Peer-reviewed Articles - Medicine

107 downloads
277 views

Background Osteoprotegerin (OPG) is a potential biomarker for severity and complications of cardiovascular diseases. Peripheral arterial disease (PAD) is associated with an increased risk of death in kidney transplantation (KT) patients. This prospective cross-sectional...

["Nephrology","Surgery and Surgical Specialties"]
doi:10.7717/peerj.3847
46 downloads
329 views

Background Frailty exhibits a high prevalence in end-stage renal disease (ESRD) patients and is associated with adverse health-related outcomes, including falls and fractures. Available studies do not address whether frailty is associated with temporal changes...

["Geriatrics","Nephrology","Palliative Care"]
doi:10.7717/peerj.3542
85 downloads
494 views

Background Renal supportive care (RSC) is an important option for elderly individuals reaching end-stage renal disease; however, the frequency of RSC practice is very low among Asian countries. We evaluated the attitude, the knowledge, and the preference for specific...

["Geriatrics","Nephrology","Public Health","Palliative Care"]
doi:10.7717/peerj.3540
96 downloads
282 views

Objective To compare the risk of postoperative ureteral stricture formation following retroperitoneal laparoscopic ureterolithotomy (RPLU) and ureteroscopy with holmium: YAG laser lithotripsy (URSL) in patients with proximal ureteral stones. Materials and Methods...

["Nephrology","Surgery and Surgical Specialties","Urology"]
doi:10.7717/peerj.3483
1 citation
306 downloads
685 views

Aim To evaluate the effects of sodium-glucose co-transporter 2 (SGLT2) inhibition on renal function and albuminuria in patients with type 2 diabetes. Methods We conducted systematic searches of PubMed, Embase and Cochrane Central Register of Controlled Trials up...

["Diabetes and Endocrinology","Evidence Based Medicine","Nephrology"]
doi:10.7717/peerj.3405
235 downloads
599 views

Background The kidney is always subjected to high metabolic demand. The aim of this study was to characterize metabolic profiles of a rat model of chronic kidney disease (CKD) with cardiorenal syndrome (CRS) induced by prolonged hypertension. Methods We used inbred...

["Molecular Biology","Cardiology","Nephrology"]
doi:10.7717/peerj.3352
1 citation
162 downloads
774 views

Background Disturbances in mineral and bone metabolism represent one of the most complex complications of chronic kidney disease (CKD). Serotonin, a monoamine synthesized from tryptophan, may play a potential role in bone metabolism. Brain-derived serotonin exerts...

["Anatomy and Physiology","Nephrology","Neurology"]
doi:10.7717/peerj.3199
450 downloads
653 views

Background Although the relationship between a history of kidney stones and chronic kidney disease (CKD) has been explored in many studies, it is still far from being well understood. Thus, we conducted a meta-analysis of studies comparing rates of CKD in patients...

["Epidemiology","Nephrology","Urology"]
doi:10.7717/peerj.2907
3 citations
205 downloads
628 views

Testosterone has been reported to cause blood pressure to increase. However mechanisms that underlie the effect of this hormone on this physiological parameter are currently not well understood. The aims of this study were to investigate effects of testosterone...

["Molecular Biology","Nephrology","Pharmacology"]
doi:10.7717/peerj.2145
1 citation
258 downloads
717 views

Background. Geriatric syndromes (GS) exhibit high prevalence in patients with end-stage renal disease (ESRD) under chronic dialysis irrespective of age. We sought to determine whether GS influences medication adherence in ESRD patients. Methods. A prospective cohort...

["Evidence Based Medicine","Geriatrics","Hematology","Nephrology","Palliative Care"]
doi:10.7717/peerj.2122
1 citation
205 downloads
1,042 views

Background. Several factors have been validated as predictors of disease recurrence in upper tract urothelial carcinoma. However, the oncological outcomes between different surgical approaches (open nephroureterectomy versus laparoscopic nephroureterectomy, ONU...

["Nephrology","Surgery and Surgical Specialties","Urology"]
doi:10.7717/peerj.2063
335 downloads
940 views

Background: Chronic kidney disease (CKD) is a condition associated with progressive loss of kidney function and kidney damage. The two common causes of CKD are diabetes mellitus and hypertension. Other causes of CKD also include polycystic kidney disease, obstructive...

["Diabetes and Endocrinology","Nephrology","Medical Genetics"]
doi:10.7717/peerj.1908
8 citations
411 downloads
1,224 views

It is unknown whether autophagy activity is altered in insulin resistant podocytes and whether autophagy could be a therapeutic target for diabetic nephropathy (DN). Here we used shRNA transfection to knockdown the insulin receptor (IR) gene in cultured human immortalized...

["Cell Biology","Nephrology"]
doi:10.7717/peerj.1888
1 citation
357 downloads
811 views

Serum uric acid (SUA) level has been proposed to have important connections with chronic kidney disease (CKD), while the impact of SUA level on the natural history of glomerular filtration rate (GFR) decline remains unknown. The present study aims to study the...

["Epidemiology","Nephrology"]
doi:10.7717/peerj.1859
6 citations
662 downloads
1,273 views

Background. Patients with end-stage renal disease (ESRD) have a high symptom burden, among which fatigue is highly prevalent. Many fatigue-assessing instruments exist, but comparisons among instruments in this patient population have yet to be investigated. Methods....

["Evidence Based Medicine","Geriatrics","Nephrology","Palliative Care"]
doi:10.7717/peerj.1818

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