Peer-reviewed Articles - Medicine

Background Pertussis is a vaccine-preventable disease, yet an increasing incidence of pertussis occurs in many countries. Thailand has a long-standing pertussis vaccination policy, therefore most expectant mothers today had received vaccines as children. The resurgence...

["Immunology","Infectious Diseases","Women\u2019s Health"]
doi:10.7717/peerj.4043
37 downloads
392 views

Cancers have killed millions of people in human history and are still posing a serious health problem worldwide. Therefore, there is an urgent need for developing preventive and therapeutic cancer vaccines. Among various cancer vaccine development platforms, virus-like...

["Immunology","Pharmacology"]
doi:10.7717/peerj.4053
73 downloads
388 views

Background The aim of this cross-sectional study was to identify important biopsychosocial correlates of major depression. Biological mechanisms, including the inflammatory and the tryptophan-serotonin deficiency hypotheses of major depression, were investigated...

["Immunology","Psychiatry and Psychology"]
doi:10.7717/peerj.3968
60 downloads
292 views

Tumor-infiltrating lymphocytes (TILs) are associated with better clinical outcomes in many tumors. TILs represent a cell-mediated immune response against the carcinoma. CD8+ TILs are a crucial component of cell-mediated immunity. The significance of CD8+ TILs has...

["Immunology","Oncology","Urology"]
doi:10.7717/peerj.3921
55 downloads
314 views

The cane toad (Rhinella marina) has undergone rapid evolution during its invasion of tropical Australia. Toads from invasion front populations (in Western Australia) have been reported to exhibit a stronger baseline phagocytic immune response than do conspecifics...

["Ecology","Evolutionary Studies","Zoology","Immunology"]
doi:10.7717/peerj.3856
68 downloads
357 views

Objective The objective of this study is to conduct a systematic review of multi-scale HIV immunoepidemiological models to improve our understanding of the synergistic impact between the HIV viral-immune dynamics at the individual level and HIV transmission dynamics...

["Computational Biology","Mathematical Biology","Epidemiology","HIV","Immunology"]
doi:10.7717/peerj.3877
110 downloads
448 views

Nodaviruses are small bipartite RNA viruses which belong to the family of Nodaviridae. They are categorized into alpha-nodavirus, which infects insects, and beta-nodavirus, which infects fishes. Another distinct group of nodavirus infects shrimps and prawns, which...

["Aquaculture, Fisheries and Fish Science","Virology","Immunology"]
doi:10.7717/peerj.3841
61 downloads
337 views

Cytokines are fundamental for a functioning immune system, and thus potentially serve as important indicators of animal health. Quantitation of mRNA using quantitative reverse transcription polymerase chain reaction (qRT-PCR) is an established immunological technique....

["Marine Biology","Molecular Biology","Veterinary Medicine","Immunology"]
doi:10.7717/peerj.3840
150 downloads
546 views

Background Dengue viral infection is an acute infection that has the potential to have severe complications as its major sequela. Currently, there is no routine laboratory biomarker with which to predict the severity of dengue infection or monitor the effectiveness...

["Microbiology","Virology","Epidemiology","Immunology","Infectious Diseases"]
doi:10.7717/peerj.3589
97 downloads
492 views

Background A well-functioning immune defence is crucial for fitness, but our knowledge about the immune system and its complex interactions is still limited. Major histocompatibility complex (MHC) molecules are involved in T-cell mediated adaptive immune responses,...

["Evolutionary Studies","Molecular Biology","Zoology","Immunology"]
doi:10.7717/peerj.3679
100 downloads
516 views

The cynomolgus macaque (Macaca fascicularis) is an extensively utilised nonhuman primate model for biomedical research due to its biological, behavioural, and genetic similarities to humans. Genomic information of cynomolgus macaque is vital for research in various...

["Bioinformatics","Genomics","Zoology","Immunology"]
doi:10.7717/peerj.3566
71 downloads
432 views

Background 2′–4′ Dinitrofluorobenzene (DNFB) induced contact hypersensitivity is an established model of contact sensitivity and leukocyte migration. Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1) deficient mice were used to examine the role of PECAM-1...

["Cell Biology","Dermatology","Immunology"]
doi:10.7717/peerj.3555
2 citations
109 downloads
614 views

Background Oxytetracycline (OTC), which is largely employed in zootechnical and veterinary practices to ensure wellness of farmed animals, is partially absorbed within the gastrointestinal tract depositing in several tissues. Therefore, the potential OTC toxicity...

["Cell Biology","Allergy and Clinical Immunology","Drugs and Devices","Immunology","Pharmacology"]
doi:10.7717/peerj.3236
1 citation
160 downloads
599 views

Apoptosis of lymphocytes is associated with immunosuppression and poor prognosis in sepsis. Our previous report showed that histones, nuclear proteins released from damaged or dying cells in sepsis, can mediate lymphocyte apoptosis via mitochondria damage. Grape...

["Cell Biology","Immunology","Pharmacology"]
doi:10.7717/peerj.3108
1 citation
107 downloads
619 views

Interstitial lung disease (ILD) is a severe extra-articular manifestation of rheumatoid arthritis (RA) that is well-defined as a chronic systemic autoimmune disease. A proportion of patients with RA-associated ILD (RA-ILD) develop pulmonary fibrosis (PF), resulting...

["Immunology","Respiratory Medicine","Rheumatology","Statistics"]
doi:10.7717/peerj.3021

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