Peer-reviewed Articles - Biology

43 downloads
187 views

The ε subunit from ATP synthases acts as an ATP sensor in the bacterial cell to prevent ATP hydrolysis and thus the waste of ATP under conditions of low ATP concentration. However, the ATP binding affinities from various bacterial organisms differ markedly, over...

["Biophysics","Computational Biology","Molecular Biology"]
doi:10.7717/peerj.5505
33 downloads
205 views

Background Previous research suggests motion induced fatigue contributes to significant performance degradation and is likely related to a higher incidence of accidents and injuries. However, the exact effect of continuous multidirectional platform perturbations...

["Biophysics","Kinesiology","Metabolic Sciences"]
doi:10.7717/peerj.5439
55 downloads
249 views

The TonB protein plays an essential role in the energy transduction system to drive active transport across the outer membrane (OM) using the proton-motive force of the cytoplasmic membrane of Gram-negative bacteria. The C-terminal domain (CTD) of TonB protein...

["Biochemistry","Biophysics","Microbiology"]
doi:10.7717/peerj.5412
123 downloads
818 views

The CHARMM36 force field for lipids is widely used in simulations of lipid bilayers. The CHARMM family of force fields were developed for use with the mTIP3P water model. This water model has an anomalously high dielectric constant and low viscosity, which limits...

["Biochemistry","Biophysics","Computational Biology"]
doi:10.7717/peerj.5472
79 downloads
361 views

Cecropins, originally found in insects, are a group of cationic antimicrobial peptides. Most cecropins have an amphipathic N-terminal segment and a largely hydrophobic C-terminal segment, and normally form a helix-hinge-helix structure. In this study, we developed...

["Biochemistry","Biophysics"]
doi:10.7717/peerj.5369
110 downloads
517 views

Late embryogenesis abundant (LEA) proteins accumulate in plants during adverse conditions and their main attributed function is to confer tolerance to stress. One of the deleterious effects of the adverse environment is the accumulation of metal ions to levels...

["Biochemistry","Biophysics","Plant Science"]
doi:10.7717/peerj.4930
108 downloads
577 views

Elucidating the molecular mechanism of helix–coil transitions of short peptides is a long-standing conundrum in physical chemistry. Although the helix–coil transitions of poly-glutamic acid (PGA) have been extensively studied, the molecular details of its unfolding...

["Biophysics","Computational Biology"]
doi:10.7717/peerj.4769
110 downloads
457 views

Background 1,4-dihydropyridines (1,4-DHP) possesses important biochemical and pharmacological properties, including antioxidant and antimutagenic activities. It was shown that the antimutagenic 1,4-dihydropyridine AV-153-Na interacts with DNA. The aim of the current...

["Biophysics","Cell Biology","Molecular Biology"]
doi:10.7717/peerj.4609
112 downloads
923 views

Background There is convincing evidence for the benefits of resistance training on vertical jump improvements, but little evidence to guide optimal training prescription. The inability to detect small between modality effects may partially reflect the use of ANOVA...

["Biophysics","Kinesiology"]
doi:10.7717/peerj.4620
1 citation
142 downloads
716 views

The palm borer moth Paysandisia archon (Castniidae; giant butterfly-moths) has brown dorsal forewings and strikingly orange-coloured dorsal hindwings with white spots surrounded by black margins. Here, we have studied the structure and pigments of the wing scales...

["Biophysics","Entomology"]
doi:10.7717/peerj.4590
1 citation
167 downloads
1,029 views

The binding specificity of botulinum neurotoxins (BoNTs) is primarily a consequence of their ability to bind to multiple receptors at the same time. BoNTs consist of three distinct domains, a metalloprotease light chain (LC), a translocation domain (HN) and a receptor-binding...

["Biochemistry","Biophysics","Microbiology"]
doi:10.7717/peerj.4552
1 citation
114 downloads
1,007 views

Objective In the foveola of the eye, photoreceptors and Müller cells with a unique morphology have been described, but little is known about their 3D structure and orientation. Considering that there is an angle-dependent change in the foveolar photoreceptor response...

["Biophysics","Cell Biology","Anatomy and Physiology","Ophthalmology","Histology"]
doi:10.7717/peerj.4482
139 downloads
700 views

The structure-thermodynamics correlation analysis was performed for a series of fluorine- and chlorine-substituted benzenesulfonamide inhibitors binding to several human carbonic anhydrase (CA) isoforms. The total of 24 crystal structures of 16 inhibitors bound...

["Biophysics","Drugs and Devices"]
doi:10.7717/peerj.4412
111 downloads
733 views

Osmolytes and macromolecular crowders have the potential to influence the stability of secondary structure motifs and alter preferences for conserved nucleic acid sequences in vivo. To further understand the cellular function of RNA we observed the effects of a...

["Biochemistry","Biophysics"]
doi:10.7717/peerj.4236
1 citation
249 downloads
1,082 views

Background N-acetylcarnosine (NAC), a dipeptide with powerful antioxidant properties that is extensively used as a pharmaceutical prodrug for the treatment of cataract and acute gastric disease, was investigated by molecular dynamics with the GROMACS program in...

["Bioengineering","Biophysics","Computational Science"]
doi:10.7717/peerj.4270

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