Peer-reviewed Articles - Biology

46 downloads
214 views

Oral squamous cell carcinoma (OSCC) is a major malignant cancer of the head and neck. Long non-coding RNAs (lncRNAs) have emerged as critical regulators during the development and progression of cancers. This study aimed to identify a lncRNA-related signature with...

["Bioinformatics","Oncology","Computational Science"]
doi:10.7717/peerj.5307
116 downloads
783 views

Piwi-interacting RNAs (piRNAs) are the largest class of small non-coding RNAs discovered in germ cells. Identifying piRNAs from small RNA data is a challenging task due to the lack of conserved sequences and structural features of piRNAs. Many programs have been...

["Bioinformatics","Computational Biology","Data Mining and Machine Learning"]
doi:10.7717/peerj.5429
80 downloads
586 views

Characterizing transcriptomes in non-model organisms has resulted in a massive increase in our understanding of biological phenomena. This boon, largely made possible via high-throughput sequencing, means that studies of functional, evolutionary, and population...

["Bioinformatics","Genomics"]
doi:10.7717/peerj.5428
41 downloads
233 views

Analysing the relationships between biomolecules and the genetic diseases is a highly active area of research, where the aim is to identify the genes and their products that cause a particular disease due to functional changes originated from mutations. Biological...

["Bioinformatics","Computational Biology"]
doi:10.7717/peerj.5298
59 downloads
311 views

To detect functional somatic mutations in tumor samples, whole-exome sequencing (WES) is often used for its reliability and relative low cost. RNA-seq, while generally used to measure gene expression, can potentially also be used for identification of somatic mutations....

["Bioinformatics","Genomics"]
doi:10.7717/peerj.5362
64 downloads
352 views

The advent of next-generation sequencing has resulted in transcriptome-based approaches to investigate functionally significant biological components in a variety of non-model organism. This has resulted in the area of “venomics”: a rapidly growing field using...

["Bioinformatics","Data Mining and Machine Learning"]
doi:10.7717/peerj.5361
58 downloads
576 views

Genome sequencing is rapidly being adopted in reference labs and hospitals for bacterial outbreak investigation and diagnostics where time is critical. Seven gene multi-locus sequence typing is a standard tool for broadly classifying samples into sequence types...

["Bioinformatics","Microbiology","Epidemiology"]
doi:10.7717/peerj.5233
60 downloads
704 views

Recent advances in Next-Generation Sequencing (NGS) make comparative analyses of the composition and diversity of whole microbial communities possible at a far greater depth than ever before. This brings new challenges, such as an increased dependence on computation...

["Biodiversity","Bioinformatics","Microbiology"]
doi:10.7717/peerj.5299
49 downloads
241 views

Cadmium (Cd) toxicity seriously affects the growth and development of plants, so studies on uptake, translocation, and accumulation of Cd in plants are crucial for phytoremediation. However, the molecular mechanism of the plant response to Cd stress remains poorly...

["Bioinformatics","Genomics","Molecular Biology","Plant Science"]
doi:10.7717/peerj.5191
84 downloads
274 views

With an unprecedented growth in the biomedical literature, keeping up to date with the new developments presents an immense challenge. Publications are often studied in isolation of the established literature, with interpretation being subjective and often introducing...

["Bioinformatics","Algorithms and Analysis of Algorithms","Data Mining and Machine Learning","Software Engineering","Visual Analytics"]
doi:10.7717/peerj.5047
85 downloads
639 views

Although most of the cervical cancer cases are reported to be closely related to the Human Papillomavirus (HPV) infection, there is a need to study genes that stand up differentially in the final actualization of cervical cancers following HPV infection. In this...

["Bioinformatics","Computational Biology","Pathology","Computational Science","Data Mining and Machine Learning"]
doi:10.7717/peerj.5285
65 downloads
289 views

Introduction Sleep scoring is an important step in the treatment of sleep disorders. Manual annotation of sleep stages is time-consuming and experience-relevant and, therefore, needs to be done using machine learning techniques. Methods Sleep-EDF polysomnography...

["Bioinformatics","Neuroscience","Data Mining and Machine Learning"]
doi:10.7717/peerj.5247
53 downloads
168 views

Missing data are frequently encountered in molecular phylogenetics, but there has been no accurate distance imputation method available for distance-based phylogenetic reconstruction. The general framework for distance imputation is to explore tree space and distance...

["Bioinformatics","Computational Biology","Evolutionary Studies"]
doi:10.7717/peerj.5321
77 downloads
304 views

Background Somatic point substitution mutations in the KRAS proto-oncogene primarily affect codons 12/13 where glycine is converted into other amino acids, and are highly prevalent in pancreatic, colorectal, and non-small cell lung cancers. These cohorts are non-responsive...

["Bioinformatics","Immunology","Oncology"]
doi:10.7717/peerj.5056
112 downloads
390 views

Background Long non-coding RNAs (lncRNAs) play crucial roles in the initiation and progression of renal cell carcinoma (RCC) by competing in binding to miRNAs, and related competitive endogenous RNA (ceRNA) networks have been constructed in several cancers. However,...

["Bioinformatics","Oncology","Urology"]
doi:10.7717/peerj.5124

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