Peer-reviewed Articles - Medicine

44 downloads
267 views

Background Multimorbidity presents an increasingly common problem in older population, and is tightly related to polypharmacy, i.e., concurrent use of multiple medications by one individual. Detecting polypharmacy from drug prescription records is not only related...

["Drugs and Devices","Public Health","Statistics","Computational Science"]
doi:10.7717/peerj.5765
36 downloads
196 views

Background Prescription pain reliever (PPR) overdoses differentially affect ‘American Indian/Alaskan Natives’ in the United States (US). Here, studying onset of extra-medical PPR use in 12-24-year-olds, we examine subgroup variations in rates of starting to use...

["Drugs and Devices","Epidemiology","Public Health"]
doi:10.7717/peerj.5713
69 downloads
268 views

Background Acetylsalicylic acid was renamed aspirin in 1899, and it has been widely used for its multiple biological actions. Because of the diversity of the cellular processes and diseases that aspirin reportedly affects and benefits, uncertainty remains regarding...

["Bioinformatics","Drugs and Devices","Oncology"]
doi:10.7717/peerj.5667
34 downloads
193 views

Some plants popularly employed for the treatment of peptic ulcers have proved to be attractive sources of new drugs. Despite extensive research, the pharmacological and toxicological potentials of these plants are not fully understood. In this context, the aim...

["Plant Science","Drugs and Devices","Gastroenterology and Hepatology"]
doi:10.7717/peerj.5375
76 downloads
303 views

Background Intra-abdominal adhesions develop after nearly every abdominal surgery, commonly causing female infertility, chronic pelvic pain, and small bowel obstruction. Pentoxifylline (PTX) is a methylxanthine compound with immunomodulatory and antifibrotic properties....

["Drugs and Devices","Gastroenterology and Hepatology","Surgery and Surgical Specialties"]
doi:10.7717/peerj.5434
105 downloads
287 views

Background Nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently used in clinical practice, which can have adverse effects on the osteoblast. The objective of this study was to determine the effect of NSAIDs on the osteoblast by analyzing the gene expression...

["Drugs and Devices","Pharmacology"]
doi:10.7717/peerj.5415
1 citation
165 downloads
766 views

The present study comprises the synthesis of a new series of sulfonamides derived from 4-methoxyphenethylamine (1). The synthesis was initiated by the reaction of 1 with 4-methylbenzenesulfonyl chloride (2) in aqueous sodium carbonate solution at pH 9 to yield...

["Bioinformatics","Neuroscience","Cognitive Disorders","Drugs and Devices"]
doi:10.7717/peerj.4962
84 downloads
517 views

Thymidylate synthase (TS, E.C. 2.1.1.45) is a crucial enzyme for de novo deoxythymidine monophosphate (dTMP) biosynthesis. The gene for this enzyme is thyA, which encodes the folate-dependent TS that converts deoxyuridine monophosphate group (dUMP) into (dTMP)...

["Aquaculture, Fisheries and Fish Science","Biochemistry","Marine Biology","Microbiology","Drugs and Devices"]
doi:10.7717/peerj.5023
113 downloads
537 views

Candidemia and other forms of invasive fungal infections caused by Candida glabrata and to a lesser extent Saccharomyces cerevisiae are a serious health problem, especially if their steadily rising resistance to the limited range of antifungal drugs is taken into...

["Microbiology","Drugs and Devices","Infectious Diseases","Public Health"]
doi:10.7717/peerj.4999
91 downloads
550 views

Background We sought to determine the effects of unilateral lower-limb external pneumatic compression (EPC) on bilateral lower-limb vascular reactivity and skin blood flow. Methods Thirty-two participants completed this two-aim study. In AIM1 (n = 18, age: 25.5 ± 4.7...

["Anatomy and Physiology","Drugs and Devices","Kinesiology"]
doi:10.7717/peerj.4878
2 citations
135 downloads
720 views

Many infectious diseases disproportionately affect people in the developing world. Cryptococcal meningitis is one of the most common mycoses in HIV-AIDS patients, with the highest burden of disease in sub-Saharan Africa. Current best treatment regimens still result...

["Microbiology","Mycology","Drugs and Devices","Infectious Diseases"]
doi:10.7717/peerj.4761
1 citation
143 downloads
648 views

Background Beyond its traditional uses in the Balkan area, Sideritis scardica (known as Greek mountain tea, Lamiaceae) is currently extensively investigated for its pharmacological activity in the central nervous system. Antidepressant, psychostimulating, cognition-enhancing...

["Cognitive Disorders","Drugs and Devices","Pharmacology"]
doi:10.7717/peerj.4683
339 downloads
950 views

Background Polyhexamethylene biguanide (PHMB) eye drops are a frequently used medication to treat Acanthamoeba keratitis. In the absence of marketed PHMB eye drops, pharmacy-compounding units are needed to prepare this much needed treatment, but the lack of validated...

["Drugs and Devices","Ophthalmology"]
doi:10.7717/peerj.4549
569 downloads
2,732 views

Background Flexible pes planus (flat feet) in children is a common reason parents and caregivers seek health professionals consult and a frequent reason podiatrists prescribe foot orthoses. Yet no universal agreement exists on the diagnosis of this condition, or...

["Drugs and Devices","Kinesiology","Pediatrics"]
doi:10.7717/peerj.4667
282 downloads
803 views

Background Several field studies have used fuel-cell breathalysers (FCB) to investigate the prevalence of alcohol intoxication. However, there is a lack of evidence evaluating the psychometric properties of these breathalysers outside of the forensic disciplines....

["Drugs and Devices","Public Health"]
doi:10.7717/peerj.4418

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