Peer-reviewed Articles - Medicine

41 downloads
279 views

Background Disturbances in mineral and bone metabolism represent one of the most complex complications of chronic kidney disease (CKD). Serotonin, a monoamine synthesized from tryptophan, may play a potential role in bone metabolism. Brain-derived serotonin exerts...

["Anatomy and Physiology","Nephrology","Neurology"]
doi:10.7717/peerj.3199
130 downloads
649 views

Background The ergogenic effects of analgesic substances suggest that pain perception is an important regulator of work-rate during fatiguing exercise. Recent research has shown that endogenous inhibitory responses, which act to attenuate nociceptive input and...

["Neuroscience","Anaesthesiology and Pain Management","Neurology","Psychiatry and Psychology"]
doi:10.7717/peerj.3028
70 downloads
246 views

Background Paroxysmal sympathetic hyperactivity (PSH) results and aggravates in secondary brain injury, which seriously affects the prognosis of severe traumatic brain injury patients. Although several studies have focused on the treatment of PSH, few have concentrated...

["Drugs and Devices","Emergency and Critical Care","Neurology"]
doi:10.7717/peerj.2986
87 downloads
380 views

Background Hyperglycemia is a known predictor of negative outcomes in stroke. Several glycemic measures, including admission random glucose, fasting glucose, and glycated hemoglobin (HbA1c), have been associated with bad neurological outcomes in acute ischemic...

["Diabetes and Endocrinology","Neurology"]
doi:10.7717/peerj.2948
60 downloads
292 views

Problem The purpose of this work is to provide some validation methods for evaluating the hemodynamic assessment of Cerebral Arteriovenous Malformation (CAVM). This article emphasizes the importance of validating noninvasive measurements for CAVM patients, which...

["Neurology","Radiology and Medical Imaging"]
doi:10.7717/peerj.2724
133 downloads
405 views

Mild traumatic brain injury typically involves temporary impairment of neurological function. Previous studies used water pressure or rotational injury for designing the device to make a rat a mild traumatic brain injury model. The objective of this study was to...

["Neuroscience","Neurology"]
doi:10.7717/peerj.2818
1 citation
152 downloads
458 views

Background The involvement of multiple genes and missing heritability, which are dominant in complex diseases such as multiple sclerosis (MS), entail using network biology to better elucidate their molecular basis and genetic factors. We therefore aimed to integrate...

["Bioinformatics","Computational Biology","Immunology","Neurology"]
doi:10.7717/peerj.2775
147 downloads
545 views

Brain perfusion is of key importance to assess brain function. Modern CT scanners can acquire perfusion maps of the cerebral parenchyma in vivo at submillimeter resolution. These perfusion maps give insights into the hemodynamics of the cerebral parenchyma and...

["Radiology and Medical Imaging","Neurology","Computational Science"]
doi:10.7717/peerj.2683
128 downloads
384 views

A small molecule named ISRIB has recently been described to enhance memory in rodents. In this study we aimed to test whether ISRIB would reverse learning and memory deficits in the J20 mouse model of human amyloid precursor protein (hAPP) overexpression, a model...

["Animal Behavior","Neuroscience","Cognitive Disorders","Neurology","Translational Medicine"]
doi:10.7717/peerj.2565
119 downloads
591 views

Background Although increased nasality can originate from basal ganglia dysfunction, data regarding hypernasality in Parkinson’s disease (PD) and Huntington’s disease (HD) are very sparse. The aim of the current study was to analyze acoustic and perceptual correlates...

["Neuroscience","Neurology","Otorhinolaryngology","Computational Science","Coupled Natural and Human Systems"]
doi:10.7717/peerj.2530
282 downloads
686 views

Background Individuals with mental illness often experience stigmatization and encounter stereotypes such as being dangerous or unpredictable. To further improve measures against psychiatric stigma, it is of importance to understand its components. In this study,...

["Neurology","Psychiatry and Psychology"]
doi:10.7717/peerj.2360
94 downloads
736 views

The present study investigated the effects of grip on changes in the median nerve cross-sectional area (MNCSA) and median nerve diameter in the radial-ulnar direction (D1) and dorsal-palmar direction (D2) at three wrist angles. Twenty-nine healthy participants...

["Kinesiology","Neurology","Orthopedics"]
doi:10.7717/peerj.2510
164 downloads
429 views

Background Magnetic resonance imaging (MRI) is the best biomarker of inflammatory disease activity in relapsing remitting Multiple Sclerosis (RRMS) so far but the association with disability is weak. Appearance of new MRI-lesions is used to evaluate response to...

["Neurology","Psychiatry and Psychology","Radiology and Medical Imaging","Statistics"]
doi:10.7717/peerj.2442
130 downloads
497 views

Objective The autonomy of individuals is linked to the achievement of instrumental activities of daily living that require complex behavior. In the elderly, the assessment of autonomy is usually based on questionnaires that have strong subjective constraints. Considering...

["Neurology","Psychiatry and Psychology"]
doi:10.7717/peerj.2351
196 downloads
581 views

8-Hydroxyquinoline and derivatives exhibit multifunctional properties, including antioxidant, antineurodegenerative, anticancer, anti-inflammatory and antidiabetic activities. In biological systems, elevation of intracellular calcium can cause calpain activation,...

["Neuroscience","Evidence Based Medicine","Neurology"]
doi:10.7717/peerj.2389

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