Peer-reviewed Articles - Biology

30 downloads
202 views

Background Mesenchymal stem/stromal cells (MSCs) are a promising tool for cell-based therapies in the treatment of tissue injury. The stromal cell-derived factor-1 (SDF-1)/CXC chemokine receptor 4 (CXCR4) axis plays a significant role in directing MSC homing to...

["Cell Biology","Mathematical Biology","Drugs and Devices"]
doi:10.7717/peerj.6072
43 downloads
166 views

Background DNA repair is essential to counteract damage to DNA induced by endo- and exogenous factors, to maintain genome stability. However, challenges to the faithful discrimination between damaged and non-damaged DNA strands do exist, such as mismatched pairs...

["Biochemistry","Cell Biology","Genetics","Molecular Biology","Oncology"]
doi:10.7717/peerj.6029
40 downloads
248 views

Background In horses and ponies, insulin dysregulation leading to hyperinsulinemia may be associated with increased risk of laminitis, and prolonged infusion of insulin can induce the condition. It is unclear whether insulin may have a direct or indirect effect...

["Cell Biology","Veterinary Medicine","Metabolic Sciences"]
doi:10.7717/peerj.5945
48 downloads
204 views

Aedes albopictus is a primary vector of hundreds of pathogens. Strong environmental adaptability and extensive global distribution of Aedes albopictus make it a severe threat to human health. Autophagy is a cellular process involved in maintenance of cellular homeostasis...

["Biochemistry","Cell Biology","Entomology","Molecular Biology","Parasitology"]
doi:10.7717/peerj.5988
46 downloads
321 views

Background Prostate cancer (PC) diagnostics and treatment often present a challenging task due to cancer subtype heterogeneity and differential disease progression in patient subgroups. Hence, the critical issue is finding a reliable and sensitive diagnostic and...

["Cell Biology","Molecular Biology","Oncology"]
doi:10.7717/peerj.5970
54 downloads
288 views

Articular cartilage is an avascular tissue with limited regenerative property. Therefore, a defect or trauma in articular cartilage due to disease or accident can lead to progressive tissue deterioration. Cartilage tissue engineering, by replacing defective cartilage...

["Bioengineering","Biotechnology","Cell Biology","Developmental Biology","Translational Medicine"]
doi:10.7717/peerj.5809
69 downloads
237 views

Mitochondrial pyruvate carrier 1 (MPC1) is a component of the MPC1/MPC2 heterodimer that facilitates the transport of pyruvate into mitochondria. Pyruvate plays a central role in carbohydrate, fatty, and amino acid catabolism. The present study examined epididymal...

["Cell Biology","Developmental Biology","Molecular Biology"]
doi:10.7717/peerj.5799
118 downloads
741 views

Congenital heart disease (CHD) affects a considerable number of children and adults worldwide. This implicates not only developmental disorders, high mortality, and reduced quality of life but also, high costs for the healthcare systems. CHD refers to a variety...

["Cell Biology","Developmental Biology","Anatomy and Physiology","Cardiology","Pathology"]
doi:10.7717/peerj.5805
72 downloads
355 views

Background Senescence-related impairment of proliferation and differentiation limits the use of dental pulp cells for tissue regeneration. Deletion of sclerostin improves the dentinogenesis regeneration, while its role in dental pulp senescence is unclear. We investigated...

["Biochemistry","Cell Biology","Molecular Biology"]
doi:10.7717/peerj.5808
81 downloads
355 views

Leaves from three varieties of Ficus deltoidea, colloquially termed small- (FDS), medium- (FDM), and big-type leaf (FDB), were subjected to water extraction. The crude extracts were fractionated using water (WF) and ethyl acetate (EAF). The phenolic and flavonoid...

["Biochemistry","Cell Biology","Food Science and Technology","Plant Science","Translational Medicine"]
doi:10.7717/peerj.5694
93 downloads
357 views

Both age and intensive exercise are generally considered critical risk factors for osteoarthritis. In this work, we intend to establish zebrafish models to assess the role of these two factors on cartilage homeostasis. We designed a swimming device for zebrafish...

["Cell Biology","Veterinary Medicine","Zoology","Rheumatology"]
doi:10.7717/peerj.5739
84 downloads
375 views

Studies on the adverse health effects caused by azo dyes are insufficient and quite contradictory. This work aims to investigate the possible toxic effect of two types of widely used food additives, Sunset Yellow and Allura Red, by assessing the physiological,...

["Cell Biology","Molecular Biology","Toxicology","Public Health","Histology"]
doi:10.7717/peerj.5689
80 downloads
366 views

Proteins of the DUF866 superfamily are exclusively found in eukaryotic cells. A member of the DUF866 superfamily, C1ORF123, is a human protein found in the open reading frame 123 of chromosome 1. The physiological role of C1ORF123 is yet to be determined. The only...

["Biochemistry","Biophysics","Cell Biology","Molecular Biology"]
doi:10.7717/peerj.5377
98 downloads
373 views

Müller glia in the zebrafish retina respond to retinal damage by re-entering the cell cycle, which generates large numbers of retinal progenitors that ultimately replace the lost neurons. In this study we compared the regenerative outcomes of adult zebrafish exposed...

["Cell Biology","Developmental Biology","Molecular Biology","Neuroscience","Ophthalmology"]
doi:10.7717/peerj.5646
59 downloads
664 views

Drosophila melanogaster larvae detect noxious thermal and mechanical stimuli in their environment using polymodal nociceptor neurons whose dendrites tile the larval body wall. Activation of these nociceptors by potentially tissue-damaging stimuli elicits a stereotyped...

["Cell Biology","Genetics","Molecular Biology","Neuroscience"]
doi:10.7717/peerj.5632

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