Peer-reviewed Articles - Medicine

63 downloads
350 views

Interstitial lung disease (ILD) is a severe extra-articular manifestation of rheumatoid arthritis (RA) that is well-defined as a chronic systemic autoimmune disease. A proportion of patients with RA-associated ILD (RA-ILD) develop pulmonary fibrosis (PF), resulting...

["Immunology","Respiratory Medicine","Rheumatology","Statistics"]
doi:10.7717/peerj.3021
74 downloads
342 views

Tuberculosis is considered a leading cause of death worldwide. More than 95% of cases and deaths occur in low- and middle-income countries. In resource-limited countries, hospitals often lack adequate facilities to manage and isolate patients with infectious tuberculosis...

["Microbiology","Infectious Diseases","Public Health","Respiratory Medicine"]
doi:10.7717/peerj.2795
66 downloads
355 views

Introduction One-year mortality in COPD patients is reported to be between 4% and 43%, depending on the group examined. Aim To examine the one-year mortality in COPD patients after severe exacerbation and the correlation between mortality and patients’ characteristics...

["Epidemiology","Internal Medicine","Respiratory Medicine"]
doi:10.7717/peerj.2788
1 citation
89 downloads
335 views

Background Acute lung injury and acute respiratory distress syndrome (ALI/ARDS) is a severe clinical syndrome with mortality rate as high as 30–40%. There is no treatment yet to improve pulmonary endothelial barrier function in patients with severe pulmonary edema....

["Cell Biology","Pharmacology","Respiratory Medicine"]
doi:10.7717/peerj.2712
76 downloads
384 views

Background The aim of this study was to determine the expression stabilities of 12 common internal reference genes for the relative quantitation analysis of target gene expression performed by reverse transcription real-time quantitative polymerase chain reaction...

["Oncology","Respiratory Medicine"]
doi:10.7717/peerj.2763
116 downloads
519 views

Background This study examines the biophysical and preclinical pulmonary activity of synthetic lung surfactants containing novel phospholipase-resistant phosphonolipids or synthetic glycerophospholipids combined with Super Mini-B (S-MB) DATK and/or SP-Css ion-lock...

["Bioengineering","Biophysics","Respiratory Medicine","Synthetic Biology"]
doi:10.7717/peerj.2635
174 downloads
608 views

Introduction Osteoporosis is becoming an impending epidemic in the Asia-Pacific region. The association between risk of osteoporotic fracture (OTPF) and chronic obstructive pulmonary disease (COPD) in East Asian patients is yet to be fully examined. We conducted...

["Epidemiology","Geriatrics","Global Health","Orthopedics","Respiratory Medicine"]
doi:10.7717/peerj.2634
229 downloads
520 views

Background The benefit of maintenance therapy has been confirmed in patients with non-progressing non-small cell lung cancer (NSCLC) after first-line therapy by many trials and meta-analyses. However, since few head-to-head trials between different regimens have...

["Evidence Based Medicine","Oncology","Respiratory Medicine"]
doi:10.7717/peerj.2550
1 citation
221 downloads
1,060 views

Background. Cystic fibrosis (CF) is a genetic disease that results in chronic infections of the lungs. CF patients experience intermittent pulmonary exacerbations (CFPE) that are associated with poor clinical outcomes. CFPE involves an increase in disease symptoms...

["Bioinformatics","Infectious Diseases","Respiratory Medicine"]
doi:10.7717/peerj.2174
2 citations
219 downloads
1,333 views

To characterize temporal patterns of transcriptional activity during normal lung development, we generated genome wide gene expression data for 26 pre- and post-natal time points in three common inbred strains of laboratory mice (C57BL/6J, A/J, and C3H/HeJ). Using...

["Bioinformatics","Developmental Biology","Genomics","Respiratory Medicine"]
doi:10.7717/peerj.2318
141 downloads
563 views

Background. CD8+ T lymphocytes are known to play a critical role in the pathogenesis of chronic obstructive pulmonary disease (COPD). However, systematic analyses of CD8+ T cell (Cytotoxic T cells, Tc) subsets in COPD patients have yet to be well conducted. Methods....

["Allergy and Clinical Immunology","Immunology","Respiratory Medicine"]
doi:10.7717/peerj.2301
86 downloads
869 views

Objectives. The primary objective of this study was to assess the rules governing secondary school pupils’ carriage of inhalers for emergency treatment of asthma in the North East of England. Design. This study was based upon a postal questionnaire survey. Setting....

["Health Policy","Pediatrics","Public Health","Respiratory Medicine","Legal Issues"]
doi:10.7717/peerj.2006
350 downloads
1,053 views

Background. Healthcare workers have an increased risk of latent tuberculosis infection (LTBI), but previous studies suggested that they might be reluctant to accept preventive tuberculosis (TB) treatment. We aimed to examine doctors’ and nurses’ experience of TB...

["Health Policy","Infectious Diseases","Medical Staff, Hospital","Public Health","Respiratory Medicine"]
doi:10.7717/peerj.1738
3 citations
167 downloads
684 views

Background/objectives. This study examines the surface activity, resistance to biophysical inhibition, and pulmonary efficacy of a synthetic lung surfactant containing glycerophospholipids combined with Super Mini-B (S-MB) DATK, a novel and stable molecular mimic...

["Bioengineering","Biophysics","Respiratory Medicine"]
doi:10.7717/peerj.1528
1 citation
251 downloads
1,311 views

Mechanical ventilation (MV) of patients can cause damage to bronchoalveolar epithelium, leading to a sterile inflammatory response, infection and in severe cases sepsis. Limited knowledge is available on the effects of MV on the innate immune defense system in...

["Molecular Biology","Immunology","Respiratory Medicine"]
doi:10.7717/peerj.1483

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