Peer-reviewed Articles - Medicine

52 downloads
288 views

Interstitial lung disease (ILD) is a severe extra-articular manifestation of rheumatoid arthritis (RA) that is well-defined as a chronic systemic autoimmune disease. A proportion of patients with RA-associated ILD (RA-ILD) develop pulmonary fibrosis (PF), resulting...

["Immunology","Respiratory Medicine","Rheumatology","Statistics"]
doi:10.7717/peerj.3021
71 downloads
320 views

Tuberculosis is considered a leading cause of death worldwide. More than 95% of cases and deaths occur in low- and middle-income countries. In resource-limited countries, hospitals often lack adequate facilities to manage and isolate patients with infectious tuberculosis...

["Microbiology","Infectious Diseases","Public Health","Respiratory Medicine"]
doi:10.7717/peerj.2795
61 downloads
332 views

Introduction One-year mortality in COPD patients is reported to be between 4% and 43%, depending on the group examined. Aim To examine the one-year mortality in COPD patients after severe exacerbation and the correlation between mortality and patients’ characteristics...

["Epidemiology","Internal Medicine","Respiratory Medicine"]
doi:10.7717/peerj.2788
1 citation
81 downloads
295 views

Background Acute lung injury and acute respiratory distress syndrome (ALI/ARDS) is a severe clinical syndrome with mortality rate as high as 30–40%. There is no treatment yet to improve pulmonary endothelial barrier function in patients with severe pulmonary edema....

["Cell Biology","Pharmacology","Respiratory Medicine"]
doi:10.7717/peerj.2712
68 downloads
360 views

Background The aim of this study was to determine the expression stabilities of 12 common internal reference genes for the relative quantitation analysis of target gene expression performed by reverse transcription real-time quantitative polymerase chain reaction...

["Oncology","Respiratory Medicine"]
doi:10.7717/peerj.2763
107 downloads
469 views

Background This study examines the biophysical and preclinical pulmonary activity of synthetic lung surfactants containing novel phospholipase-resistant phosphonolipids or synthetic glycerophospholipids combined with Super Mini-B (S-MB) DATK and/or SP-Css ion-lock...

["Bioengineering","Biophysics","Respiratory Medicine","Synthetic Biology"]
doi:10.7717/peerj.2635
164 downloads
573 views

Introduction Osteoporosis is becoming an impending epidemic in the Asia-Pacific region. The association between risk of osteoporotic fracture (OTPF) and chronic obstructive pulmonary disease (COPD) in East Asian patients is yet to be fully examined. We conducted...

["Epidemiology","Geriatrics","Global Health","Orthopedics","Respiratory Medicine"]
doi:10.7717/peerj.2634
218 downloads
465 views

Background The benefit of maintenance therapy has been confirmed in patients with non-progressing non-small cell lung cancer (NSCLC) after first-line therapy by many trials and meta-analyses. However, since few head-to-head trials between different regimens have...

["Evidence Based Medicine","Oncology","Respiratory Medicine"]
doi:10.7717/peerj.2550
1 citation
210 downloads
1,017 views

Background. Cystic fibrosis (CF) is a genetic disease that results in chronic infections of the lungs. CF patients experience intermittent pulmonary exacerbations (CFPE) that are associated with poor clinical outcomes. CFPE involves an increase in disease symptoms...

["Bioinformatics","Infectious Diseases","Respiratory Medicine"]
doi:10.7717/peerj.2174
2 citations
207 downloads
1,253 views

To characterize temporal patterns of transcriptional activity during normal lung development, we generated genome wide gene expression data for 26 pre- and post-natal time points in three common inbred strains of laboratory mice (C57BL/6J, A/J, and C3H/HeJ). Using...

["Bioinformatics","Developmental Biology","Genomics","Respiratory Medicine"]
doi:10.7717/peerj.2318
129 downloads
544 views

Background. CD8+ T lymphocytes are known to play a critical role in the pathogenesis of chronic obstructive pulmonary disease (COPD). However, systematic analyses of CD8+ T cell (Cytotoxic T cells, Tc) subsets in COPD patients have yet to be well conducted. Methods....

["Allergy and Clinical Immunology","Immunology","Respiratory Medicine"]
doi:10.7717/peerj.2301
84 downloads
814 views

Objectives. The primary objective of this study was to assess the rules governing secondary school pupils’ carriage of inhalers for emergency treatment of asthma in the North East of England. Design. This study was based upon a postal questionnaire survey. Setting....

["Health Policy","Pediatrics","Public Health","Respiratory Medicine","Legal Issues"]
doi:10.7717/peerj.2006
303 downloads
968 views

Background. Healthcare workers have an increased risk of latent tuberculosis infection (LTBI), but previous studies suggested that they might be reluctant to accept preventive tuberculosis (TB) treatment. We aimed to examine doctors’ and nurses’ experience of TB...

["Health Policy","Infectious Diseases","Medical Staff, Hospital","Public Health","Respiratory Medicine"]
doi:10.7717/peerj.1738
3 citations
165 downloads
662 views

Background/objectives. This study examines the surface activity, resistance to biophysical inhibition, and pulmonary efficacy of a synthetic lung surfactant containing glycerophospholipids combined with Super Mini-B (S-MB) DATK, a novel and stable molecular mimic...

["Bioengineering","Biophysics","Respiratory Medicine"]
doi:10.7717/peerj.1528
1 citation
245 downloads
1,280 views

Mechanical ventilation (MV) of patients can cause damage to bronchoalveolar epithelium, leading to a sterile inflammatory response, infection and in severe cases sepsis. Limited knowledge is available on the effects of MV on the innate immune defense system in...

["Molecular Biology","Immunology","Respiratory Medicine"]
doi:10.7717/peerj.1483

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