Peer-reviewed Articles - Medicine

33 downloads
320 views

Background & Aims Metformin is currently the most widely used first-line hypoglycemic agent for diabetes mellitus. Besides glucose-lowering action, there is increasingly interest in the potential anti-inflammatory action of this drug. In the present study, we investigated...

["Diabetes and Endocrinology","Pharmacology"]
doi:10.7717/peerj.3155
56 downloads
253 views

Objective This study aimed to quantify the cartilage- and subchondral bone-related effects of low-dose and high-dose meloxicam treatment in the late phase of mono-iodoacetate-induced osteoarthritis of the stifle. Methods Thirty-four male Wistar rats received intra-articular...

["Pathology","Pharmacology","Rheumatology","Histology"]
doi:10.7717/peerj.3185
52 downloads
291 views

Background Resveratrol is a cardioprotective agent with known antiarrhythmic effects that has recently been shown to inhibit phosphodiesterase (PDE) enzyme activity. Thus, it is possible that resveratrol increases the inotropic effect of sympathomimetic agents,...

["Cardiology","Drugs and Devices","Pharmacology"]
doi:10.7717/peerj.3113
59 downloads
319 views

Apoptosis of lymphocytes is associated with immunosuppression and poor prognosis in sepsis. Our previous report showed that histones, nuclear proteins released from damaged or dying cells in sepsis, can mediate lymphocyte apoptosis via mitochondria damage. Grape...

["Cell Biology","Immunology","Pharmacology"]
doi:10.7717/peerj.3108
1,445 downloads
10,783 views

Importance Case reports describe persistent erectile dysfunction (PED) associated with exposure to 5α-reductase inhibitors (5α-RIs). Clinical trial reports and the manufacturers’ full prescribing information (FPI) for finasteride and dutasteride state that risk...

["Dermatology","Epidemiology","Internal Medicine","Pharmacology","Urology"]
doi:10.7717/peerj.3020
64 downloads
314 views

Background To find the best individual chemotherapy for cancer patients, the efficacy of different chemotherapeutic drugs can be predicted by pretesting tumor samples in vitro via the chemotherapy-resistance (CTR)-Test®. Although drug combinations are widely used...

["Gynecology and Obstetrics","Oncology","Pharmacology"]
doi:10.7717/peerj.3030
106 downloads
948 views

Modafinil (2-((diphenylmethyl)sulfinyl)acetamide), a selective dopamine and norepinephrine transporter inhibitor, is most commonly prescribed for narcolepsy but has gained recent interest for treating a variety of disorders. Zebrafish (Danio rerio) are becoming...

["Animal Behavior","Aquaculture, Fisheries and Fish Science","Neuroscience","Pharmacology"]
doi:10.7717/peerj.2994
70 downloads
254 views

Maximakinin (MK), an amphibian peptide possessing the C-terminal sequence of bradykinin (BK), is a BK B2 receptor (B2R) agonist eliciting prolonged signaling. We reinvestigated this 19-mer for species-specific pharmacologic profile, in vivo confirmation of resistance...

["Cardiology","Pharmacology"]
doi:10.7717/peerj.2911
65 downloads
288 views

The fibrosis that develops following laminectomy or discectomy often causes serious complications, and the proliferation of fibroblasts is thought to be the major cause of epidural fibrosis. 10-Hydroxycamptothecin (HCPT) has been proven to be efficient in preventing...

["Cell Biology","Orthopedics","Pharmacology","Histology"]
doi:10.7717/peerj.2858
67 downloads
428 views

Background There is a dearth of drugs to manage a dose-limiting painful peripheral neuropathy induced by paclitaxel in some patients during the treatment of cancer. Gamma-aminobutyric acid transporter-1 (GAT-1) whose expression is increased in the brain and spinal...

["Animal Behavior","Neuroscience","Anaesthesiology and Pain Management","Pharmacology"]
doi:10.7717/peerj.2798
128 downloads
403 views

Major research efforts have been devoted to the discovery and development of new chemical entities that could inhibit the protein–protein interaction between HIF-1α and the von Hippel–Lindau protein (pVHL), which serves as the substrate recognition subunit of an...

["Biochemistry","Computational Biology","Pharmacology"]
doi:10.7717/peerj.2757
136 downloads
391 views

Background Neuronal and synaptic loss is the most important risk factor for cognitive impairment. Inhibiting neuronal apoptosis and preventing synaptic loss are promising therapeutic approaches for Alzheimer’s disease (AD). In this study, we investigate the protective...

["Neuroscience","Drugs and Devices","Pharmacology"]
doi:10.7717/peerj.2739
1 citation
89 downloads
335 views

Background Acute lung injury and acute respiratory distress syndrome (ALI/ARDS) is a severe clinical syndrome with mortality rate as high as 30–40%. There is no treatment yet to improve pulmonary endothelial barrier function in patients with severe pulmonary edema....

["Cell Biology","Pharmacology","Respiratory Medicine"]
doi:10.7717/peerj.2712
108 downloads
461 views

Background T cells play a pivotal role in the adaptive immunity that participates in a wide range of immune responses through a complicated cytokine network. Imbalance of T-cell responses is involved in several immune disorders. Neolitsea species, one of the biggest...

["Cell Biology","Food Science and Technology","Immunology","Pharmacology"]
doi:10.7717/peerj.2758
106 downloads
521 views

Background Licorice, a popular traditional Chinese medicine (TCM), is widely used to moderate the effects (detoxification) of other herbs in TCM and often combined with Fructus Psoraleae. However, the classical TCM book states that Fructus Psoraleae is incompatible...

["Cell Biology","Toxicology","Pharmacology"]
doi:10.7717/peerj.2723

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