Peer-reviewed Articles - Medicine

41 downloads
219 views

Evaluation of depth of anaesthesia (DoA) is critical in clinical surgery. Indices derived from electroencephalogram (EEG) are currently widely used to quantify DoA. However, there are known to be inaccurate under certain conditions; therefore, experienced anaesthesiologists...

["Anaesthesiology and Pain Management","Statistics","Computational Science"]
doi:10.7717/peerj.4067
71 downloads
330 views

The role of glial cells in pain modulation has recently gathered attention. The objective of this study was to determine healthy spinal microglia and astrocyte morphology and disposition in equine spinal cord dorsal horns using Iba-1 and GFAP/Cx-43 immunofluorescence...

["Molecular Biology","Neuroscience","Veterinary Medicine","Anaesthesiology and Pain Management"]
doi:10.7717/peerj.3965
1 citation
83 downloads
360 views

Background Respondent fatigue, also known as survey fatigue, is a common problem in the collection of survey data. Factors that are known to influence respondent fatigue include survey length, survey topic, question complexity, and open-ended question type. There...

["Anaesthesiology and Pain Management","Global Health","Statistics","Human\u2013Computer Interaction"]
doi:10.7717/peerj.3785
1 citation
124 downloads
699 views

Background New-onset atrial fibrillation (AF) is the most common arrhythmia in critically ill patients. Although evidence base and expert consensus opinion for management have been summarised in several international guidelines, no specific considerations for critically...

["Anaesthesiology and Pain Management","Cardiology","Emergency and Critical Care"]
doi:10.7717/peerj.3716
49 downloads
264 views

Background Because etomidate induces prolonged adrenal suppression, even following a single bolus, its use as an infused anesthetic is limited. Our previous study indicated that a single administration of the novel etomidate analog methoxyethyletomidate hydrochloride...

["Animal Behavior","Neuroscience","Veterinary Medicine","Anaesthesiology and Pain Management"]
doi:10.7717/peerj.3693
59 downloads
336 views

Background Hypoxia-inducible factor (HIF)-1 is involved in the regulation of hypoxic preconditioning in cardiomyocytes. Under hypoxic conditions, HIF-1α accumulates and is translocated to the nucleus, where it forms an active complex with HIF-1β and activates transcription...

["Cell Biology","Anaesthesiology and Pain Management","Cardiology"]
doi:10.7717/peerj.3662
153 downloads
1,144 views

Background Previous studies in human patients suggest depth of sedation may be affected by environmental noise or music; however, related data in domestic animals is limited. The objective of the current study was to investigate the effect of noise and music on...

["Animal Behavior","Veterinary Medicine","Anaesthesiology and Pain Management"]
doi:10.7717/peerj.3659
119 downloads
486 views

Background Deliberate hypotension is one way to achieve a bloodless surgical field in endoscopic sinus surgery (ESS). We compared two anaesthesia regimens to induce deliberate hypotension and attempted to determine the most efficient one. Methods Fifty-nine patients...

["Anaesthesiology and Pain Management","Clinical Trials","Otorhinolaryngology","Surgery and Surgical Specialties"]
doi:10.7717/peerj.3370
1 citation
347 downloads
1,115 views

Background The ergogenic effects of analgesic substances suggest that pain perception is an important regulator of work-rate during fatiguing exercise. Recent research has shown that endogenous inhibitory responses, which act to attenuate nociceptive input and...

["Neuroscience","Anaesthesiology and Pain Management","Neurology","Psychiatry and Psychology"]
doi:10.7717/peerj.3028
368 downloads
1,999 views

Background Illusions that alter perception of the body provide novel opportunities to target brain-based contributions to problems such as persistent pain. One example of this, mirror therapy, uses vision to augment perceived movement of a painful limb to treat...

["Neuroscience","Anaesthesiology and Pain Management","Drugs and Devices","Human-Computer Interaction"]
doi:10.7717/peerj.3023
130 downloads
609 views

Background There is a dearth of drugs to manage a dose-limiting painful peripheral neuropathy induced by paclitaxel in some patients during the treatment of cancer. Gamma-aminobutyric acid transporter-1 (GAT-1) whose expression is increased in the brain and spinal...

["Animal Behavior","Neuroscience","Anaesthesiology and Pain Management","Pharmacology"]
doi:10.7717/peerj.2798
2 citations
171 downloads
559 views

Paclitaxel, a chemotherapeutic agent, causes neuropathic pain whose supraspinal pathophysiology is not fully understood. Dysregulation of sodium channel expression, studied mainly in the periphery and spinal cord level, contributes to the pathogenesis of neuropathic...

["Molecular Biology","Neuroscience","Anaesthesiology and Pain Management","Pharmacology"]
doi:10.7717/peerj.2702
5 citations
213 downloads
610 views

Background Anesthetic postconditioning is a cellular protective approach whereby exposure to a volatile anesthetic renders a tissue more resistant to subsequent ischemic/reperfusion event. Sevoflurane postconditioning (SPostC) has been shown to exert cardioprotection...

["Cell Biology","Anaesthesiology and Pain Management","Cardiology","Diabetes and Endocrinology"]
doi:10.7717/peerj.2659
2 citations
119 downloads
476 views

Ischemic postconditioning (IPC) and ATP sensitive potassium channel (KATP) agonists (e.g. pinacidil and diazoxide) postconditioning are effective methods to defeat myocardial ischemia-reperfusion (I/R) injury, but their specific mechanisms of reducing I/R injury...

["Cell Biology","Anaesthesiology and Pain Management","Cardiology"]
doi:10.7717/peerj.2612
1 citation
349 downloads
1,077 views

Pain burden is high in people living with HIV (PLWH), but the effect of this pain on functionality is equivocal. Resilience, the ability to cope with adversity, may promote adaptation to pain, so we hypothesised that higher resilience would correlate with less...

["Anaesthesiology and Pain Management","HIV","Psychiatry and Psychology"]
doi:10.7717/peerj.2464

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