Peer-reviewed Articles - Medicine

39 downloads
234 views

Background The vermiform appendix serves as a “safe house” for maintaining normal gut bacteria and appendectomy may impair the intestinal microbiota. Appendectomy is expected to profoundly alter the immune system and modulate the pathogenic inflammatory immune...

["Microbiology","Diabetes and Endocrinology","Internal Medicine","Nephrology"]
doi:10.7717/peerj.5019
70 downloads
520 views

Background Ceratonia siliqua pods (carob) have been nominated to control the high blood glucose of diabetics. In Yemen, however, its antihyperglycemic activity has not been yet assessed. Thus, this study evaluated the in vitro inhibitory effect of the methanolic...

["Diabetes and Endocrinology","Pharmacology"]
doi:10.7717/peerj.4788
49 downloads
221 views

Background Concomitant drug administration is a general phenomenon in patients with chronic diseases such as diabetes mellitus. Among the currently available oral antidiabetic drugs, gliclazide is a commonly prescribed drug considering its multiple benefits in...

["Diabetes and Endocrinology","Pharmacology"]
doi:10.7717/peerj.4798
66 downloads
359 views

Background Type 2 diabetes is characterized by insulin resistance accompanied by defective insulin secretion. Transgenic mouse models play an important role in medical research. However, single transgenic mouse models may not mimic the complex phenotypes of most...

["Agricultural Science","Biotechnology","Diabetes and Endocrinology","Histology","Medical Genetics"]
doi:10.7717/peerj.4542
165 downloads
645 views

Background Cardiovascular disease is a major cause of mortality and morbidity in people with type 2 diabetes mellitus (T2DM). Studies have consistently identified dyslipidemia as an important risk factor for the development of macrovascular disease. The landmark...

["Diabetes and Endocrinology","Metabolic Sciences"]
doi:10.7717/peerj.4578
75 downloads
438 views

Background Chronic kidney disease (CKD) is characterised by long-term kidney damage and renal function decline. Diabetic CKD is the principal subtype of kidney disease in Malaysia and is associated with oxidative stress which plays an important role in development...

["Diabetes and Endocrinology","Nephrology"]
doi:10.7717/peerj.4421
74 downloads
304 views

Background Renal biopsies performed in diabetic patients are increasing and becoming more complex. Comprehensive data on modern spectrum of biopsy-proven renal disease in Chinese diabetic patients are lacking. Methods In a nationwide renal biopsy survey including...

["Diabetes and Endocrinology","Epidemiology","Nephrology","Pathology"]
doi:10.7717/peerj.4522
99 downloads
463 views

Background Serum uric acid (UA) has been reported as a risk factor for type 2 diabetes mellitus (T2DM). However, whether serum UA is associated with insulin resistance and insulin secretion, and the effect of gender on it in the case of the existed association,...

["Diabetes and Endocrinology","Epidemiology"]
doi:10.7717/peerj.4515
138 downloads
624 views

Background C1q TNF related protein 3 (CTRP3) is a relatively novel hormonal factor primarily derived from adipose tissue and has anti-diabetic properties. To determine if CTRP3 could play a role in early childhood development, the purpose of this study was to establish...

["Diabetes and Endocrinology","Epidemiology","Pediatrics","Women\u2019s Health"]
doi:10.7717/peerj.4472
381 downloads
1,050 views

Background & Aims Accumulating research has addressed the linkage between the changes to gut microbiota structure and type 2 diabetes (T2D). Inulin is one type of soluble dietary fiber that can alleviate T2D. As a prebiotic, inulin cannot be digested by humans,...

["Diabetes and Endocrinology"]
doi:10.7717/peerj.4446
86 downloads
379 views

Obesity and sleep fragmentation (SF) are often co-occurring pro-inflammatory conditions in patients with obstructive sleep apnea. Leptin is a peptide hormone produced by adipocytes that has anorexigenic effects upon appetite while regulating immunity. The role...

["Diabetes and Endocrinology","Immunology","Neurology"]
doi:10.7717/peerj.4423
94 downloads
494 views

Background Hypoglycemia occurs in an appreciable number of individuals with type 2 diabetes mellitus (T2DM) who are receiving glycemic therapy. Iatrogenic hypoglycemia induces not only complications but also a substantial medical expense. Intervention for relevant...

["Diabetes and Endocrinology","Metabolic Sciences"]
doi:10.7717/peerj.4348
121 downloads
579 views

Background Equine metabolic syndrome (EMS) is associated with insulin dysregulation, which often manifests as post-prandial hyperinsulinemia. Circulating concentrations of the incretin hormone, glucagon-like peptide-1 (GLP-1) correlate with an increased insulin...

["Veterinary Medicine","Diabetes and Endocrinology","Gastroenterology and Hepatology"]
doi:10.7717/peerj.4316
2 citations
225 downloads
990 views

Background Salvia officinalis (sage) is a native plant to the Mediterranean region and has been used for a long time in traditional medicine for various diseases. We investigated possible anti-diabetic, anti-inflammatory and anti-obesity effects of sage methanol...

["Diabetes and Endocrinology","Nutrition","Translational Medicine"]
doi:10.7717/peerj.4166
171 downloads
542 views

Background Autoimmune thyroid disease (AITD), which is characterized by an increased presence of thyroid autoantibodies (TAbs), such as antibodies against thyroid peroxidase (TPOAbs) and antibodies against thyroglobulin (TgAbs), has been reported to be associated...

["Diabetes and Endocrinology","Immunology","Rheumatology"]
doi:10.7717/peerj.4216

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