Peer-reviewed Articles - Medicine

15 downloads
112 views

Background Meningiomas are common intracranial tumors in humans that frequently recur despite having a predominantly benign nature. Even though these tumors have been shown to commonly express EGFR/c-erbB1 (epidermal growth factor receptor), results from previous...

["Oncology","Pathology","Histology"]
doi:10.7717/peerj.3140
80 downloads
454 views

Background Liver hepatocellular carcinoma accounts for the overwhelming majority of primary liver cancers and its belated diagnosis and poor prognosis call for novel biomarkers to be discovered, which, in the era of big data, innovative bioinformatics and computational...

["Bioinformatics","Computational Biology","Oncology","Pathology","Surgery and Surgical Specialties"]
doi:10.7717/peerj.3089
148 downloads
808 views

Foot problems are a major cause of morbidity and mortality in elephants, but are underreported due to difficulties in diagnosis, particularly of conditions affecting the bones and internal structures. Here we evaluate post-mortem computer tomographic (CT) scans...

["Veterinary Medicine","Pathology","Radiology and Medical Imaging"]
doi:10.7717/peerj.2877
95 downloads
264 views

Background Daldinia eschscholtzii is a filamentous wood-inhabiting endophyte commonly found in woody plants. Here, we report the identification and characterization of nine D. eschscholtzii isolates from skin scrapings, nail clippings, and blood. Methods The nine...

["Mycology","Infectious Diseases","Pathology"]
doi:10.7717/peerj.2637
66 downloads
351 views

Tissue microarrays are commonly used in modern pathology for cancer tissue evaluation, as it is a very potent technique. Tissue microarray slides are often scanned to perform computer-aided histopathological analysis of the tissue cores. For processing the image,...

["Computational Biology","Pathology","Histology"]
doi:10.7717/peerj.2741
93 downloads
298 views

We characterized a novel GJB2 missense variant, c.133G>A, p.Gly45Arg, and compared it with the only other variant at the same amino acid position of the connexin 26 protein (Cx26) reported to date: c.134G>A, p.Gly45Glu. Whereas both variants are associated with...

["Molecular Biology","Otorhinolaryngology","Pathology"]
doi:10.7717/peerj.2494
386 downloads
730 views

N-Acetyl-p-Aminophenol (APAP), also known as acetaminophen, is the most commonly used over-the counter analgesic and antipyretic medication. However, its overdose leads to both liver and kidney damage. APAP-induced toxicity is considered as one of the primary causes...

["Food Science and Technology","Neuroscience","Toxicology","Pathology","Pharmacology"]
doi:10.7717/peerj.2127
97 downloads
626 views

Histopathology tissue archives can be an important source of specimens for retrospective studies, as these include samples covering a large number of diseases. In veterinary medicine, archives also contain samples from a large variety of species and may represent...

["Molecular Biology","Veterinary Medicine","Pathology"]
doi:10.7717/peerj.1996
1 citation
310 downloads
890 views

Information is lacking on preserving fish carcasses to minimize postmortem autolysis artifacts when a necropsy cannot be performed immediately. The purpose of this study was to qualitatively identify and score histologic postmortem changes in two species of freshwater...

["Aquaculture, Fisheries and Fish Science","Pathology"]
doi:10.7717/peerj.1943
1 citation
242 downloads
896 views

MicroRNAs (miRNAs) are negative regulators of gene expression and protein abundance. Current evidence shows an association of miRNAs with acute kidney injury (AKI) leading to substantially increased morbidity and mortality. Here, we investigated whether miRNAs...

["Cell Biology","Nephrology","Pathology"]
doi:10.7717/peerj.1729
243 downloads
797 views

Purpose. Type 2 diabetes is the leading cause of end stage renal disease in the United States. Atherosclerotic renal artery stenosis is commonly observed in diabetic patients and impacts the rate of renal and cardiovascular disease progression. We sought to test...

["Cardiology","Diabetes and Endocrinology","Nephrology","Pathology","Translational Medicine"]
doi:10.7717/peerj.1736
320 downloads
944 views

Microbubbles (MBs) are considered as an important enhancer for high intensity focused ultrasound (HIFU) treatment of benign or malignant tumors. Recently, different sizes of gas-filled bubbles have been investigated to improve the therapeutic efficiency of HIFU...

["Bioengineering","Oncology","Pathology","Radiology and Medical Imaging"]
doi:10.7717/peerj.1716
421 downloads
922 views

Experimental autoimmune encephalomyelitis (EAE) is a well-established mouse model for multiple sclerosis and is characterized by infiltration of mononuclear cells and demyelination within the central nervous system along with the clinical symptoms of paralysis....

["Neurology","Pathology","Histology"]
doi:10.7717/peerj.1600
399 downloads
1,371 views

Phenotypic characterization of cellular responses in equine infectious encephalitides has had limited description of both peripheral and resident cell populations in central nervous system (CNS) tissues due to limited species-specific reagents that react with formalin-fixed,...

["Veterinary medicine","Infectious diseases","Pathology","Histology"]
doi:10.7717/peerj.1601
7 citations
877 downloads
4,340 views

Adult large-bodied theropods are often found with numerous pathologies. A large, almost complete, probably adult Allosaurus specimen from the Howe Stephens Quarry, Morrison Formation (Late Kimmeridgian–Early Tithonian), Wyoming, exhibits multiple pathologies. Pathologic...

["Animal Behavior","Paleontology","Veterinary Medicine","Zoology","Pathology"]
doi:10.7717/peerj.940

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