Peer-reviewed Articles - Biology

23 downloads
125 views

Background Alu is one of the non-autonomous element retrotransposons, constituting nearly 11% of the human DNA. Methylation changes of the Alu element can cause genomic instability, a hallmark of cancer development, ultimately leading to the development of cancer....

["Biochemistry","Anatomy and Physiology","Orthopedics"]
doi:10.7717/peerj.5492
76 downloads
615 views

The CHARMM36 force field for lipids is widely used in simulations of lipid bilayers. The CHARMM family of force fields were developed for use with the mTIP3P water model. This water model has an anomalously high dielectric constant and low viscosity, which limits...

["Biochemistry","Biophysics","Computational Biology"]
doi:10.7717/peerj.5472
56 downloads
315 views

Diacylglycerol kinases (DGKs) are lipid kinases that modulate the levels of lipid second messengers, diacylglycerol and phosphatidic acid. Recently, increasing attention has been paid to its α isozyme (DGKα) as a potential target for cancer immunotherapy. DGKα...

["Biochemistry","Molecular Biology"]
doi:10.7717/peerj.5449
32 downloads
180 views

Background Adult rat epididymal adipocytes are able to convert large amounts of glucose to lactate and glycerol. However, fatty acid efflux is much lower than that expected from glycerol levels if they were the product of lipolysis. Use of glucose for lipogenesis...

["Biochemistry","Diabetes and Endocrinology","Metabolic Sciences"]
doi:10.7717/peerj.5440
39 downloads
170 views

Background Lumbar spinal stenosis (LSS) is a common cause of low back pain with degenerative spinal change in older adults. Telomeres are repetitive nucleoprotein DNA sequences of TTAGGG at the ends of chromosomes. Oxidative stress originates from an imbalance...

["Biochemistry","Geriatrics","Orthopedics"]
doi:10.7717/peerj.5381
43 downloads
204 views

Background Citrus sinensis peels are usually discarded as wastes; however, they are rich sources of Vitamin C, fibre, and many nutrients, including phenolics and flavonoids which are also good antioxidant agents. This study aimed to examine phytochemical composition...

["Biochemistry","Food Science and Technology"]
doi:10.7717/peerj.5331
40 downloads
193 views

Background Bioactive peptides can prevent damage associated with oxidative stress in humans when consumed regularly. Recently, peptides have attracted immense interest because of their beneficial functional properties, safety and little or no side effects when...

["Agricultural Science","Biochemistry","Food Science and Technology"]
doi:10.7717/peerj.5337
59 downloads
290 views

Synechocystis gathered momentum in modelling studies and biotechnological applications owing to multiple factors like fast growth, ability to fix carbon dioxide into valuable products, and the relative ease of genetic manipulation. Synechocystis physiology and...

["Biochemistry","Biotechnology","Cell Biology","Mathematical Biology","Computational Science"]
doi:10.7717/peerj.5256
63 downloads
283 views

Cecropins, originally found in insects, are a group of cationic antimicrobial peptides. Most cecropins have an amphipathic N-terminal segment and a largely hydrophobic C-terminal segment, and normally form a helix-hinge-helix structure. In this study, we developed...

["Biochemistry","Biophysics"]
doi:10.7717/peerj.5369
48 downloads
388 views

This study aimed to characterize the antioxidant properties of Rama Forte persimmon, a tannin-rich fruit variety produced in Brazil. Extracts prepared with lyophilized pulps from fruits obtained in local markets were analyzed individually to evaluate the extent...

["Biochemistry","Food Science and Technology","Nutrition"]
doi:10.7717/peerj.5223
85 downloads
353 views

Background We have previously reported anticancer activities of Melicope ptelefolia (MP) leaf extracts on four different cancer cell lines. However, the underlying mechanisms of actions have yet to be deciphered. In the present study, the anticancer activity of...

["Biochemistry","Biotechnology","Oncology"]
doi:10.7717/peerj.5203
76 downloads
372 views

Army ants are keystone species in many tropical ecosystems. Yet, little is known about the chemical compounds involved in army ant communication. In the present study, we analyzed the volatile mandibular gland secretions—triggers of ant alarm responses—of six Neotropical...

["Biochemistry","Evolutionary Studies","Zoology"]
doi:10.7717/peerj.5319
89 downloads
288 views

Pleurotus tuoliensis, a kind of valuable and favorable edible mushroom in China, is always subjected to high environmental temperature during cultivation. In our previous study with P. tuoliensis, trehalose proved to be effective for tolerating heat stress. Trehalose-6-phosphate...

["Agricultural Science","Biochemistry","Biotechnology","Microbiology","Molecular Biology"]
doi:10.7717/peerj.5230
62 downloads
442 views

Acinus is an abundant nuclear protein involved in apoptosis and splicing. It has been implicated in inducing apoptotic chromatin condensation and DNA fragmentation during programmed cell death. Acinus undergoes activation by proteolytic cleavage that produces a...

["Biochemistry","Molecular Biology"]
doi:10.7717/peerj.5163
119 downloads
763 views

Many proteins display complex dynamical properties that are often intimately linked to their biological functions. As the native state of a protein is best described as an ensemble of conformations, it is important to be able to generate models of native state...

["Biochemistry","Computational Biology"]
doi:10.7717/peerj.5125

Refine by manuscript type

Top subject areas - Articles

Top subject areas - People

View all subject areas