Peer-reviewed Articles - Medicine

37 downloads
241 views

Background Frailty exhibits a high prevalence in end-stage renal disease (ESRD) patients and is associated with adverse health-related outcomes, including falls and fractures. Available studies do not address whether frailty is associated with temporal changes...

["Geriatrics","Nephrology","Palliative Care"]
doi:10.7717/peerj.3542
66 downloads
394 views

Background Renal supportive care (RSC) is an important option for elderly individuals reaching end-stage renal disease; however, the frequency of RSC practice is very low among Asian countries. We evaluated the attitude, the knowledge, and the preference for specific...

["Geriatrics","Nephrology","Public Health","Palliative Care"]
doi:10.7717/peerj.3540
59 downloads
192 views

Objective To compare the risk of postoperative ureteral stricture formation following retroperitoneal laparoscopic ureterolithotomy (RPLU) and ureteroscopy with holmium: YAG laser lithotripsy (URSL) in patients with proximal ureteral stones. Materials and Methods...

["Nephrology","Surgery and Surgical Specialties","Urology"]
doi:10.7717/peerj.3483
209 downloads
464 views

Aim To evaluate the effects of sodium-glucose co-transporter 2 (SGLT2) inhibition on renal function and albuminuria in patients with type 2 diabetes. Methods We conducted systematic searches of PubMed, Embase and Cochrane Central Register of Controlled Trials up...

["Diabetes and Endocrinology","Evidence Based Medicine","Nephrology"]
doi:10.7717/peerj.3405
162 downloads
452 views

Background The kidney is always subjected to high metabolic demand. The aim of this study was to characterize metabolic profiles of a rat model of chronic kidney disease (CKD) with cardiorenal syndrome (CRS) induced by prolonged hypertension. Methods We used inbred...

["Molecular Biology","Cardiology","Nephrology"]
doi:10.7717/peerj.3352
117 downloads
651 views

Background Disturbances in mineral and bone metabolism represent one of the most complex complications of chronic kidney disease (CKD). Serotonin, a monoamine synthesized from tryptophan, may play a potential role in bone metabolism. Brain-derived serotonin exerts...

["Anatomy and Physiology","Nephrology","Neurology"]
doi:10.7717/peerj.3199
348 downloads
557 views

Background Although the relationship between a history of kidney stones and chronic kidney disease (CKD) has been explored in many studies, it is still far from being well understood. Thus, we conducted a meta-analysis of studies comparing rates of CKD in patients...

["Epidemiology","Nephrology","Urology"]
doi:10.7717/peerj.2907
3 citations
183 downloads
585 views

Testosterone has been reported to cause blood pressure to increase. However mechanisms that underlie the effect of this hormone on this physiological parameter are currently not well understood. The aims of this study were to investigate effects of testosterone...

["Molecular Biology","Nephrology","Pharmacology"]
doi:10.7717/peerj.2145
1 citation
237 downloads
677 views

Background. Geriatric syndromes (GS) exhibit high prevalence in patients with end-stage renal disease (ESRD) under chronic dialysis irrespective of age. We sought to determine whether GS influences medication adherence in ESRD patients. Methods. A prospective cohort...

["Evidence Based Medicine","Geriatrics","Hematology","Nephrology","Palliative Care"]
doi:10.7717/peerj.2122
190 downloads
944 views

Background. Several factors have been validated as predictors of disease recurrence in upper tract urothelial carcinoma. However, the oncological outcomes between different surgical approaches (open nephroureterectomy versus laparoscopic nephroureterectomy, ONU...

["Nephrology","Surgery and Surgical Specialties","Urology"]
doi:10.7717/peerj.2063
319 downloads
835 views

Background: Chronic kidney disease (CKD) is a condition associated with progressive loss of kidney function and kidney damage. The two common causes of CKD are diabetes mellitus and hypertension. Other causes of CKD also include polycystic kidney disease, obstructive...

["Diabetes and Endocrinology","Nephrology","Medical Genetics"]
doi:10.7717/peerj.1908
8 citations
383 downloads
1,106 views

It is unknown whether autophagy activity is altered in insulin resistant podocytes and whether autophagy could be a therapeutic target for diabetic nephropathy (DN). Here we used shRNA transfection to knockdown the insulin receptor (IR) gene in cultured human immortalized...

["Cell Biology","Nephrology"]
doi:10.7717/peerj.1888
1 citation
343 downloads
737 views

Serum uric acid (SUA) level has been proposed to have important connections with chronic kidney disease (CKD), while the impact of SUA level on the natural history of glomerular filtration rate (GFR) decline remains unknown. The present study aims to study the...

["Epidemiology","Nephrology"]
doi:10.7717/peerj.1859
6 citations
577 downloads
1,165 views

Background. Patients with end-stage renal disease (ESRD) have a high symptom burden, among which fatigue is highly prevalent. Many fatigue-assessing instruments exist, but comparisons among instruments in this patient population have yet to be investigated. Methods....

["Evidence Based Medicine","Geriatrics","Nephrology","Palliative Care"]
doi:10.7717/peerj.1818
2 citations
316 downloads
1,050 views

MicroRNAs (miRNAs) are negative regulators of gene expression and protein abundance. Current evidence shows an association of miRNAs with acute kidney injury (AKI) leading to substantially increased morbidity and mortality. Here, we investigated whether miRNAs...

["Cell Biology","Nephrology","Pathology"]
doi:10.7717/peerj.1729

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