Peer-reviewed Articles - Biology

45 downloads
269 views

We present PromoterPredict, a dynamic multiple regression approach to predict the strength of Escherichia coli promoters binding the σ70 factor of RNA polymerase. σ70 promoters are ubiquitously used in recombinant DNA technology, but characterizing their strength...

["Bioinformatics","Computational Biology","Genomics","Synthetic Biology","Data Mining and Machine Learning"]
doi:10.7717/peerj.5862
73 downloads
270 views

Two novel peptides belonging to the dermaseptin family, namely DRS-CA-1 and DRS-DU-1, were encoded from cDNA libraries derived from the skin secretions of Phyllomedusa camba and Callimedusa (Phyllomedusa) duellmani. Both natural peptides are highly-conserved and...

["Biochemistry","Bioengineering","Molecular Biology","Synthetic Biology"]
doi:10.7717/peerj.5635
160 downloads
877 views

The maintenance of a G + C content that is higher than the mutational input to a genome provides support for the view that selection serves to increase G + C contents in bacteria. Recent experimental evidence from Escherichia coli demonstrated that selection for...

["Biotechnology","Evolutionary Studies","Genetics","Molecular Biology","Synthetic Biology"]
doi:10.7717/peerj.4286
3 citations
323 downloads
1,077 views

With the rapid advancement of regenerative medicine technologies, there is an urgent need for the development of new, cell-friendly techniques for obtaining nanofibers—the raw material for an artificial extracellular matrix production. We investigated the structure...

["Bioengineering","Biotechnology","Synthetic Biology"]
doi:10.7717/peerj.4125
350 downloads
1,265 views

Carbon nanotubes (CNTs) have a broad range of applications and are generally considered human-engineered nanomaterials. However, carbon nanostructures have been found in ice cores and oil wells, suggesting that nature may provide appropriate conditions for CNT...

["Biochemistry","Ecology","Ecosystem Science","Soil Science","Synthetic Biology"]
doi:10.7717/peerj.3658
147 downloads
1,199 views

Cleavage of mRNA molecules causes their rapid degradation, thereby playing an important role in regulation of gene expression and host genome defense from viruses and transposons in bacterial and eukaryotic cells. Current negative-readout, and repressor-based positive-readout...

["Bioengineering","Molecular Biology","Synthetic Biology"]
doi:10.7717/peerj.3602
8 citations
235 downloads
1,288 views

Snakebite envenomings represent a neglected public health issue in many parts of the rural tropical world. Animal-derived antivenoms have existed for more than a hundred years and are effective in neutralizing snake venom toxins when timely administered. However,...

["Bioinformatics","Biotechnology","Toxicology","Immunology","Synthetic Biology"]
doi:10.7717/peerj.2924
1 citation
483 downloads
1,965 views

Microbes growing in animal host environments face fluctuations that have elements of both randomness and predictability. In the mammalian gut, fluctuations in nutrient levels and other physiological parameters are structured by the host’s behavior, diet, health...

["Computational Biology","Ecology","Mathematical Biology","Microbiology","Synthetic Biology"]
doi:10.7717/peerj.2716
3 citations
366 downloads
1,403 views

Background This study examines the biophysical and preclinical pulmonary activity of synthetic lung surfactants containing novel phospholipase-resistant phosphonolipids or synthetic glycerophospholipids combined with Super Mini-B (S-MB) DATK and/or SP-Css ion-lock...

["Bioengineering","Biophysics","Respiratory Medicine","Synthetic Biology"]
doi:10.7717/peerj.2635
23 citations
3,607 downloads
4,006 views

Background There is worldwide interest in silver nanoparticles (AgNPs) synthesized by various chemical reactions for use in applications exploiting their antibacterial activity, even though these processes exhibit a broad range of toxicity in vertebrates and invertebrates...

["Biotechnology","Microbiology","Synthetic Biology"]
doi:10.7717/peerj.2589
2 citations
364 downloads
2,498 views

The F1 sub-complex of ATP synthase is a biological nanomotor that converts the free energy of ATP hydrolysis into mechanical work with an astonishing efficiency of up to 100% (Kinosita et al., 2000). To probe the principal mechanics of the machine, I re-engineered...

["Biochemistry","Bioengineering","Biophysics","Synthetic Biology"]
doi:10.7717/peerj.2286
1 citation
363 downloads
2,607 views

Aim. The nascent field of bio-geoengineering stands to benefit from synthetic biologists’ efforts to standardise, and in so doing democratise, biomolecular research methods. Roseobacter clade bacteria comprise 15–20% of oceanic bacterio-plankton communities, making...

["Bioengineering","Marine Biology","Molecular Biology","Science Policy","Synthetic Biology"]
doi:10.7717/peerj.2031
12 citations
940 downloads
2,898 views

Ralstonia eutropha H16 is a facultatively autotrophic hydrogen-oxidizing bacterium capable of producing polyhydroxybutyrate (PHB)-based bioplastics. As PHB’s physical properties may be improved by incorporation of medium-chain-length fatty acids (MCFAs), and MCFAs...

["Bioengineering","Microbiology","Synthetic Biology"]
doi:10.7717/peerj.1468
619 downloads
1,813 views

Two Component Systems and Phosphorelays (TCS/PR) are environmental signal transduction cascades in prokaryotes and, less frequently, in eukaryotes. The internal domain organization of proteins and the topology of TCS/PR cascades play an important role in shaping...

["Bioinformatics","Computational Biology","Mathematical Biology","Synthetic Biology"]
doi:10.7717/peerj.1183
6 citations
613 downloads
2,138 views

Using a carefully designed search query, we describe the field of synthetic biology in terms of leading countries, organizations and funding sources. Besides articles we also paid some attention to patents. The USA is the leading country in this field, followed...

["Science and Medical Education","Statistics","Synthetic Biology","Computational Science"]
doi:10.7717/peerj.728

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