug delivery due to its outstanding internal surface area and inherent biodegradability. We have previously reported the preparation of mesoporous silicon microparticles (MS-MPs) synthesized by an advantageous...

["Bioengineering","Drugs and Devices"]
doi:10.7717/peerj.1277
9 citations
876 downloads
2,003 views

The distortion of biomedical signals by powerline noise from recording biomedical devices has the potential to reduce the quality and convolute the interpretations of the data. Usually, powerline noise in biomedical recordings are extinguished via band-stop filters....

["Bioengineering","Computational Biology","Cardiology","Drugs and Devices","Neurology"]
doi:10.7717/peerj.1086
3 citations
494 downloads
1,104 views

Inducing cell death by heating targeted particles shows promise in cancer treatment. Here, we aim to demonstrate the feasibility of extending the use of this technique to treat and remove vascular deposits and thrombosis. We used induction heating of macrophages,...

["Bioengineering","Biophysics","Drugs and Devices","Translational Medicine"]
doi:10.7717/peerj.929
7 citations
328 downloads
1,458 views

Anecdotal accounts of tiludronate administration via intravenous regional limb perfusion (IVRLP) exist despite a lack of information regarding safety for synovial structures in the perfused area. The objective of this study was to determine whether tiludronate...

["Veterinary Medicine","Drugs and Devices","Orthopedics"]
doi:10.7717/peerj.889

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