Peer-reviewed Articles - Computer sci

126 downloads
663 views

Complex diseases such as cancer are usually the result of a combination of environmental factors and one or several biological pathways consisting of sets of genes. Each biological pathway exerts its function by delivering signaling through the gene network. Theoretically,...

["Bioinformatics","Computational Biology"]
doi:10.7717/peerj.4571
243 downloads
1,437 views

Tip-dating, where fossils are included as dated terminal taxa in Bayesian dating inference, is an increasingly popular method. Data for these studies often come from morphological character matrices originally developed for non-dated, and usually parsimony, analyses....

["Computational Biology","Evolutionary Studies","Paleontology"]
doi:10.7717/peerj.4553
414 downloads
1,647 views

Background Plasmids play an important role in the dissemination of antibiotic resistance, making their detection an important task. Using whole genome sequencing (WGS), it is possible to capture both bacterial and plasmid sequence data, but short read lengths make...

["Bioinformatics","Computational Biology","Microbiology"]
doi:10.7717/peerj.4588
1 citation
289 downloads
1,014 views

Background A Rohingya refugee camp in Cox’s Bazar, Bangladesh experienced a large-scale diphtheria epidemic in 2017. The background information of previously immune fraction among refugees cannot be explicitly estimated, and thus we conducted an uncertainty analysis...

["Computational Biology","Mathematical Biology","Epidemiology","Global Health","Infectious Diseases"]
doi:10.7717/peerj.4583
110 downloads
663 views

Background Labels are a way to add some information on a text, such as functional annotations such as genes on a DNA sequences. V(D)J recombinations are DNA recombinations involving two or three short genes in lymphocytes. Sequencing this short region (500 bp or...

["Bioinformatics","Computational Biology","Algorithms and Analysis of Algorithms"]
doi:10.7717/peerj-cs.148
1 citation
186 downloads
1,193 views

Membrane-bound fatty acid desaturases perform oxygenated desaturation reactions to insert double bonds within fatty acyl chains in regioselective and stereoselective manners. The Δ9-fatty acid desaturase strictly creates the first double bond between C9 and 10...

["Biotechnology","Computational Biology","Microbiology"]
doi:10.7717/peerj.4347
1 citation
242 downloads
1,627 views

Background Real-time quantitative PCR (qPCR) is a broadly used technique in the biomedical research. Currently, few different analysis models are used to determine the quality of data and to quantify the mRNA level across the experimental conditions. Methods We...

["Bioinformatics","Cell Biology","Computational Biology","Molecular Biology"]
doi:10.7717/peerj.4473
182 downloads
1,608 views

RNA editing modifies transcripts and may alter their regulation or function. In humans, the most common modification is adenosine to inosine (A-to-I). We examined the global characteristics of RNA editing in 4,301 human tissue samples. More than 1.6 million A-to-I...

["Computational Biology","Genetics","Genomics","Cardiology","Computational Science"]
doi:10.7717/peerj.4466
319 downloads
1,120 views

African swine fever virus (ASFV) is the etiological agent of ASF, a fatal hemorrhagic fever that affects domestic pigs. There is currently no vaccine against ASFV, making it a significant threat to the pork industry. The ASFV genome sequence has been published;...

["Biochemistry","Bioinformatics","Biotechnology","Computational Biology"]
doi:10.7717/peerj.4396
161 downloads
940 views

C9orf72 is associated with frontotemporal dementia (FTD) and Amyotrophic Lateral Sclerosis (ALS), both of which are devastating neurodegenerative diseases. Findings suggest that an expanded hexanucleotide repeat in the non-coding region of the C9orf72 gene is the...

["Bioinformatics","Computational Biology","Genomics"]
doi:10.7717/peerj.4391
1 citation
280 downloads
1,490 views

Complex networks have been successfully applied to the characterization and modeling of complex systems in several distinct areas of Biological Sciences. Nevertheless, their utilization in phylogenetic analysis still needs to be widely tested, using different molecular...

["Bioinformatics","Computational Biology","Evolutionary Studies"]
doi:10.7717/peerj.4349
4 citations
120 downloads
1,014 views

We introduce LEISR (Likehood Estimation of Individual Site Rates, pronounced “laser”), a tool to infer relative evolutionary rates from protein and nucleotide data, implemented in HyPhy. LEISR is based on the popular Rate4Site (Pupko et al., 2002) approach for...

["Bioinformatics","Computational Biology","Evolutionary Studies","Genomics"]
doi:10.7717/peerj.4339
4 citations
336 downloads
1,333 views

The ubiquitous daily rhythms in mammalian physiology are guided by progression of the circadian clock. In mice, systemic disruption of the clock can promote tumor growth. In vitro, multiple oncogenes can disrupt the clock. However, due to the difficulties of studying...

["Bioinformatics","Computational Biology","Genomics","Oncology"]
doi:10.7717/peerj.4327
196 downloads
1,104 views

Plasma lipid levels are risk factors for cardiovascular disease, a leading cause of death worldwide. While many studies have been conducted on lipid genetics, they mainly focus on Europeans and thus their transferability to diverse populations is unclear. We performed...

["Computational Biology","Genetics","Genomics"]
doi:10.7717/peerj.4314
277 downloads
1,472 views

Understanding how structural and functional alterations of individual tissues impact on whole-joint function is challenging, particularly in humans where direct invasive experimentation is difficult. Finite element (FE) computational models produce quantitative...

["Bioengineering","Biotechnology","Computational Biology"]
doi:10.7717/peerj.4298

Refine by manuscript type

Top subject areas - Articles

Top subject areas - People

View all subject areas