Peer-reviewed Articles - Biology

22 downloads
114 views

Müller glia in the zebrafish retina respond to retinal damage by re-entering the cell cycle, which generates large numbers of retinal progenitors that ultimately replace the lost neurons. In this study we compared the regenerative outcomes of adult zebrafish exposed...

["Cell Biology","Developmental Biology","Molecular Biology","Neuroscience","Ophthalmology"]
doi:10.7717/peerj.5646
21 downloads
488 views

Drosophila melanogaster larvae detect noxious thermal and mechanical stimuli in their environment using polymodal nociceptor neurons whose dendrites tile the larval body wall. Activation of these nociceptors by potentially tissue-damaging stimuli elicits a stereotyped...

["Cell Biology","Genetics","Molecular Biology","Neuroscience"]
doi:10.7717/peerj.5632
24 downloads
234 views

Plant flavonoid metabolism has served as a platform for understanding a range of fundamental biological phenomena, including providing some of the early insights into the subcellular organization of metabolism. Evidence assembled over the past three decades points...

["Biochemistry","Cell Biology","Plant Science"]
doi:10.7717/peerj.5598
23 downloads
134 views

Combination Index (CI) analysis suggested that MBIC and doxorubicin synergistically inhibited up to 97% of cell proliferation in ER+/PR+MCF-7 and triple negative MDA-MB-231 breast cancer cell lines. Moreover, treatment of the breast cancer cells with the combined...

["Cell Biology","Oncology"]
doi:10.7717/peerj.5577
44 downloads
238 views

GDF11, a member of TGF-β superfamily, has recently received widespread attention as a novel anti-ageing/rejuvenation factor to reverse age-related dysfunctions in heart and skeletal muscle, and to induce angiogenesis and neurogenesis. However, these positive effects...

["Biochemistry","Bioinformatics","Cell Biology","Neuroscience","Evidence Based Medicine"]
doi:10.7717/peerj.5524
59 downloads
514 views

Background A key event in human development is the establishment of erythropoietic progenitors in the bone marrow, which is accompanied by a fetal-to-adult switch in hemoglobin expression. Understanding of this event could lead to medical application, notably treatment...

["Bioinformatics","Cell Biology","Hematology"]
doi:10.7717/peerj.5527
42 downloads
269 views

Background Under aerobic growth conditions, mitochondria are the major producers of cellular ATP and crucial for the proper performance of organs and tissues. This applies especially to cells with high energy demand, such as the renal proximal tubule epithelium....

["Cell Biology","Molecular Biology"]
doi:10.7717/peerj.5469
28 downloads
242 views

The uses of fluorescent microscopy and fluorescent probes, such as the metabolically activated probe CellTracker™  Green CMFDA (CTG), have become common in studies of living Foraminifera. This metabolic requirement, as well as the relatively quick production of...

["Cell Biology","Ecology","Marine Biology"]
doi:10.7717/peerj.5304
1 citation
130 downloads
380 views

Circular RNA (circRNA) is an endogenous noncoding RNA with a covalently closed cyclic structure. Based on their components, circRNAs are divided into exonic circRNAs, intronic circRNAs, and exon-intron circRNAs. CircRNAs have well-conserved sequences and often...

["Biochemistry","Cell Biology"]
doi:10.7717/peerj.5503
76 downloads
518 views

The family of forkhead box (Fox) transcription factors regulates gonadogenesis and embryogenesis, but the role of foxr1 in reproduction is unknown. Evolutionary history of foxr1 in vertebrates was examined and the gene was found to exist in most vertebrates, including...

["Aquaculture, Fisheries and Fish Science","Cell Biology","Developmental Biology","Evolutionary Studies","Genetics"]
doi:10.7717/peerj.5534
145 downloads
630 views

The beneficial effects of prebiotic fibres on human health have been related to their capacities to alter the gut microbiota and modify the growth of beneficial microorganisms. It is long appreciated that bacterial metabolites affect the host’s physiology. The...

["Cell Biology","Food Science and Technology","Microbiology","Gastroenterology and Hepatology","Nutrition"]
doi:10.7717/peerj.5288
75 downloads
362 views

Background Thiazolidinediones (TZDs), also called glitazones, are five-membered carbon ring molecules commonly used for the management of insulin resistance and type 2 diabetes. Recently, many prospective studies have also documented the impact of these compounds...

["Cell Biology"]
doi:10.7717/peerj.5386
167 downloads
7,446 views

Background We sought to examine how 12 weeks of resistance exercise training (RET) affected skeletal muscle myofibrillar and sarcoplasmic protein levels along with markers of mitochondrial physiology in high versus low anabolic responders. Methods Untrained college-aged...

["Cell Biology","Kinesiology"]
doi:10.7717/peerj.5338
83 downloads
384 views

Synechocystis gathered momentum in modelling studies and biotechnological applications owing to multiple factors like fast growth, ability to fix carbon dioxide into valuable products, and the relative ease of genetic manipulation. Synechocystis physiology and...

["Biochemistry","Biotechnology","Cell Biology","Mathematical Biology","Computational Science"]
doi:10.7717/peerj.5256
105 downloads
371 views

Background Stargardt disease (SD) is characterized by the accumulation of the age-pigment lipofuscin in the retinal pigment epithelium (RPE) and subsequent neuroretinal degeneration. The disease leads to vision loss early in life. Here, we investigate age-dependent...

["Cell Biology","Neuroscience","Ophthalmology","Pathology","Histology"]
doi:10.7717/peerj.5215

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