Peer-reviewed Articles - Medicine

35 downloads
516 views

Background When suffering from chronic pain, attempts to control or avoid pain often compete with other daily activities. Engaging in one activity excludes engaging in another, equally valued activity, which is referred to as “goal conflict.” As yet, the presence...

["Anesthesiology and Pain Management","Psychiatry and Psychology","Public Health","Translational Medicine"]
doi:10.7717/peerj.5272
204 downloads
7,607 views

Background Blinding is critical to clinical trials because it allows for separation of specific intervention effects from bias, by equalising all factors between groups except for the proposed mechanism of action. Absent or inadequate blinding in clinical trials...

["Anesthesiology and Pain Management","Clinical Trials","Evidence Based Medicine"]
doi:10.7717/peerj.5318
649 downloads
7,531 views

Background Experimental and clinical evidence support a link between body representations and pain. This proof-of-concept study in people with painful knee osteoarthritis (OA) aimed to determine if: (i) visuotactile illusions that manipulate perceived knee size...

["Neuroscience","Anesthesiology and Pain Management","Orthopedics","Psychiatry and Psychology","Rheumatology"]
doi:10.7717/peerj.5206
64 downloads
357 views

Background Angiotensin-converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARB) are the most commonly prescribed antihypertensive medications in higher-risk surgical patients. However, there is no clinical consensus on their use in the perioperative...

["Anesthesiology and Pain Management","Surgery and Surgical Specialties","Ethical Issues"]
doi:10.7717/peerj.5061
122 downloads
769 views

Background Obesity is a possible factor which affects severity of symptoms and disease activity in fibromyalgia syndrome (FMS). The aim of our study was to determine the association between body mass index (BMI) and pain, tender point count (TPC), disease activity,...

["Anesthesiology and Pain Management","Public Health","Rheumatology"]
doi:10.7717/peerj.4917
174 downloads
434 views

Estimating the depth of anaesthesia (DoA) in operations has always been a challenging issue due to the underlying complexity of the brain mechanisms. Electroencephalogram (EEG) signals are undoubtedly the most widely used signals for measuring DoA. In this paper,...

["Anesthesiology and Pain Management","Statistics","Computational Science"]
doi:10.7717/peerj.4817
86 downloads
502 views

Objectives Osteoarthritis (OA) and vitamin D deficiency are common health conditions in older people. Whether vitamin D concentration is associated with knee OA is controversial. In this study, we aimed to determine the association between serum concentrations...

["Anesthesiology and Pain Management","Orthopedics","Metabolic Sciences"]
doi:10.7717/peerj.4670
157 downloads
969 views

Background The spread of tumors through neural routes is common in several types of cancer in which patients suffer from a moderate-to-severe neuropathy, neural damage and a distorted quality of life. Here we aim to examine the expression profiles of transient...

["Molecular Biology","Neuroscience","Anesthesiology and Pain Management","Oncology","Pharmacology"]
doi:10.7717/peerj.4622
139 downloads
779 views

Background Patellofemoral pain (PFP) is often reported as a diffuse pain at the front of the knee during knee-loading activities. A patient’s description of pain location and distribution is commonly drawn on paper by clinicians, which is difficult to quantify,...

["Anesthesiology and Pain Management","Anatomy and Physiology","Orthopedics","Translational Medicine","Human\u2013Computer Interaction"]
doi:10.7717/peerj.4406
3 citations
112 downloads
659 views

Evaluation of depth of anaesthesia (DoA) is critical in clinical surgery. Indices derived from electroencephalogram (EEG) are currently widely used to quantify DoA. However, there are known to be inaccurate under certain conditions; therefore, experienced anaesthesiologists...

["Anesthesiology and Pain Management","Computational Science","Statistics"]
doi:10.7717/peerj.4067
167 downloads
863 views

The role of glial cells in pain modulation has recently gathered attention. The objective of this study was to determine healthy spinal microglia and astrocyte morphology and disposition in equine spinal cord dorsal horns using Iba-1 and GFAP/Cx-43 immunofluorescence...

["Anesthesiology and Pain Management","Molecular Biology","Neuroscience","Veterinary Medicine"]
doi:10.7717/peerj.3965
5 citations
153 downloads
842 views

Background Respondent fatigue, also known as survey fatigue, is a common problem in the collection of survey data. Factors that are known to influence respondent fatigue include survey length, survey topic, question complexity, and open-ended question type. There...

["Anesthesiology and Pain Management","Global Health","Human-Computer Interaction","Statistics"]
doi:10.7717/peerj.3785
1 citation
324 downloads
1,366 views

Background New-onset atrial fibrillation (AF) is the most common arrhythmia in critically ill patients. Although evidence base and expert consensus opinion for management have been summarised in several international guidelines, no specific considerations for critically...

["Anesthesiology and Pain Management","Cardiology","Emergency and Critical Care"]
doi:10.7717/peerj.3716
1 citation
89 downloads
603 views

Background Because etomidate induces prolonged adrenal suppression, even following a single bolus, its use as an infused anesthetic is limited. Our previous study indicated that a single administration of the novel etomidate analog methoxyethyletomidate hydrochloride...

["Anesthesiology and Pain Management","Animal Behavior","Neuroscience","Veterinary Medicine"]
doi:10.7717/peerj.3693
173 downloads
745 views

Background Hypoxia-inducible factor (HIF)-1 is involved in the regulation of hypoxic preconditioning in cardiomyocytes. Under hypoxic conditions, HIF-1α accumulates and is translocated to the nucleus, where it forms an active complex with HIF-1β and activates transcription...

["Anesthesiology and Pain Management","Cardiology","Cell Biology"]
doi:10.7717/peerj.3662

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