Peer-reviewed Articles - Medicine

19 downloads
170 views

The death-associated protein kinase 1 (DAPK1) can act as an oncogene or a tumor suppressor gene depending on the cellular context as well as external stimuli. Our study aims to investigate the prognostic significance of DAPK1 in liver cancer in both mRNA and protein...

["Biochemistry","Gastroenterology and Hepatology","Oncology","Translational Medicine","Histology"]
doi:10.7717/peerj.3568
22 downloads
162 views

Background As the fifth most common cancer worldwide, Hepatocellular carcinoma (HCC) is also the third most common cause of cancer-related death in China. Several lncRNAs have been demonstrated to be associated with occurrence and prognosis of HCC. However, identification...

["Bioinformatics","Molecular Biology","Gastroenterology and Hepatology","Oncology"]
doi:10.7717/peerj.3575
25 downloads
173 views

Gastric cancer (GC) is a complex disease with heterogeneous genetic mechanisms. Genomic mutational profiling of gastric cancer not only expands our knowledge about cancer progression at a fundamental genetic level, but also could provide guidance on new treatment...

["Computational Biology","Genomics","Oncology"]
doi:10.7717/peerj.3585
78 downloads
334 views

Aim To investigate the association of C-MYC protein expression and risk stratification in mantle cell lymphoma (MCL), and to evaluate the utility of C-MYC protein as a prognostic biomarker in clinical practice. Methods We conducted immunohistochemical staining...

["Hematology","Oncology"]
doi:10.7717/peerj.3457
87 downloads
392 views

TH(AGYLLGHINLHHLAHL(Aib)HHIL-NH2), a histidine-rich, cell-penetrating peptide with acid-activated pH response, designed and synthesized by our group, can effectively target tumor tissues with an acidic extracellular environment. Since the protonating effect of...

["Biochemistry","Cell Biology","Oncology"]
doi:10.7717/peerj.3429
70 downloads
384 views

The changes of protein expression that are monitored in proteomic experiments are a type of biological transformation that also involves changes in chemical composition. Accompanying the myriad molecular-level interactions that underlie any proteomic transformation,...

["Biochemistry","Mathematical Biology","Oncology"]
doi:10.7717/peerj.3421
105 downloads
377 views

Gastric cancer is an aggressive cancer that is often diagnosed late. Early detection and treatment require a better understanding of the molecular pathology of the disease. The present study combined data on gene expression and regulatory levels (microRNA, methylation,...

["Bioinformatics","Genetics","Genomics","Gastroenterology and Hepatology","Oncology"]
doi:10.7717/peerj.3385
68 downloads
368 views

Background Synthesis of thyroid hormones and regulation of their metabolism involve free radicals that may affect redox balance in the body. Thyroid disorders causing variations in the levels of thyroid hormones may alter cellular oxidative stress. The aim of this...

["Biochemistry","Molecular Biology","Oncology","Medical Genetics","Metabolic Sciences"]
doi:10.7717/peerj.3365
71 downloads
217 views

Objectives The purpose of this study is to determine the prevalence and clinical impact of human papillomavirus (HPV) related laryngeal squamous cell carcinoma (LSCC). Methods A total of 106 LSCC patients who underwent primary surgical resection with or without...

["Oncology","Otorhinolaryngology","Pathology"]
doi:10.7717/peerj.3395
74 downloads
299 views

Background Several studies report aberrant expression of sine oculis homeobox (SIX) homolog family members during cancer development and progression. SIX4 participates in organ development, such as myogenesis and neurogenesis. However, the expression and clinical...

["Biochemistry","Gastroenterology and Hepatology","Oncology"]
doi:10.7717/peerj.3394
53 downloads
198 views

Objectives Angiopoietins have been found to play essential roles in tumor angiogenesis. The present study was aimed at investigating the diagnostic and prognostic values of serum angiopoietin 1 and 2 (sAng-1 and sAng-2) in cervical cancer. Methods The sAng-1 and...

["Gynecology and Obstetrics","Oncology","Women\u2019s Health"]
doi:10.7717/peerj.3387
1 citation
47 downloads
261 views

Background Pituitary adenoma is one of the most common intracranial neoplasms, and its primary treatment is endoscopic endonasal transsphenoidal tumorectomy. Postoperative hypokalemia in these patients is a common complication, and is associated with morbidity...

["Diabetes and Endocrinology","Epidemiology","Oncology"]
doi:10.7717/peerj.3337
91 downloads
310 views

Background Treatments that target cancer stem cells play an important role in the controlling and eliminating of tumor initiation as well as in development, progression, and chemotherapy/radiotherapy resistance. In our previous study, we cultured and harvested...

["Oncology","Translational Medicine"]
doi:10.7717/peerj.3233
74 downloads
343 views

Background Molecularly targeted therapies improved survival status of some patients with lung adenocarcinoma, which accounts for 40% of all lung cancers, and in-depth study of gene alterations is important for the personalized treatment. Methods The legacy archive...

["Genetics","Oncology","Respiratory Medicine","Medical Genetics"]
doi:10.7717/peerj.3216
63 downloads
281 views

Background Electrolytic ablation and electroporation based ablation are minimally invasive, non-thermal surgical technologies that employ electrical currents and electric fields to ablate undesirable cells in a volume of tissue. In this study, we explore the attributes...

["Bioengineering","Biophysics","Oncology","Pathology","Histology"]
doi:10.7717/peerj.3190

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