Peer-reviewed Articles - Biology

24 downloads
1,075 views

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), two late onset neurodegenerative diseases, have been shown to share overlapping cellular pathologies and genetic origins. Studies suggest that a hexanucleotide repeat expansion in the first...

["Biochemistry","Biophysics","Molecular Biology"]
doi:10.7717/peerj.5815
18 downloads
154 views

Background Senescence-related impairment of proliferation and differentiation limits the use of dental pulp cells for tissue regeneration. Deletion of sclerostin improves the dentinogenesis regeneration, while its role in dental pulp senescence is unclear. We investigated...

["Biochemistry","Cell Biology","Molecular Biology"]
doi:10.7717/peerj.5808
37 downloads
174 views

Leaves from three varieties of Ficus deltoidea, colloquially termed small- (FDS), medium- (FDM), and big-type leaf (FDB), were subjected to water extraction. The crude extracts were fractionated using water (WF) and ethyl acetate (EAF). The phenolic and flavonoid...

["Biochemistry","Cell Biology","Food Science and Technology","Plant Science","Translational Medicine"]
doi:10.7717/peerj.5694
30 downloads
153 views

Background In the wild, matrinchã (Brycon amazonicus) and tambaqui (Colossoma macropomum) rely strongly on their swimming capacity to perform feeding, migration and reproductive activities. Sustained swimming speed in fishes is performed almost exclusively by aerobic...

["Aquaculture, Fisheries and Fish Science","Biochemistry","Freshwater Biology"]
doi:10.7717/peerj.5719
57 downloads
221 views

Proteins of the DUF866 superfamily are exclusively found in eukaryotic cells. A member of the DUF866 superfamily, C1ORF123, is a human protein found in the open reading frame 123 of chromosome 1. The physiological role of C1ORF123 is yet to be determined. The only...

["Biochemistry","Biophysics","Cell Biology","Molecular Biology"]
doi:10.7717/peerj.5377
50 downloads
240 views

Background Denitrification is one of the main pathways of the N-cycle, during which nitrate is converted to dinitrogen gas, in four consecutive reactions that are each catalyzed by a different metalloenzyme. One of the intermediate metabolites is nitrous oxide,...

["Biochemistry","Marine Biology","Microbiology","Aquatic and Marine Chemistry","Biological Oceanography"]
doi:10.7717/peerj.5603
56 downloads
206 views

Two novel peptides belonging to the dermaseptin family, namely DRS-CA-1 and DRS-DU-1, were encoded from cDNA libraries derived from the skin secretions of Phyllomedusa camba and Callimedusa (Phyllomedusa) duellmani. Both natural peptides are highly-conserved and...

["Biochemistry","Bioengineering","Molecular Biology","Synthetic Biology"]
doi:10.7717/peerj.5635
45 downloads
337 views

Plant flavonoid metabolism has served as a platform for understanding a range of fundamental biological phenomena, including providing some of the early insights into the subcellular organization of metabolism. Evidence assembled over the past three decades points...

["Biochemistry","Cell Biology","Plant Science"]
doi:10.7717/peerj.5598
53 downloads
266 views

The processes of association and dissociation of ribosomal subunits are of great importance for the protein biosynthesis. The mechanistic details of these processes, however, are not well known. In bacteria, upon translation termination, the ribosome dissociates...

["Biochemistry","Molecular Biology"]
doi:10.7717/peerj.5620
100 downloads
443 views

Bioluminescent copepods are often the most abundant marine zooplankton and play critical roles in oceanic food webs. Metridia copepods exhibit particularly bright bioluminescence, and the molecular basis of their light production has just recently begun to be explored....

["Biochemistry","Evolutionary Studies","Genomics","Marine Biology","Zoology"]
doi:10.7717/peerj.5506
46 downloads
192 views

Background Abnormal methylation of TNFRSF10C was found to be associated with different types of cancers, excluding colorectal cancer (CRC). In this paper, the performance of TNFRSF10C methylation in CRC was studied in two stages. Method The discovery stage was...

["Biochemistry","Genetics","Molecular Biology","Gastroenterology and Hepatology","Oncology"]
doi:10.7717/peerj.5336
76 downloads
262 views

Background Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder. This study aims to consider effects of resveratrol, exercise and their combination on Farnesoid X receptor (Fxr), the liver X receptor (Lxr) and Sirtuin 1 (Sirt 1) genes...

["Biochemistry","Molecular Biology","Anatomy and Physiology","Metabolic Sciences"]
doi:10.7717/peerj.5522
54 downloads
308 views

GDF11, a member of TGF-β superfamily, has recently received widespread attention as a novel anti-ageing/rejuvenation factor to reverse age-related dysfunctions in heart and skeletal muscle, and to induce angiogenesis and neurogenesis. However, these positive effects...

["Biochemistry","Bioinformatics","Cell Biology","Neuroscience","Evidence Based Medicine"]
doi:10.7717/peerj.5524
73 downloads
378 views

Background Jasmonic acid (JA) and its derivative, methyl JA (MeJA) are hormonal cues released by plants that signal defense response to curb damages from biotic and abiotic stresses. To study such response, a tropical herbal plant, Persicaria minor, which possesses...

["Agricultural Science","Biochemistry","Molecular Biology","Plant Science"]
doi:10.7717/peerj.5525
50 downloads
249 views

Background Strains of periodontal disease-associated bacterium Porphyromonas gingivalis have different pathogenicity, which can be attributed to clonal genetic diversity. P. gingivalis typically expresses two types of fimbriae, FimA and Mfa1, which comprise six...

["Biochemistry","Microbiology","Dentistry"]
doi:10.7717/peerj.5581

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