Peer-reviewed Articles - Biology

92 downloads
202 views

Protein structure is not static; residues undergo conformational rearrangements and, in doing so, create, stabilize or break non-covalent interactions. Molecular dynamics (MD) is a technique used to simulate these movements with atomic resolution. However, given...

["Bioinformatics","Biophysics","Computational Biology"]
doi:10.7717/peerj.5998
37 downloads
192 views

Axonal stimulation with electric currents is an effective method for controlling neural activity. An electric field parallel to the axon is widely accepted as the predominant component in the activation of an axon. However, recent studies indicate that the transverse...

["Biophysics","Computational Biology","Mathematical Biology","Neurology"]
doi:10.7717/peerj.6020
65 downloads
343 views

Gammatones have had a long history in auditory studies, and recent theoretical work suggests they may play an important role in cochlear mechanics as well. Following this lead, the present paper takes five examples of basilar membrane impulse responses and uses...

["Biophysics","Computational Biology","Mathematical Biology","Neuroscience","Otorhinolaryngology"]
doi:10.7717/peerj.6016
51 downloads
231 views

Background Remote photoplethysmography (rPPG) is a promising optical method for non-contact assessment of pulse rate (PR) from video recordings. In order to implement the method in real-time applications, it is necessary for the rPPG algorithms to be capable of...

["Biophysics","Anatomy and Physiology","Computational Science"]
doi:10.7717/peerj.5859
47 downloads
231 views

Background The effects of resistance training on a muscle’s neural, architectural, and mechanical properties are well established. However, whether resistance training can positively change the coordination of multiple motor elements in the control of a well-defined...

["Biophysics","Neuroscience","Kinesiology"]
doi:10.7717/peerj.6010
151 downloads
740 views

Background A review of the literature has indicated that lower body stiffness, defined as the extent to which the lower extremity joints resists deformation upon contact with the ground, may be a useful measure for assessing Achilles injury risk in triathletes....

["Biophysics","Kinesiology"]
doi:10.7717/peerj.5845
255 downloads
3,276 views

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), two late onset neurodegenerative diseases, have been shown to share overlapping cellular pathologies and genetic origins. Studies suggest that a hexanucleotide repeat expansion in the first...

["Biochemistry","Biophysics","Molecular Biology"]
doi:10.7717/peerj.5815
64 downloads
255 views

The number of amino acids that occupy a given protein site during evolution reflects the selective constraints operating on the site. This evolutionary variability is strongly influenced by the structural properties of the site in the native structure, and it is...

["Bioinformatics","Biophysics","Computational Biology","Evolutionary Studies"]
doi:10.7717/peerj.5549
80 downloads
366 views

Proteins of the DUF866 superfamily are exclusively found in eukaryotic cells. A member of the DUF866 superfamily, C1ORF123, is a human protein found in the open reading frame 123 of chromosome 1. The physiological role of C1ORF123 is yet to be determined. The only...

["Biochemistry","Biophysics","Cell Biology","Molecular Biology"]
doi:10.7717/peerj.5377
87 downloads
707 views

Natural aquatic environments such as oceans, lakes, and rivers are home to a tremendous diversity of microorganisms. Some may cross the air-water interface within droplets and become airborne, with the potential to impact the Earth’s radiation budget, precipitation...

["Biophysics","Microbiology","Freshwater Biology","Ecohydrology"]
doi:10.7717/peerj.5663
77 downloads
294 views

The ε subunit from ATP synthases acts as an ATP sensor in the bacterial cell to prevent ATP hydrolysis and thus the waste of ATP under conditions of low ATP concentration. However, the ATP binding affinities from various bacterial organisms differ markedly, over...

["Biophysics","Computational Biology","Molecular Biology"]
doi:10.7717/peerj.5505
57 downloads
318 views

Background Previous research suggests motion induced fatigue contributes to significant performance degradation and is likely related to a higher incidence of accidents and injuries. However, the exact effect of continuous multidirectional platform perturbations...

["Biophysics","Kinesiology","Metabolic Sciences"]
doi:10.7717/peerj.5439
93 downloads
466 views

The TonB protein plays an essential role in the energy transduction system to drive active transport across the outer membrane (OM) using the proton-motive force of the cytoplasmic membrane of Gram-negative bacteria. The C-terminal domain (CTD) of TonB protein...

["Biochemistry","Biophysics","Microbiology"]
doi:10.7717/peerj.5412
202 downloads
1,088 views

The CHARMM36 force field for lipids is widely used in simulations of lipid bilayers. The CHARMM family of force fields were developed for use with the mTIP3P water model. This water model has an anomalously high dielectric constant and low viscosity, which limits...

["Biochemistry","Biophysics","Computational Biology"]
doi:10.7717/peerj.5472
133 downloads
477 views

Cecropins, originally found in insects, are a group of cationic antimicrobial peptides. Most cecropins have an amphipathic N-terminal segment and a largely hydrophobic C-terminal segment, and normally form a helix-hinge-helix structure. In this study, we developed...

["Biochemistry","Biophysics"]
doi:10.7717/peerj.5369

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