Peer-reviewed Articles - Medicine

Background Only few aerobic exercise intervention trials specifically targeting cognitive functioning have been performed in multiple sclerosis. Objective and Methods This randomized controlled trial with 34 patients in the intervention group (IG) (mean: 38.2 years...

["Clinical Trials","Immunology","Neurology","Psychiatry and Psychology"]
doi:10.7717/peerj.6037
149 downloads
622 views

Background Osteoarthritis and spinal pain are common and burdensome conditions; however, the majority of patients with these conditions do not receive care that is consistent with clinical practice guidelines. Telehealth models of care have the potential to improve...

["Clinical Trials","Rheumatology"]
doi:10.7717/peerj.5846
58 downloads
337 views

Background The present study builds on previous research which explored the relationship between mentalizing and eating disorders (ED) in a subgroup of patients with comorbid self-harm (SH). Whereas previous literature had linked this comorbidity to impulse-control...

["Clinical Trials","Cognitive Disorders","Evidence Based Medicine","Nutrition","Psychiatry and Psychology"]
doi:10.7717/peerj.5756
1 citation
156 downloads
1,568 views

Introduction Cigarette smoking by surgical patients is associated with increased complications. E-cigarettes have emerged as a potential smoking cessation tool. We sought to determine the feasibility and acceptability of e-cigarettes, compared to nicotine patch,...

["Anesthesiology and Pain Management","Clinical Trials","Public Health","Respiratory Medicine","Surgery and Surgical Specialties"]
doi:10.7717/peerj.5609
86 downloads
924 views

Background Medical decision-making is difficult when information is limited due to its rareness. For example, there are two treatment options for patients affected by a rare disease with high lethality. The information about both treatment effects is unavailable...

["Bioinformatics","Clinical Trials","Public Health","Ethical Issues","Statistics"]
doi:10.7717/peerj.5677
325 downloads
8,477 views

Background Blinding is critical to clinical trials because it allows for separation of specific intervention effects from bias, by equalising all factors between groups except for the proposed mechanism of action. Absent or inadequate blinding in clinical trials...

["Anesthesiology and Pain Management","Clinical Trials","Evidence Based Medicine"]
doi:10.7717/peerj.5318
104 downloads
580 views

Caused by viral infection, postherpetic neuralgia (PHN) is the most common chronic neuropathic pain. Various treatment modalities such as early use of nerve block therapy (NBT) and pulsed radiofrequency (PRF) have been studied in reducing pain, however, no consistent...

["Clinical Trials"]
doi:10.7717/peerj.4852
216 downloads
551 views

Objectives To evaluate the outcomes of patients with rheumatoid arthritis (RA) of the knee who underwent five portal arthroscopic synovectomy, with or without post-operative negative pressure drainage (NPD). Material and Methods A prospective clinical trial was...

["Clinical Trials","Immunology","Orthopedics","Rheumatology"]
doi:10.7717/peerj.4727
1 citation
207 downloads
1,174 views

Objective A subgroup of parents of children who have been treated for childhood cancer report high levels of psychological distress. To date there is no empirically supported psychological treatment targeting cancer-related psychological distress in this population....

["Clinical Trials","Oncology","Pediatrics","Psychiatry and Psychology"]
doi:10.7717/peerj.4570
1 citation
273 downloads
806 views

Acute respiratory distress syndrome (ARDS) is a highly heterogeneous syndrome that can exhibit significant differences in the underlying causes, leading to different responses to treatment. It is required to identify subtypes of ARDS to guideline clinical treatment...

["Clinical Trials","Emergency and Critical Care","Respiratory Medicine"]
doi:10.7717/peerj.4592
1 citation
168 downloads
1,195 views

Background Advanced treatment of oral cancer increases survival rates; however, it also increases the risk of developing shoulder dysfunction, dysphagia, oral dysfunction, donor site morbidity and psychological issues. This single-arm preliminary pilot study aims...

["Clinical Trials","Evidence Based Medicine","Oncology"]
doi:10.7717/peerj.4419
298 downloads
932 views

Background Glycine air polishing has been proved to be safe, comfortable and time-saving. Whether it could substitute ultrasonic scaling to remove dental plaque biofilm during periodontal maintenance remains unclear. The purposes of this study were to evaluate...

["Microbiology","Clinical Trials","Dentistry","Drugs and Devices","Evidence Based Medicine"]
doi:10.7717/peerj.4371
226 downloads
1,039 views

Background Although it is broadly accepted that clinicians should endeavour to reassure patients with low back pain, to do so can present a significant clinical challenge. Guidance for how to provide effective reassurance is scarce and there may be a need to counter...

["Clinical Trials","Orthopedics"]
doi:10.7717/peerj.4301
265 downloads
1,075 views

Background Force platform training with functional electric stimulation aimed at improving balance may be effective in fall prevention for older adults. Aim of the study is to evaluate the effects of the visual-feedback-based force platform balance training with...

["Clinical Trials","Geriatrics"]
doi:10.7717/peerj.4244
1 citation
174 downloads
1,137 views

A recurrent question within oncology drug development is predicting phase III outcome for a new treatment using early clinical data. One approach to tackle this problem has been to derive metrics from mathematical models that describe tumour size dynamics termed...

["Mathematical Biology","Clinical Trials","Oncology","Pharmacology","Statistics"]
doi:10.7717/peerj.4111

Refine by manuscript type

Top subject areas - Articles

Top subject areas - People

View all subject areas