Peer-reviewed Articles - Medicine

159 downloads
534 views

Identification of appropriate reference genes (RGs) is critical to accurate data interpretation in quantitative real-time PCR (qPCR) experiments. In this study, we have utilised next generation RNA sequencing (RNA-seq) to analyse the transcriptome of a panel of...

["Genomics","Molecular Biology","Dermatology","Oncology","Medical Genetics"]
doi:10.7717/peerj.3631
64 downloads
332 views

The prevalence of Type II Diabetes (T2D) has been increasing and has become a disease of significant public health burden in Jordan. None of the previous genome-wide association studies (GWAS) have specifically investigated the Middle East populations. The Circassian...

["Genetics","Genomics","Diabetes and Endocrinology","Medical Genetics"]
doi:10.7717/peerj.3618
1 citation
100 downloads
453 views

Background Synthesis of thyroid hormones and regulation of their metabolism involve free radicals that may affect redox balance in the body. Thyroid disorders causing variations in the levels of thyroid hormones may alter cellular oxidative stress. The aim of this...

["Biochemistry","Molecular Biology","Oncology","Medical Genetics","Metabolic Sciences"]
doi:10.7717/peerj.3365
116 downloads
425 views

Background Molecularly targeted therapies improved survival status of some patients with lung adenocarcinoma, which accounts for 40% of all lung cancers, and in-depth study of gene alterations is important for the personalized treatment. Methods The legacy archive...

["Genetics","Oncology","Respiratory Medicine","Medical Genetics"]
doi:10.7717/peerj.3216
160 downloads
607 views

Although numbers of cancer cell lines have been shown to be successfully reprogrammed into induced pluripotent stem cells (iPSCs), reprogramming Oral Squamous Cell Carcinoma (OSCC) to pluripotency in relation to its cancer cell type and the expression pattern of...

["Cell Biology","Molecular Biology","Oncology","Medical Genetics"]
doi:10.7717/peerj.3174
343 downloads
1,466 views

The past two decades have brought many important advances in our understanding of the hereditary susceptibility to cancer. Numerous studies have provided convincing evidence that identification of germline mutations associated with hereditary cancer syndromes can...

["Genomics","Oncology","Medical Genetics"]
doi:10.7717/peerj.3046
101 downloads
366 views

Previous studies have investigated the association between cytotoxic T-lymphocyte antigen-4 (CTLA-4) polymorphisms and breast cancer susceptibility, but the results remained inconsistent. Therefore, we evaluated the relationship between four common CTLA-4 polymorphisms...

["Evidence Based Medicine","Oncology","Medical Genetics"]
doi:10.7717/peerj.2815
210 downloads
628 views

Background Several genes and their single nucleotide polymorphisms (SNPs) are associated with either spontaneous resolution of hepatitis C infection or better treatment-induced viral clearance. We tested a cohort of intravenous drug users (IVDU) diagnosed with...

["Gastroenterology and Hepatology","Immunology","Infectious Diseases","Medical Genetics"]
doi:10.7717/peerj.2576
8 citations
458 downloads
1,344 views

Background. Fetal malformations and other structural abnormalities are relatively frequent findings in the course of routine prenatal ultrasonographic examination. Due to their considerable genetic and clinical heterogeneity, the underlying genetic cause is often...

["Genetics","Genomics","Medical Genetics"]
doi:10.7717/peerj.1955
318 downloads
832 views

Background: Chronic kidney disease (CKD) is a condition associated with progressive loss of kidney function and kidney damage. The two common causes of CKD are diabetes mellitus and hypertension. Other causes of CKD also include polycystic kidney disease, obstructive...

["Diabetes and Endocrinology","Nephrology","Medical Genetics"]
doi:10.7717/peerj.1908
2 citations
185 downloads
958 views

Crohn’s disease (CD) is a prominent type of inflammatory bowel disease (IBD) that can affect any part of the gastrointestinal tract. CD is known to have higher prevalence in the Western countries, but the number of cases has been increasing in the past decades...

["Genetics","Molecular Biology","Gastroenterology and Hepatology","Medical Genetics"]
doi:10.7717/peerj.1843
2 citations
193 downloads
773 views

Background. Prostate cancer makes up approximately 15% of all cancers diagnosed in men in developed nations and approximately 4% of cases in developing nations. Although it is clear that prostate cancer has a genetic component and single nucleotide polymorphisms...

["Oncology","Urology","Medical Genetics"]
doi:10.7717/peerj.1731
177 downloads
612 views

In January 2012, a review of the cases of chromosome 15q24 microdeletion syndrome was published. However, this study did not include inferential statistics. The aims of the present study were to update the literature search and calculate confidence intervals for...

["Epidemiology","Statistics","Medical genetics"]
doi:10.7717/peerj.1641
1 citation
320 downloads
845 views

Anxiety disorders (ADs) are disabling chronic disorders with exaggerated behavioral response to threats. This study was aimed at testing the hypothesis that ADs may be associated with reduced neurotrophic activity, particularly of Brain-derived neurotrophic factor...

["Genomics","Neuroscience","Global Health","Psychiatry and Psychology","Medical Genetics"]
doi:10.7717/peerj.1252
1 citation
156 downloads
649 views

Aims. Epistasis from gene set based on the function-related genes may confer to the susceptibility of type 2 diabetes (T2D). The Wnt pathway has been reported to play an important role in the pathogenesis of T2D. Here we applied tag SNPs to explore the association...

["Genetics","Genomics","Diabetes and Endocrinology","Medical Genetics"]
doi:10.7717/peerj.1304

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