Peer-reviewed Articles - Medicine

32 downloads
246 views

Background Molecularly targeted therapies improved survival status of some patients with lung adenocarcinoma, which accounts for 40% of all lung cancers, and in-depth study of gene alterations is important for the personalized treatment. Methods The legacy archive...

["Genetics","Oncology","Respiratory Medicine","Medical Genetics"]
doi:10.7717/peerj.3216
58 downloads
607 views

Obstructive sleep apnea syndrome (OSAS) is a common clinical condition. The way that OSAS risk factors associate and converge is not a random process. As such, defining OSAS phenotypes fosters personalized patient management and population screening. In this paper,...

["Bioinformatics","Computational Biology","Health Policy","Respiratory Medicine","Computational Science"]
doi:10.7717/peerj.3289
70 downloads
411 views

Interstitial lung disease (ILD) is a severe extra-articular manifestation of rheumatoid arthritis (RA) that is well-defined as a chronic systemic autoimmune disease. A proportion of patients with RA-associated ILD (RA-ILD) develop pulmonary fibrosis (PF), resulting...

["Immunology","Respiratory Medicine","Rheumatology","Statistics"]
doi:10.7717/peerj.3021
83 downloads
372 views

Tuberculosis is considered a leading cause of death worldwide. More than 95% of cases and deaths occur in low- and middle-income countries. In resource-limited countries, hospitals often lack adequate facilities to manage and isolate patients with infectious tuberculosis...

["Microbiology","Infectious Diseases","Public Health","Respiratory Medicine"]
doi:10.7717/peerj.2795
73 downloads
384 views

Introduction One-year mortality in COPD patients is reported to be between 4% and 43%, depending on the group examined. Aim To examine the one-year mortality in COPD patients after severe exacerbation and the correlation between mortality and patients’ characteristics...

["Epidemiology","Internal Medicine","Respiratory Medicine"]
doi:10.7717/peerj.2788
1 citation
99 downloads
367 views

Background Acute lung injury and acute respiratory distress syndrome (ALI/ARDS) is a severe clinical syndrome with mortality rate as high as 30–40%. There is no treatment yet to improve pulmonary endothelial barrier function in patients with severe pulmonary edema....

["Cell Biology","Pharmacology","Respiratory Medicine"]
doi:10.7717/peerj.2712
82 downloads
419 views

Background The aim of this study was to determine the expression stabilities of 12 common internal reference genes for the relative quantitation analysis of target gene expression performed by reverse transcription real-time quantitative polymerase chain reaction...

["Oncology","Respiratory Medicine"]
doi:10.7717/peerj.2763
126 downloads
561 views

Background This study examines the biophysical and preclinical pulmonary activity of synthetic lung surfactants containing novel phospholipase-resistant phosphonolipids or synthetic glycerophospholipids combined with Super Mini-B (S-MB) DATK and/or SP-Css ion-lock...

["Bioengineering","Biophysics","Respiratory Medicine","Synthetic Biology"]
doi:10.7717/peerj.2635
188 downloads
654 views

Introduction Osteoporosis is becoming an impending epidemic in the Asia-Pacific region. The association between risk of osteoporotic fracture (OTPF) and chronic obstructive pulmonary disease (COPD) in East Asian patients is yet to be fully examined. We conducted...

["Epidemiology","Geriatrics","Global Health","Orthopedics","Respiratory Medicine"]
doi:10.7717/peerj.2634
238 downloads
569 views

Background The benefit of maintenance therapy has been confirmed in patients with non-progressing non-small cell lung cancer (NSCLC) after first-line therapy by many trials and meta-analyses. However, since few head-to-head trials between different regimens have...

["Evidence Based Medicine","Oncology","Respiratory Medicine"]
doi:10.7717/peerj.2550
2 citations
242 downloads
1,134 views

Background. Cystic fibrosis (CF) is a genetic disease that results in chronic infections of the lungs. CF patients experience intermittent pulmonary exacerbations (CFPE) that are associated with poor clinical outcomes. CFPE involves an increase in disease symptoms...

["Bioinformatics","Infectious Diseases","Respiratory Medicine"]
doi:10.7717/peerj.2174
2 citations
226 downloads
1,452 views

To characterize temporal patterns of transcriptional activity during normal lung development, we generated genome wide gene expression data for 26 pre- and post-natal time points in three common inbred strains of laboratory mice (C57BL/6J, A/J, and C3H/HeJ). Using...

["Bioinformatics","Developmental Biology","Genomics","Respiratory Medicine"]
doi:10.7717/peerj.2318
153 downloads
597 views

Background. CD8+ T lymphocytes are known to play a critical role in the pathogenesis of chronic obstructive pulmonary disease (COPD). However, systematic analyses of CD8+ T cell (Cytotoxic T cells, Tc) subsets in COPD patients have yet to be well conducted. Methods....

["Allergy and Clinical Immunology","Immunology","Respiratory Medicine"]
doi:10.7717/peerj.2301
88 downloads
914 views

Objectives. The primary objective of this study was to assess the rules governing secondary school pupils’ carriage of inhalers for emergency treatment of asthma in the North East of England. Design. This study was based upon a postal questionnaire survey. Setting....

["Health Policy","Pediatrics","Public Health","Respiratory Medicine","Legal Issues"]
doi:10.7717/peerj.2006
368 downloads
1,133 views

Background. Healthcare workers have an increased risk of latent tuberculosis infection (LTBI), but previous studies suggested that they might be reluctant to accept preventive tuberculosis (TB) treatment. We aimed to examine doctors’ and nurses’ experience of TB...

["Health Policy","Infectious Diseases","Medical Staff, Hospital","Public Health","Respiratory Medicine"]
doi:10.7717/peerj.1738

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