Peer-reviewed Articles - Medicine

58 downloads
247 views

Background Adipose-derived mesenchymal stem cells (ADSCs) have shown great potential in the treatment of various diseases. However, the optimum short-term storage condition of ADSCs in 2∼8 °C is rarely reported. This study aimed at optimizing a short-term storage...

["Biotechnology","Cell Biology","Translational Medicine"]
doi:10.7717/peerj.3301
67 downloads
245 views

Background Treatments that target cancer stem cells play an important role in the controlling and eliminating of tumor initiation as well as in development, progression, and chemotherapy/radiotherapy resistance. In our previous study, we cultured and harvested...

["Oncology","Translational Medicine"]
doi:10.7717/peerj.3233
57 downloads
321 views

Background Individuals with type 2 diabetes are at an increased risk of cardiovascular disease. Alterations in circulating lipid levels, total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglycerides (TG) are heritable...

["Bioinformatics","Genomics","Diabetes and Endocrinology","Translational Medicine","Metabolic Sciences"]
doi:10.7717/peerj.3187
1 citation
86 downloads
372 views

Background Sevoflurane postconditioning (S-post) has similar cardioprotective effects as ischemic preconditioning. However, the underlying mechanism of S-post has not been fully elucidated. Janus kinase signaling transduction/transcription activator (JAK2–STAT3)...

["Anesthesiology and Pain Management","Cardiology","Translational Medicine"]
doi:10.7717/peerj.3196
89 downloads
678 views

Sensitivity of short read DNA-sequencing for gene fusion detection is improving, but is hampered by the significant amount of noise composed of uninteresting or false positive hits in the data. In this paper we describe a tiered prioritisation approach to extract...

["Bioinformatics","Genomics","Oncology","Translational Medicine"]
doi:10.7717/peerj.3166
1 citation
110 downloads
398 views

Background ABO blood group is a hereditary factor of plasma levels of coagulation factor VIII (FVIII) and von Willebrand factor (VWF). Age and gender have been shown to influence FVIII, VWF, fibrinogen (Fbg), and ADAMTS13 (A disintegrin and metalloprotease with...

["Biochemistry","Global Health","Hematology","Translational Medicine"]
doi:10.7717/peerj.3156
137 downloads
364 views

The low survival rate of cardiac stem cells (CSCs) in the ischemic myocardium is one of the obstacles in ischemic cardiomyopathy cell therapy. The MicroRNA (miR)-21 and one of its target protein, the tensin homolog deleted on chromosome ten (PTEN), contributes...

["Cell Biology","Cardiology","Translational Medicine"]
doi:10.7717/peerj.2859
234 downloads
570 views

Background Subcutaneous adipose tissue is a rich source of adipose tissue macrophages and adipose-derived stem cells which both play a key role in wound repair. While macrophages can be divided into the classically-activated M1 and the alternatively-activated M2...

["Translational Medicine","Metabolic Sciences"]
doi:10.7717/peerj.2824
92 downloads
396 views

Introduction Walking is endorsed as health enhancing and is the most common type of physical activity among older adults. Accelerometers are superior to self-reports when measuring steps, however, if they are to be used by clinicians the validity is of great importance....

["Geriatrics","Kinesiology","Public Health","Translational Medicine"]
doi:10.7717/peerj.2799
77 downloads
485 views

Ficolins can activate the lectin pathway of the complement system that provides innate immune protection against pathogens, marks host cellular debris for clearance, and promotes inflammation. Baseline inflammation increases with aging in a phenomenon known as...

["Immunology","Translational Medicine"]
doi:10.7717/peerj.2705
283 downloads
791 views

Background Human hair follicles are important for the renewal of new hairs and their development. The generation of induced pluripotent stem cells (iPSCs) from hair follicles is easy due to its accessibility and availability. The pluripotent cells derived from...

["Cell Biology","Molecular Biology","Translational Medicine"]
doi:10.7717/peerj.2695
395 downloads
1,028 views

Purpose The aim of this study was to evaluate the effects of low-volume high-intensity interval training and continuous low to moderate intensity training on quality of life, functional capacity and cardiovascular disease risk factors in cancer survivors. Methods...

["Oncology","Public Health","Translational Medicine"]
doi:10.7717/peerj.2613
155 downloads
439 views

A small molecule named ISRIB has recently been described to enhance memory in rodents. In this study we aimed to test whether ISRIB would reverse learning and memory deficits in the J20 mouse model of human amyloid precursor protein (hAPP) overexpression, a model...

["Animal Behavior","Neuroscience","Cognitive Disorders","Neurology","Translational Medicine"]
doi:10.7717/peerj.2565
144 downloads
431 views

Background Short stature in adult life, a possible consequence of poor perinatal conditions, is associated with higher risk of mortality and social disabilities. We aimed to determine whether low-income, overweight/obese, short-stature (SS) women show alterations...

["Epidemiology","Nutrition","Public Health","Translational Medicine"]
doi:10.7717/peerj.2547
2 citations
477 downloads
882 views

Microfracture surgery may be applied to treat cartilage defects. During the procedure the subchondral bone is penetrated, allowing bone marrow-derived mesenchymal stem cells to migrate towards the defect site and form new cartilage tissue. Microfracture surgery...

["Bioengineering","Orthopedics","Rheumatology","Translational Medicine"]
doi:10.7717/peerj.2243

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