Peer-reviewed Articles - Medicine

54 downloads
141 views

Background Diabetic kidney disease is the most common cause of chronic kidney disease (CKD). An early event in diabetic kidney disease is alteration of the glomerular basement membrane and the mesangial expansion. Matrix metalloproteinases (MMP) are a family of...

["Biochemistry","Diabetes and Endocrinology","Urology"]
doi:10.7717/peerj.6067
74 downloads
323 views

Aim Anaplastic thyroid carcinoma (ATC) is the most lethal thyroid malignancy. Identification of novel drug targets is urgently needed. Materials & Methods We re-analyzed several GEO datasets by systematic retrieval and data merging. Differentially expressed genes...

["Genetics","Diabetes and Endocrinology","Oncology"]
doi:10.7717/peerj.5822
1 citation
60 downloads
414 views

Chemerin is an adipocyte derived signalling molecule (adipokine) that serves as a ligand activator of Chemokine-like receptor 1(CMKLR1). Chemerin/CMKLR1 signalling is well established to regulate fundamental processes in metabolism and inflammation. The composition...

["Bioinformatics","Genomics","Diabetes and Endocrinology","Metabolic Sciences"]
doi:10.7717/peerj.5494
146 downloads
625 views

Sarcopenia is an age-related disease characterized by the loss of muscle mass and muscle function. A proper understanding of its pathogenesis and mechanisms may lead to new strategies for diagnosis and treatment of the disease. This study aims to discover the underlying...

["Bioinformatics","Diabetes and Endocrinology","Geriatrics","Medical Genetics"]
doi:10.7717/peerj.5239
94 downloads
408 views

Background Adult rat epididymal adipocytes are able to convert large amounts of glucose to lactate and glycerol. However, fatty acid efflux is much lower than that expected from glycerol levels if they were the product of lipolysis. Use of glucose for lipogenesis...

["Biochemistry","Diabetes and Endocrinology","Metabolic Sciences"]
doi:10.7717/peerj.5440
119 downloads
484 views

Background Differently expressed circular RNAs (circRNAs) have been reported to play a considerable role in tumor behavior; however, the expression profile and biological function of circRNAs in papillary thyroid carcinoma (PTC) remains unknown. Thus, the study...

["Genetics","Diabetes and Endocrinology","Oncology"]
doi:10.7717/peerj.5363
228 downloads
732 views

Background Obesity-induced glucose metabolism disorder is associated with chronic, low-grade, systemic inflammation and is considered a risk factor for diabetes and metabolic syndrome. Resveratrol (RES), a natural anti-inflammatory compound, is observed to improve...

["Diabetes and Endocrinology","Immunology","Nutrition","Metabolic Sciences"]
doi:10.7717/peerj.5173
123 downloads
573 views

Background The vermiform appendix serves as a “safe house” for maintaining normal gut bacteria and appendectomy may impair the intestinal microbiota. Appendectomy is expected to profoundly alter the immune system and modulate the pathogenic inflammatory immune...

["Microbiology","Diabetes and Endocrinology","Internal Medicine","Nephrology"]
doi:10.7717/peerj.5019
236 downloads
1,245 views

Background Ceratonia siliqua pods (carob) have been nominated to control the high blood glucose of diabetics. In Yemen, however, its antihyperglycemic activity has not been yet assessed. Thus, this study evaluated the in vitro inhibitory effect of the methanolic...

["Diabetes and Endocrinology","Pharmacology"]
doi:10.7717/peerj.4788
1 citation
108 downloads
501 views

Background Concomitant drug administration is a general phenomenon in patients with chronic diseases such as diabetes mellitus. Among the currently available oral antidiabetic drugs, gliclazide is a commonly prescribed drug considering its multiple benefits in...

["Diabetes and Endocrinology","Pharmacology"]
doi:10.7717/peerj.4798
150 downloads
670 views

Background Type 2 diabetes is characterized by insulin resistance accompanied by defective insulin secretion. Transgenic mouse models play an important role in medical research. However, single transgenic mouse models may not mimic the complex phenotypes of most...

["Agricultural Science","Biotechnology","Diabetes and Endocrinology","Histology","Medical Genetics"]
doi:10.7717/peerj.4542
1 citation
218 downloads
937 views

Background Cardiovascular disease is a major cause of mortality and morbidity in people with type 2 diabetes mellitus (T2DM). Studies have consistently identified dyslipidemia as an important risk factor for the development of macrovascular disease. The landmark...

["Diabetes and Endocrinology","Metabolic Sciences"]
doi:10.7717/peerj.4578
183 downloads
702 views

Background Chronic kidney disease (CKD) is characterised by long-term kidney damage and renal function decline. Diabetic CKD is the principal subtype of kidney disease in Malaysia and is associated with oxidative stress which plays an important role in development...

["Diabetes and Endocrinology","Nephrology"]
doi:10.7717/peerj.4421
139 downloads
540 views

Background Renal biopsies performed in diabetic patients are increasing and becoming more complex. Comprehensive data on modern spectrum of biopsy-proven renal disease in Chinese diabetic patients are lacking. Methods In a nationwide renal biopsy survey including...

["Diabetes and Endocrinology","Epidemiology","Nephrology","Pathology"]
doi:10.7717/peerj.4522
200 downloads
757 views

Background Serum uric acid (UA) has been reported as a risk factor for type 2 diabetes mellitus (T2DM). However, whether serum UA is associated with insulin resistance and insulin secretion, and the effect of gender on it in the case of the existed association,...

["Diabetes and Endocrinology","Epidemiology"]
doi:10.7717/peerj.4515

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