Peer-reviewed Articles - Medicine

44 downloads
214 views

Small interference RNA has been widely used to suppress gene expression. Three different short hairpin RNAs (shRNAs) against dopamine D1 receptor (Drd1), driven by mouse U6 promoter in self-complementary AAV8 vector (scAAV8), were used to silence mouse striatal...

["Neuroscience","Neurology","Pathology"]
doi:10.7717/peerj.3905
281 downloads
1,876 views

Mammals as a rule have seven cervical vertebrae, a number that remains remarkably constant. Changes of this number are associated with major congenital abnormalities (pleiotropic effects) that are, at least in humans, strongly selected against. Recently, it was...

["Ecology","Evolutionary Studies","Paleontology","Veterinary Medicine","Pathology"]
doi:10.7717/peerj.3684
61 downloads
334 views

Disturbance from the normal developmental trajectory of a trait during growth—the so-called developmental instability—can be observed morphologically through phenodeviants and subtle deviations from perfect symmetry (fluctuating asymmetry). This study investigates...

["Developmental Biology","Evolutionary Studies","Zoology","Anatomy and Physiology","Pathology"]
doi:10.7717/peerj.3359
160 downloads
396 views

Objectives The purpose of this study is to determine the prevalence and clinical impact of human papillomavirus (HPV) related laryngeal squamous cell carcinoma (LSCC). Methods A total of 106 LSCC patients who underwent primary surgical resection with or without...

["Oncology","Otorhinolaryngology","Pathology"]
doi:10.7717/peerj.3395
97 downloads
377 views

Background Electrolytic ablation and electroporation based ablation are minimally invasive, non-thermal surgical technologies that employ electrical currents and electric fields to ablate undesirable cells in a volume of tissue. In this study, we explore the attributes...

["Bioengineering","Biophysics","Oncology","Pathology","Histology"]
doi:10.7717/peerj.3190
211 downloads
701 views

Objective This study aimed to quantify the cartilage- and subchondral bone-related effects of low-dose and high-dose meloxicam treatment in the late phase of mono-iodoacetate-induced osteoarthritis of the stifle. Methods Thirty-four male Wistar rats received intra-articular...

["Pathology","Pharmacology","Rheumatology","Histology"]
doi:10.7717/peerj.3185
1 citation
146 downloads
490 views

The identification of Parrot bornaviruses (PaBV) in psittacine birds with proventricular dilatation disease (PDD) has not been sufficient to explain the pathogenesis of this fatal disease, since not all infected birds develop clinical signs. Although the most accepted...

["Veterinary Medicine","Virology","Pathology"]
doi:10.7717/peerj.3144
128 downloads
595 views

Background Meningiomas are common intracranial tumors in humans that frequently recur despite having a predominantly benign nature. Even though these tumors have been shown to commonly express EGFR/c-erbB1 (epidermal growth factor receptor), results from previous...

["Oncology","Pathology","Histology"]
doi:10.7717/peerj.3140
296 downloads
1,133 views

Background Liver hepatocellular carcinoma accounts for the overwhelming majority of primary liver cancers and its belated diagnosis and poor prognosis call for novel biomarkers to be discovered, which, in the era of big data, innovative bioinformatics and computational...

["Bioinformatics","Computational Biology","Oncology","Pathology","Surgery and Surgical Specialties"]
doi:10.7717/peerj.3089
1 citation
301 downloads
1,142 views

Foot problems are a major cause of morbidity and mortality in elephants, but are underreported due to difficulties in diagnosis, particularly of conditions affecting the bones and internal structures. Here we evaluate post-mortem computer tomographic (CT) scans...

["Veterinary Medicine","Pathology","Radiology and Medical Imaging"]
doi:10.7717/peerj.2877
1 citation
151 downloads
510 views

Background Daldinia eschscholtzii is a filamentous wood-inhabiting endophyte commonly found in woody plants. Here, we report the identification and characterization of nine D. eschscholtzii isolates from skin scrapings, nail clippings, and blood. Methods The nine...

["Mycology","Infectious Diseases","Pathology"]
doi:10.7717/peerj.2637
116 downloads
501 views

Tissue microarrays are commonly used in modern pathology for cancer tissue evaluation, as it is a very potent technique. Tissue microarray slides are often scanned to perform computer-aided histopathological analysis of the tissue cores. For processing the image,...

["Computational Biology","Pathology","Histology"]
doi:10.7717/peerj.2741
1 citation
173 downloads
498 views

We characterized a novel GJB2 missense variant, c.133G>A, p.Gly45Arg, and compared it with the only other variant at the same amino acid position of the connexin 26 protein (Cx26) reported to date: c.134G>A, p.Gly45Glu. Whereas both variants are associated with...

["Molecular Biology","Otorhinolaryngology","Pathology"]
doi:10.7717/peerj.2494
1 citation
601 downloads
975 views

N-Acetyl-p-Aminophenol (APAP), also known as acetaminophen, is the most commonly used over-the counter analgesic and antipyretic medication. However, its overdose leads to both liver and kidney damage. APAP-induced toxicity is considered as one of the primary causes...

["Food Science and Technology","Neuroscience","Toxicology","Pathology","Pharmacology"]
doi:10.7717/peerj.2127
129 downloads
785 views

Histopathology tissue archives can be an important source of specimens for retrospective studies, as these include samples covering a large number of diseases. In veterinary medicine, archives also contain samples from a large variety of species and may represent...

["Molecular Biology","Veterinary Medicine","Pathology"]
doi:10.7717/peerj.1996

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