Peer-reviewed Articles - Biology

9 downloads
73 views

The classical way of defining enzyme inhibition has obscured the distinction between inhibitory effect and the inhibitor binding constant. This article examines the relationship between the simple binding curve used to define biomolecular interactions and the standard...

["Biochemistry","Computational Biology","Mathematical Biology","Drugs and Devices","Pharmacology"]
doi:10.7717/peerj.6082
30 downloads
202 views

Background Mesenchymal stem/stromal cells (MSCs) are a promising tool for cell-based therapies in the treatment of tissue injury. The stromal cell-derived factor-1 (SDF-1)/CXC chemokine receptor 4 (CXCR4) axis plays a significant role in directing MSC homing to...

["Cell Biology","Mathematical Biology","Drugs and Devices"]
doi:10.7717/peerj.6072
37 downloads
192 views

Axonal stimulation with electric currents is an effective method for controlling neural activity. An electric field parallel to the axon is widely accepted as the predominant component in the activation of an axon. However, recent studies indicate that the transverse...

["Biophysics","Computational Biology","Mathematical Biology","Neurology"]
doi:10.7717/peerj.6020
65 downloads
343 views

Gammatones have had a long history in auditory studies, and recent theoretical work suggests they may play an important role in cochlear mechanics as well. Following this lead, the present paper takes five examples of basilar membrane impulse responses and uses...

["Biophysics","Computational Biology","Mathematical Biology","Neuroscience","Otorhinolaryngology"]
doi:10.7717/peerj.6016
53 downloads
204 views

The Bertalanffy–Pütter growth model describes mass m at age t by means of the differential equation dm/dt = p * ma − q * mb. The special case using the von Bertalanffy exponent-pair a = 2/3 and b = 1 is most common (it corresponds to the von Bertalanffy growth...

["Aquaculture, Fisheries and Fish Science","Computational Biology","Mathematical Biology","Computational Science","Natural Resource Management"]
doi:10.7717/peerj.5973
63 downloads
278 views

Protein backbones occupy diverse conformations, but compact metrics to describe such conformations and transitions between them have been missing. This report re-introduces the Ramachandran number (ℛ) as a residue-level structural metric that could simply the life...

["Bioinformatics","Computational Biology","Mathematical Biology"]
doi:10.7717/peerj.5745
70 downloads
305 views

Animal societies vary widely in the diversity of social behaviour and the distribution of reproductive shares among their group members. It has been shown that individual condition can lead to divergent social roles and that social specialisation can cause an exacerbation...

["Animal Behavior","Ecology","Evolutionary Studies","Mathematical Biology","Population Biology"]
doi:10.7717/peerj.5488
85 downloads
513 views

Ecologists often analyze relative abundances, which are an example of compositional data. However, they have made surprisingly little use of recent advances in the field of compositional data analysis. Compositions form a vector space in which addition and scalar...

["Ecology","Marine Biology","Mathematical Biology"]
doi:10.7717/peerj.5643
80 downloads
392 views

In single-cell RNA-sequencing, it is important to know the frequency at which the sequenced transcriptomes actually derive from multiple cells. A common method to estimate this multiplet frequency is to mix two different types of cells (e.g., human and mouse),...

["Bioinformatics","Computational Biology","Genomics","Mathematical Biology"]
doi:10.7717/peerj.5578
1 citation
128 downloads
537 views

Synechocystis gathered momentum in modelling studies and biotechnological applications owing to multiple factors like fast growth, ability to fix carbon dioxide into valuable products, and the relative ease of genetic manipulation. Synechocystis physiology and...

["Biochemistry","Biotechnology","Cell Biology","Mathematical Biology","Computational Science"]
doi:10.7717/peerj.5256
139 downloads
424 views

The dsDNA bacteriophage T7 was subjected to 30 cycles of lethal ultraviolet light (UV) exposure to select increased resistance to UV. The exposure effected a 0.9999 kill of the ancestral population, and survival of the ending population was nearly 50-fold improved....

["Genetics","Genomics","Mathematical Biology"]
doi:10.7717/peerj.5190
131 downloads
621 views

Rao’s quadratic diversity index is one of the most widely applied diversity indices in functional and phylogenetic ecology. The standard way of computing Rao’s quadratic diversity index for an ecological assemblage with a group of species with varying abundances...

["Biodiversity","Ecology","Mathematical Biology","Plant Science"]
doi:10.7717/peerj.5211
297 downloads
978 views

Background Site fidelity is considered as an animal’s tendency to return to a previously occupied place; this is a component of animal behaviour that allows us to understand movement patterns and aspects related to the animal’s life history. Although there are...

["Animal Behavior","Ecology","Mathematical Biology","Statistics","Population Biology"]
doi:10.7717/peerj.4782
115 downloads
734 views

Background The globally abundant coccolithophore, Emiliania huxleyi, plays an important ecological role in oceanic carbon biogeochemistry by forming a cellular covering of plate-like CaCO3 crystals (coccoliths) and fixing CO2. It is unknown how the cells arrange...

["Mathematical Biology"]
doi:10.7717/peerj.4608
1 citation
364 downloads
1,154 views

Background A Rohingya refugee camp in Cox’s Bazar, Bangladesh experienced a large-scale diphtheria epidemic in 2017. The background information of previously immune fraction among refugees cannot be explicitly estimated, and thus we conducted an uncertainty analysis...

["Computational Biology","Mathematical Biology","Epidemiology","Global Health","Infectious Diseases"]
doi:10.7717/peerj.4583

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