Peer-reviewed Articles - Computer sci

8 downloads
132 views

Background Bayesian networks are directed acyclic graphical models widely used to represent the probabilistic relationships between random variables. They have been applied in various biological contexts, including gene regulatory networks and protein–protein interactions...

["Bioinformatics","Computational Biology"]
doi:10.7717/peerj.5692
14 downloads
73 views

Dramatic increases in data produced by next-generation sequencing (NGS) technologies demand data compression tools for saving storage space. However, effective and efficient data compression for genome sequencing data has remained an unresolved challenge in NGS...

["Bioinformatics","Biotechnology","Computational Science","Data Science"]
doi:10.7717/peerj.5611
28 downloads
158 views

As one of the non-selective cation channel gene families, the cyclic nucleotide-gated channel (CNGC) gene family plays a vital role in plant physiological processes that are related to signal pathways, plant development, and environmental stresses. However, genome-wide...

["Bioinformatics","Genomics","Plant Science"]
doi:10.7717/peerj.5816
29 downloads
134 views

Protein backbones occupy diverse conformations, but compact metrics to describe such conformations and transitions between them have been missing. This report re-introduces the Ramachandran number (ℛ) as a residue-level structural metric that could simply the life...

["Bioinformatics","Computational Biology","Mathematical Biology"]
doi:10.7717/peerj.5745
28 downloads
217 views

Background HIV-associated encephalitis (HIVE) is one of the common complications of HIV infection, and the pathogenesis of HIVE remains unclear, while lncRNA might be involved it. In this study, we made re-annotation on the expression profiling from the HIVE study...

["Bioinformatics","HIV"]
doi:10.7717/peerj.5721
40 downloads
249 views

Background Osteoclast differentiation in the inflamed synovium of rheumatoid arthritis (RA) affected joints leads to the formation of bone lesions. Reconstruction and analysis of protein interaction networks underlying specific disease phenotypes are essential...

["Bioinformatics","Computational Biology","Genomics","Immunology","Rheumatology"]
doi:10.7717/peerj.5743
47 downloads
229 views

Acquiring data on the occurrences of many types of difficult to identify objects are often still made by human observation, for example, in biodiversity and paleontologic research. Existing computer counting programs used to record such data have various limitations,...

["Biodiversity","Bioinformatics","Ecology","Paleontology"]
doi:10.7717/peerj.5453
47 downloads
193 views

The number of amino acids that occupy a given protein site during evolution reflects the selective constraints operating on the site. This evolutionary variability is strongly influenced by the structural properties of the site in the native structure, and it is...

["Bioinformatics","Biophysics","Computational Biology","Evolutionary Studies"]
doi:10.7717/peerj.5549
56 downloads
530 views

High-throughput phenotyping has emerged as a powerful method for studying plant biology. Large image-based datasets are generated and analyzed with automated image analysis pipelines. A major challenge associated with these analyses is variation in image quality...

["Bioinformatics","Plant Science"]
doi:10.7717/peerj.5727
44 downloads
238 views

Model-free methods are widely used for the processing of brain fMRI data collected under natural stimulations, sleep, or rest. Among them is the popular fuzzy c-mean algorithm, commonly combined with cluster validity (CV) indices to identify the ‘true’ number of...

["Bioinformatics","Computational Biology","Neuroscience"]
doi:10.7717/peerj.5416
277 downloads
2,280 views

Polymorphic phenotypes of mammalian coat coloration have been important to the study of genetics and evolution, but less is known about the inheritance and fitness consequences of individual variation in complex coat pattern traits such as spots and stripes. Giraffe...

["Bioinformatics","Evolutionary Studies","Zoology"]
doi:10.7717/peerj.5690
41 downloads
169 views

Xeno-miRNAs are microRNAs originating from exogenous species detected in host biofluids. A growing number of studies have suggested that many of these xeno-miRNAs may be involved in cross-species interactions and manipulations. To date, hundreds of xeno-miRNAs...

["Bioinformatics","Computational Biology","Genetics","Genomics","Parasitology"]
doi:10.7717/peerj.5650
53 downloads
266 views

Soil salinity is one of the major environmental stresses affecting plant growth, development, and reproduction. Salt stress also affects the accumulation of some secondary metabolites in plants. Glehnia littoralis is an endangered medicinal halophyte that grows...

["Agricultural Science","Bioinformatics","Genomics","Plant Science"]
doi:10.7717/peerj.5681
68 downloads
264 views

Background Acetylsalicylic acid was renamed aspirin in 1899, and it has been widely used for its multiple biological actions. Because of the diversity of the cellular processes and diseases that aspirin reportedly affects and benefits, uncertainty remains regarding...

["Bioinformatics","Drugs and Devices","Oncology"]
doi:10.7717/peerj.5667
58 downloads
760 views

Background Medical decision-making is difficult when information is limited due to its rareness. For example, there are two treatment options for patients affected by a rare disease with high lethality. The information about both treatment effects is unavailable...

["Bioinformatics","Clinical Trials","Public Health","Ethical Issues","Statistics"]
doi:10.7717/peerj.5677

Refine by manuscript type

Top subject areas - Articles

Top subject areas - People

View all subject areas