Peer-reviewed Articles - Medicine

76 downloads
398 views

Background Leukocyte concentrations follow a circadian pattern in mammals, with elevated values at times of potential contact with pathogens and parasites. We hypothesized that this pattern is disturbed after an immune challenge. Methods In Thailand, we captured...

["Animal Behavior","Ecology","Veterinary Medicine","Zoology","Hematology"]
doi:10.7717/peerj.3570
87 downloads
393 views

Development of drug resistance limits the effectiveness of anticancer treatments. Understanding the molecular mechanisms triggering this event in tumor cells may lead to improved therapeutic strategies. Here we used RNA-seq to compare the transcriptomes of a murine...

["Molecular Biology","Hematology"]
doi:10.7717/peerj.3432
126 downloads
417 views

Aim To investigate the association of C-MYC protein expression and risk stratification in mantle cell lymphoma (MCL), and to evaluate the utility of C-MYC protein as a prognostic biomarker in clinical practice. Methods We conducted immunohistochemical staining...

["Hematology","Oncology"]
doi:10.7717/peerj.3457
1 citation
166 downloads
494 views

Background ABO blood group is a hereditary factor of plasma levels of coagulation factor VIII (FVIII) and von Willebrand factor (VWF). Age and gender have been shown to influence FVIII, VWF, fibrinogen (Fbg), and ADAMTS13 (A disintegrin and metalloprotease with...

["Biochemistry","Global Health","Hematology","Translational Medicine"]
doi:10.7717/peerj.3156
108 downloads
586 views

Background Preanalytic factors such as time and temperature can have significant effects on laboratory test results. For example, ammonium concentration will increase 31% in blood samples stored at room temperature for 30 min before centrifugation. To reduce preanalytic...

["Biochemistry","Veterinary Medicine","Emergency and Critical Care","Gastroenterology and Hepatology","Hematology"]
doi:10.7717/peerj.2732
1 citation
155 downloads
539 views

This study compares and evaluates the prediction of hepatitis in Guangxi Province, China by using back propagation neural networks based genetic algorithm (BPNN-GA), generalized regression neural networks (GRNN), and wavelet neural networks (WNN). In order to compare...

["Epidemiology","Hematology","Infectious Diseases","Computational Science"]
doi:10.7717/peerj.2684
1,027 downloads
819 views

Background Laparoscopic cholecystectomies (LC) are generally performed in a 12 mmHg-pressured pneumoperitoneum in a slight sitting position. Considerable thromboembolism risk arises in this operation due to pneumoperitoneum, operation position and risk factors...

["Anaesthesiology and Pain Management","Gastroenterology and Hepatology","Hematology","Surgery and Surgical Specialties"]
doi:10.7717/peerj.2375
1 citation
319 downloads
1,077 views

Despite the promise of hematological parameters and blood chemistry in monitoring the health of marine fishes, baseline data is often lacking for small fishes that comprise central roles in marine food webs. This study establishes blood chemistry and hematological...

["Aquaculture, Fisheries and Fish Science","Bioinformatics","Marine Biology","Veterinary Medicine","Hematology"]
doi:10.7717/peerj.2262
145 downloads
577 views

Background. A “cafeteria” diet is a self-selected high-fat diet, providing an excess of energy, which can induce obesity. Excess of lipids in the diet hampers glucose utilization eliciting insulin resistance, which, further limits amino acid oxidation for energy....

["Anatomy and Physiology","Diabetes and Endocrinology","Hematology","Nutrition","Metabolic Sciences"]
doi:10.7717/peerj.2302
1 citation
229 downloads
944 views

Objective. Bone lesion is crucial for diagnosing and management of polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin change (POEMS) syndrome, a rare plasma cell disorder. This study is to compare the effectiveness of X-ray skeletal survey...

["Hematology","Orthopedics","Radiology and Medical Imaging"]
doi:10.7717/peerj.2294
1 citation
237 downloads
677 views

Background. Geriatric syndromes (GS) exhibit high prevalence in patients with end-stage renal disease (ESRD) under chronic dialysis irrespective of age. We sought to determine whether GS influences medication adherence in ESRD patients. Methods. A prospective cohort...

["Evidence Based Medicine","Geriatrics","Hematology","Nephrology","Palliative Care"]
doi:10.7717/peerj.2122
268 downloads
877 views

We previously reported that the inflammasome inhibitor cucurbitacin D (CuD) induces apoptosis in human leukemia cell lines. Here, we investigated the effects of CuD and a B-cell lymphoma extra-large (Bcl-xL) inhibitor on autophagy in peripheral blood lymphocytes...

["Cell Biology","Drugs and Devices","Hematology","Oncology"]
doi:10.7717/peerj.2026
2 citations
641 downloads
913 views

Background: Food insecurity and hidden hunger (micronutrient deficiency) affect about two billion people globally. Household food insecurity (HFI) has been shown to be associated with one or multiple micronutrient (MMN) deficiencies among women and children. Chronic...

["Hematology","Nutrition","Public Health","Women\u2019s Health"]
doi:10.7717/peerj.1945
285 downloads
1,168 views

Background. Hemophilia is a rare recessive X-linked disease characterized by a deficiency of coagulation factor VIII or factor IX. Its current treatment is merely palliative. Advanced therapies are likely to become the treatment of choice for the disease as they...

["Biotechnology","Molecular Biology","Hematology","Pharmacology"]
doi:10.7717/peerj.1907
1 citation
189 downloads
952 views

Cytochrome P450 (CYP) epoxygenases and the metabolites epoxyeicosatrienoic acids (EETs) exert multiple biological effects in various malignancies. We have previously found EETs to be secreted by multiple myeloma (MM) cells and to be involved in MM angiogenesis,...

["Cell Biology","Hematology"]
doi:10.7717/peerj.1925

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