Peer-reviewed Articles - Medicine

80 downloads
248 views

The low survival rate of cardiac stem cells (CSCs) in the ischemic myocardium is one of the obstacles in ischemic cardiomyopathy cell therapy. The MicroRNA (miR)-21 and one of its target protein, the tensin homolog deleted on chromosome ten (PTEN), contributes...

["Cell Biology","Cardiology","Translational Medicine"]
doi:10.7717/peerj.2859
156 downloads
421 views

Background Subcutaneous adipose tissue is a rich source of adipose tissue macrophages and adipose-derived stem cells which both play a key role in wound repair. While macrophages can be divided into the classically-activated M1 and the alternatively-activated M2...

["Translational Medicine","Metabolic Sciences"]
doi:10.7717/peerj.2824
67 downloads
286 views

Introduction Walking is endorsed as health enhancing and is the most common type of physical activity among older adults. Accelerometers are superior to self-reports when measuring steps, however, if they are to be used by clinicians the validity is of great importance....

["Geriatrics","Kinesiology","Public Health","Translational Medicine"]
doi:10.7717/peerj.2799
63 downloads
383 views

Ficolins can activate the lectin pathway of the complement system that provides innate immune protection against pathogens, marks host cellular debris for clearance, and promotes inflammation. Baseline inflammation increases with aging in a phenomenon known as...

["Immunology","Translational Medicine"]
doi:10.7717/peerj.2705
212 downloads
623 views

Background Human hair follicles are important for the renewal of new hairs and their development. The generation of induced pluripotent stem cells (iPSCs) from hair follicles is easy due to its accessibility and availability. The pluripotent cells derived from...

["Cell Biology","Molecular Biology","Translational Medicine"]
doi:10.7717/peerj.2695
323 downloads
854 views

Purpose The aim of this study was to evaluate the effects of low-volume high-intensity interval training and continuous low to moderate intensity training on quality of life, functional capacity and cardiovascular disease risk factors in cancer survivors. Methods...

["Oncology","Public Health","Translational Medicine"]
doi:10.7717/peerj.2613
116 downloads
355 views

A small molecule named ISRIB has recently been described to enhance memory in rodents. In this study we aimed to test whether ISRIB would reverse learning and memory deficits in the J20 mouse model of human amyloid precursor protein (hAPP) overexpression, a model...

["Animal Behavior","Neuroscience","Cognitive Disorders","Neurology","Translational Medicine"]
doi:10.7717/peerj.2565
107 downloads
357 views

Background Short stature in adult life, a possible consequence of poor perinatal conditions, is associated with higher risk of mortality and social disabilities. We aimed to determine whether low-income, overweight/obese, short-stature (SS) women show alterations...

["Epidemiology","Nutrition","Public Health","Translational Medicine"]
doi:10.7717/peerj.2547
1 citation
414 downloads
734 views

Microfracture surgery may be applied to treat cartilage defects. During the procedure the subchondral bone is penetrated, allowing bone marrow-derived mesenchymal stem cells to migrate towards the defect site and form new cartilage tissue. Microfracture surgery...

["Bioengineering","Orthopedics","Rheumatology","Translational Medicine"]
doi:10.7717/peerj.2243
139 downloads
519 views

Previous studies have shown that platelet concentrates used in conjunction with appropriate growth media enhance osteogenic differentiation of human mesenchymal stromal cells (hMSCs). However, their potential in inducing osteogenesis of hMSCs when cultured in serum...

["Cell Biology","Orthopedics","Translational Medicine"]
doi:10.7717/peerj.2347
2 citations
126 downloads
663 views

Cellular therapies with tolerogenic antigen-presenting cells (tolAPC) show great promise for the treatment of autoimmune diseases and for the prevention of destructive immune responses after transplantation. The methodologies for generating tolAPC vary greatly...

["Clinical Trials","Immunology","Translational Medicine","Computational Science"]
doi:10.7717/peerj.2300
453 downloads
1,076 views

Background: Digital medicine and smartphone-enabled health technologies provide a novel source of human health and human biology data. However, in part due to its intricacies, few methods have been established to analyze and interpret data in this domain. We previously...

["Cardiology","Evidence Based Medicine","Translational Medicine","Statistics","Computational Science"]
doi:10.7717/peerj.2284
131 downloads
1,419 views

Introduction. Most documented rare diseases have genetic origin. Because of their low individual frequency, an initial diagnosis based on phenotypic symptoms is not always easy, as practitioners might never have been exposed to patients suffering from the relevant...

["Bioinformatics","Evidence Based Medicine","Translational Medicine","Science and Medical Education","Computational Science"]
doi:10.7717/peerj.2211
126 downloads
785 views

Background. Significant and/or complete rupture in the musculotendinous junction (MTJ) is a challenging lesion to treat because of the lack of reliable suture methods. Skeletal muscle-derived multipotent stem cell (Sk-MSC) sheet-pellets, which are able to reconstitute...

["Cell Biology","Anatomy and Physiology","Orthopedics","Translational Medicine"]
doi:10.7717/peerj.2231
129 downloads
580 views

Background. Testicular ischemia reperfusion injury (tIRI) is considered the mechanism underlying the pathology of testicular torsion and detorsion. Left untreated, tIRI can induce testis dysfunction, damage to spermatogenesis and possible infertility. In this study,...

["Biochemistry","Molecular Biology","Anatomy and Physiology","Translational Medicine","Urology"]
doi:10.7717/peerj.2195

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