Peer-reviewed Articles - Medicine

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Background Medical decision-making is difficult when information is limited due to its rareness. For example, there are two treatment options for patients affected by a rare disease with high lethality. The information about both treatment effects is unavailable...

["Bioinformatics","Clinical Trials","Public Health","Ethical Issues","Statistics"]
doi:10.7717/peerj.5677
259 downloads
8,056 views

Background Blinding is critical to clinical trials because it allows for separation of specific intervention effects from bias, by equalising all factors between groups except for the proposed mechanism of action. Absent or inadequate blinding in clinical trials...

["Anesthesiology and Pain Management","Clinical Trials","Evidence Based Medicine"]
doi:10.7717/peerj.5318
73 downloads
506 views

Caused by viral infection, postherpetic neuralgia (PHN) is the most common chronic neuropathic pain. Various treatment modalities such as early use of nerve block therapy (NBT) and pulsed radiofrequency (PRF) have been studied in reducing pain, however, no consistent...

["Clinical Trials"]
doi:10.7717/peerj.4852
176 downloads
496 views

Objectives To evaluate the outcomes of patients with rheumatoid arthritis (RA) of the knee who underwent five portal arthroscopic synovectomy, with or without post-operative negative pressure drainage (NPD). Material and Methods A prospective clinical trial was...

["Clinical Trials","Immunology","Orthopedics","Rheumatology"]
doi:10.7717/peerj.4727
1 citation
169 downloads
1,004 views

Objective A subgroup of parents of children who have been treated for childhood cancer report high levels of psychological distress. To date there is no empirically supported psychological treatment targeting cancer-related psychological distress in this population....

["Clinical Trials","Oncology","Pediatrics","Psychiatry and Psychology"]
doi:10.7717/peerj.4570
1 citation
229 downloads
717 views

Acute respiratory distress syndrome (ARDS) is a highly heterogeneous syndrome that can exhibit significant differences in the underlying causes, leading to different responses to treatment. It is required to identify subtypes of ARDS to guideline clinical treatment...

["Clinical Trials","Emergency and Critical Care","Respiratory Medicine"]
doi:10.7717/peerj.4592
135 downloads
1,113 views

Background Advanced treatment of oral cancer increases survival rates; however, it also increases the risk of developing shoulder dysfunction, dysphagia, oral dysfunction, donor site morbidity and psychological issues. This single-arm preliminary pilot study aims...

["Clinical Trials","Evidence Based Medicine","Oncology"]
doi:10.7717/peerj.4419
241 downloads
825 views

Background Glycine air polishing has been proved to be safe, comfortable and time-saving. Whether it could substitute ultrasonic scaling to remove dental plaque biofilm during periodontal maintenance remains unclear. The purposes of this study were to evaluate...

["Microbiology","Clinical Trials","Dentistry","Drugs and Devices","Evidence Based Medicine"]
doi:10.7717/peerj.4371
195 downloads
895 views

Background Although it is broadly accepted that clinicians should endeavour to reassure patients with low back pain, to do so can present a significant clinical challenge. Guidance for how to provide effective reassurance is scarce and there may be a need to counter...

["Clinical Trials","Orthopedics"]
doi:10.7717/peerj.4301
235 downloads
964 views

Background Force platform training with functional electric stimulation aimed at improving balance may be effective in fall prevention for older adults. Aim of the study is to evaluate the effects of the visual-feedback-based force platform balance training with...

["Clinical Trials","Geriatrics"]
doi:10.7717/peerj.4244
1 citation
143 downloads
1,014 views

A recurrent question within oncology drug development is predicting phase III outcome for a new treatment using early clinical data. One approach to tackle this problem has been to derive metrics from mathematical models that describe tumour size dynamics termed...

["Mathematical Biology","Clinical Trials","Oncology","Pharmacology","Statistics"]
doi:10.7717/peerj.4111
1 citation
248 downloads
1,173 views

Background As the world’s second-largest economy, China has launched health reforms for the second time and invested significant funding in medical informatics (MI) since 2010; however, few studies have been conducted on the outcomes of this ambitious cause. Objective...

["Bioinformatics","Clinical Trials","Science and Medical Education"]
doi:10.7717/peerj.4082
694 downloads
3,295 views

Objectives Compare the immediate effects of a Neurodynamic Mobilization (NM) treatment or foam roller (FR) treatment after DOMS. Design Double blind randomised clinical trial. Setting The participants performed 100 drop jumps (5 sets of 20 repetitions, separated...

["Clinical Trials","Evidence Based Medicine","Geriatrics","Nursing","Rheumatology"]
doi:10.7717/peerj.3908
2 citations
224 downloads
919 views

Objective The present study aimed to assess the effects of exercise with dietary restriction on cardiac autonomic activity, arterial stiffness, and cardiovascular biomarkers in obese individuals. Methods Seventeen obese adults completed an 8-week exercise and dietary...

["Developmental Biology","Neuroscience","Cardiology","Clinical Trials"]
doi:10.7717/peerj.3900
1 citation
166 downloads
910 views

Background Providing mobility skills training to manual wheelchair (MWC) users can have a positive impact on community participation, confidence and quality of life. Often such training is restricted or not provided at all because of the expense of, and limited...

["Clinical Trials","Geriatrics","Kinesiology","Public Health"]
doi:10.7717/peerj.3879

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