Peer-reviewed Articles - Medicine

14 downloads
139 views

The past two decades have brought many important advances in our understanding of the hereditary susceptibility to cancer. Numerous studies have provided convincing evidence that identification of germline mutations associated with hereditary cancer syndromes can...

["Genomics","Oncology","Medical Genetics"]
doi:10.7717/peerj.3046
52 downloads
399 views

Background Colorectal cancer (CRC) is one of the leading cancers worldwide. Several studies have performed microarray data analyses for cancer classification and prognostic analyses. Microarray assays also enable the identification of gene signatures for molecular...

["Bioinformatics","Mathematical Biology","Molecular Biology","Oncology","Statistics"]
doi:10.7717/peerj.3003
35 downloads
193 views

Background The current TNM classification system does not consider tumor length for patients with esophageal carcinoma (EC). This study explored the effect of tumor length, in addition to tumor depth and lymph node involvement, on survival in patients with esophageal...

["Oncology","Surgery and Surgical Specialties"]
doi:10.7717/peerj.2943
54 downloads
235 views

Background Multiple myeloma is a cancer which has a high occurrence rate and causes great injury to people worldwide. In recent years, many studies reported the effects of miRNA on the appearance of multiple myeloma. However, due to the differences of samples and...

["Genomics","Dermatology","Oncology"]
doi:10.7717/peerj.2831
42 downloads
183 views

Background Platinum-based agents are widely used in chemotherapy against solid tumors and insufficient intracellular drug accumulation is one of the leading causes of platinum resistance which is associated with poor survival of tumor patients. Thus, the detection...

["Cell Biology","Drugs and Devices","Oncology"]
doi:10.7717/peerj.2873
46 downloads
149 views

Background Cryoelectrolysis is a new minimally invasive tissue ablation surgical technique that combines the ablation techniques of electrolytic ablation with cryosurgery. The goal of this study is to examine the hypothesis that electrolysis can take place in a...

["Biochemistry","Bioengineering","Biophysics","Oncology","Surgery and Surgical Specialties"]
doi:10.7717/peerj.2810
35 downloads
184 views

Previous studies have investigated the association between cytotoxic T-lymphocyte antigen-4 (CTLA-4) polymorphisms and breast cancer susceptibility, but the results remained inconsistent. Therefore, we evaluated the relationship between four common CTLA-4 polymorphisms...

["Evidence Based Medicine","Oncology","Medical Genetics"]
doi:10.7717/peerj.2815
62 downloads
262 views

The incidence of cutaneous melanoma (CM) has rapidly increased over the past four decades. CM is often overlooked in East Asian populations due to its low incidence, despite East Asia making up 22% of the world’s population. Since the 1990s, Caucasian populations...

["Dermatology","Epidemiology","Oncology","Public Health"]
doi:10.7717/peerj.2809
181 downloads
400 views

This large-scale, controlled cohort study estimated the risks of lung cancer in patients with gastro-esophageal reflux disease (GERD) in Taiwan. We conducted this population-based study using data from the National Health Insurance Research Database of Taiwan during...

["Epidemiology","Gastroenterology and Hepatology","Oncology"]
doi:10.7717/peerj.2753
84 downloads
402 views

Background Our study aimed to compare the outcomes of surgical treatment of tongue cancer patients in three different age groups. Methods From 2004 to 2013, we retrospectively analyzed the clinical data of 1,712 patients who were treated in the four institutions...

["Geriatrics","Oncology","Otorhinolaryngology","Surgery and Surgical Specialties"]
doi:10.7717/peerj.2794
60 downloads
320 views

Background The aim of this study was to determine the expression stabilities of 12 common internal reference genes for the relative quantitation analysis of target gene expression performed by reverse transcription real-time quantitative polymerase chain reaction...

["Oncology","Respiratory Medicine"]
doi:10.7717/peerj.2763
130 downloads
383 views

MicroRNAs (miRNAs) may promote the development and progression of human cancers. Therefore, components of the miRNA biogenesis pathway may play critical roles in human cancer. Single nucleotide polymorphisms (SNPs) or mutations in genes involved in the miRNA biogenesis...

["Genetics","Epidemiology","Evidence Based Medicine","Oncology"]
doi:10.7717/peerj.2706
225 downloads
514 views

Lithocholic acid (LCA) is a secondary bile acid that is selectively toxic to human neuroblastoma, breast and prostate cancer cells, whilst sparing normal cells. We previously reported that LCA inhibited cell viability and proliferation and induced apoptosis and...

["Toxicology","Oncology"]
doi:10.7717/peerj.2445
288 downloads
771 views

Purpose The aim of this study was to evaluate the effects of low-volume high-intensity interval training and continuous low to moderate intensity training on quality of life, functional capacity and cardiovascular disease risk factors in cancer survivors. Methods...

["Oncology","Public Health","Translational Medicine"]
doi:10.7717/peerj.2613
207 downloads
410 views

Background The benefit of maintenance therapy has been confirmed in patients with non-progressing non-small cell lung cancer (NSCLC) after first-line therapy by many trials and meta-analyses. However, since few head-to-head trials between different regimens have...

["Evidence Based Medicine","Oncology","Respiratory Medicine"]
doi:10.7717/peerj.2550

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