Peer-reviewed Articles - Medicine

53 downloads
245 views

Background Dengue viral infection is an acute infection that has the potential to have severe complications as its major sequela. Currently, there is no routine laboratory biomarker with which to predict the severity of dengue infection or monitor the effectiveness...

["Microbiology","Virology","Epidemiology","Immunology","Infectious Diseases"]
doi:10.7717/peerj.3589
61 downloads
346 views

Background A well-functioning immune defence is crucial for fitness, but our knowledge about the immune system and its complex interactions is still limited. Major histocompatibility complex (MHC) molecules are involved in T-cell mediated adaptive immune responses,...

["Evolutionary Studies","Molecular Biology","Zoology","Immunology"]
doi:10.7717/peerj.3679
70 downloads
349 views

The cynomolgus macaque (Macaca fascicularis) is an extensively utilised nonhuman primate model for biomedical research due to its biological, behavioural, and genetic similarities to humans. Genomic information of cynomolgus macaque is vital for research in various...

["Bioinformatics","Genomics","Zoology","Immunology"]
doi:10.7717/peerj.3566
56 downloads
368 views

Background 2′–4′ Dinitrofluorobenzene (DNFB) induced contact hypersensitivity is an established model of contact sensitivity and leukocyte migration. Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1) deficient mice were used to examine the role of PECAM-1...

["Cell Biology","Dermatology","Immunology"]
doi:10.7717/peerj.3555
85 downloads
537 views

Background Oxytetracycline (OTC), which is largely employed in zootechnical and veterinary practices to ensure wellness of farmed animals, is partially absorbed within the gastrointestinal tract depositing in several tissues. Therefore, the potential OTC toxicity...

["Cell Biology","Allergy and Clinical Immunology","Drugs and Devices","Immunology","Pharmacology"]
doi:10.7717/peerj.3236
1 citation
122 downloads
504 views

Apoptosis of lymphocytes is associated with immunosuppression and poor prognosis in sepsis. Our previous report showed that histones, nuclear proteins released from damaged or dying cells in sepsis, can mediate lymphocyte apoptosis via mitochondria damage. Grape...

["Cell Biology","Immunology","Pharmacology"]
doi:10.7717/peerj.3108
94 downloads
555 views

Interstitial lung disease (ILD) is a severe extra-articular manifestation of rheumatoid arthritis (RA) that is well-defined as a chronic systemic autoimmune disease. A proportion of patients with RA-associated ILD (RA-ILD) develop pulmonary fibrosis (PF), resulting...

["Immunology","Respiratory Medicine","Rheumatology","Statistics"]
doi:10.7717/peerj.3021
1 citation
185 downloads
709 views

Background Interleukin (IL)-17 produced by mainly T helper 17 (Th17) cells may play an important destructive role in chronic periodontitis (CP). Thus, anti-inflammatory cytokines, such as IL-35, might have a beneficial effect in periodontitis by inhibiting differentiation...

["Dentistry","Immunology"]
doi:10.7717/peerj.2999
111 downloads
484 views

Genetic diversity is one of the pillars of conservation biology research. High genetic diversity and abundant genetic variation in an organism may be suggestive of capacity to adapt to various environmental changes. The major histocompatibility complex (MHC) is...

["Biodiversity","Conservation Biology","Genetics","Zoology","Immunology"]
doi:10.7717/peerj.2917
4 citations
106 downloads
524 views

Snakebite envenomings represent a neglected public health issue in many parts of the rural tropical world. Animal-derived antivenoms have existed for more than a hundred years and are effective in neutralizing snake venom toxins when timely administered. However,...

["Bioinformatics","Biotechnology","Toxicology","Immunology","Synthetic Biology"]
doi:10.7717/peerj.2924
98 downloads
323 views

Background Malaria elimination campaigns are planned or active in many countries. The effects of malaria elimination on immune responses such as antigen-specific IFN- γ responses are not well characterized. Methods IFN- γ responses to the P. falciparum antigens...

["Immunology","Infectious Diseases"]
doi:10.7717/peerj.2855
2 citations
235 downloads
626 views

Background The involvement of multiple genes and missing heritability, which are dominant in complex diseases such as multiple sclerosis (MS), entail using network biology to better elucidate their molecular basis and genetic factors. We therefore aimed to integrate...

["Bioinformatics","Computational Biology","Immunology","Neurology"]
doi:10.7717/peerj.2775
2 citations
168 downloads
626 views

Background T cells play a pivotal role in the adaptive immunity that participates in a wide range of immune responses through a complicated cytokine network. Imbalance of T-cell responses is involved in several immune disorders. Neolitsea species, one of the biggest...

["Cell Biology","Food Science and Technology","Immunology","Pharmacology"]
doi:10.7717/peerj.2758
177 downloads
571 views

Streptococcus pneumoniae is a pathogen that causes serious invasive infections, such as septicemia, meningitis and pneumonia in addition to mild upper respiratory tract infections. Protection from pneumococcal diseases is thought to be mediated mainly by serotype-specific...

["Immunology","Infectious Diseases"]
doi:10.7717/peerj.2737
1 citation
86 downloads
543 views

Ficolins can activate the lectin pathway of the complement system that provides innate immune protection against pathogens, marks host cellular debris for clearance, and promotes inflammation. Baseline inflammation increases with aging in a phenomenon known as...

["Immunology","Translational Medicine"]
doi:10.7717/peerj.2705

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