Peer-reviewed Articles - General

Telomere shortening has emerged as an important biomarker of aging. Longitudinal studies consistently find that, although telomere length shortens over time on average, there is a subset of individuals for whom telomere length is observed to increase. This apparent...

["Genetics","Genomics","Epidemiology","Statistics"]
doi:10.7717/peerj.3265
73 downloads
661 views

Background There is wide agreement in the biomedical research community that research data sharing is a primary ingredient for ensuring that science is more transparent and reproducible. Publishers could play an important role in facilitating and enforcing data...

["Ethical Issues","Science and Medical Education","Science Policy","Statistics"]
doi:10.7717/peerj.3208
126 downloads
693 views

Drug repositioning (i.e., drug repurposing) is the process of discovering new uses for marketed drugs. Historically, such discoveries were serendipitous. However, the rapid growth in electronic clinical data and text mining tools makes it feasible to systematically...

["Bioinformatics","Clinical Trials","Drugs and Devices","Oncology","Statistics"]
doi:10.7717/peerj.3154
1 citation
114 downloads
674 views

Degeneracy in the genetic code implies that different codons can encode the same amino acid. Usage preference of synonymous codons has been observed in all domains of life. There is much evidence suggesting that this bias has a major role on protein elongation...

["Bioinformatics","Genetics","Genomics","Molecular Biology","Statistics"]
doi:10.7717/peerj.3081
132 downloads
816 views

Head et al. (2015) provided a large collection of p-values that, from their perspective, indicates widespread statistical significance seeking (i.e., p-hacking). This paper inspects this result for robustness. Theoretically, the p-value distribution should be a...

["Science Policy","Statistics"]
doi:10.7717/peerj.3068
73 downloads
337 views

Background The macro environment we live in projects what we can achieve and how we behave, and in turn, shapes our health in complex ways. Policymaking will benefit from insights into the mechanisms underlying how national socioeconomic context affects health....

["Epidemiology","Global Health","Public Health","Statistics"]
doi:10.7717/peerj.3053
86 downloads
619 views

Wildlife collision data are ubiquitous, though challenging for making ecological inference due to typically irreducible uncertainty relating to the sampling process. We illustrate a new approach that is useful for generating inference from predator data arising...

["Conservation Biology","Ecology","Mathematical Biology","Statistics"]
doi:10.7717/peerj.3014
63 downloads
357 views

Interstitial lung disease (ILD) is a severe extra-articular manifestation of rheumatoid arthritis (RA) that is well-defined as a chronic systemic autoimmune disease. A proportion of patients with RA-associated ILD (RA-ILD) develop pulmonary fibrosis (PF), resulting...

["Immunology","Respiratory Medicine","Rheumatology","Statistics"]
doi:10.7717/peerj.3021
132 downloads
735 views

Background Colorectal cancer (CRC) is one of the leading cancers worldwide. Several studies have performed microarray data analyses for cancer classification and prognostic analyses. Microarray assays also enable the identification of gene signatures for molecular...

["Bioinformatics","Mathematical Biology","Molecular Biology","Oncology","Statistics"]
doi:10.7717/peerj.3003
66 downloads
612 views

Background Several recent studies have shown that total scores on depressive symptom measures in a general population approximate an exponential pattern except for the lower end of the distribution. Furthermore, we confirmed that the exponential pattern is present...

["Epidemiology","Psychiatry and Psychology","Statistics"]
doi:10.7717/peerj.2987
304 downloads
1,713 views

Marker gene sequencing of microbial communities has generated big datasets of microbial relative abundances varying across environmental conditions, sample sites and treatments. These data often come with putative phylogenies, providing unique opportunities to...

["Computational Biology","Ecology","Mathematical Biology","Microbiology","Statistics"]
doi:10.7717/peerj.2969
115 downloads
584 views

Bioinformaticians have implemented different strategies to distinguish cancer driver genes from passenger genes. One of the more recent advances uses a pathway-oriented approach. Methods that employ this strategy are highly dependent on the quality and size of...

["Bioinformatics","Computational Biology","Statistics","Computational Science"]
doi:10.7717/peerj.2568
2 citations
248 downloads
958 views

Statistical testing of trait-environment association from data is a challenge as there is no common unit of observation: the trait is observed on species, the environment on sites and the mediating abundance on species-site combinations. A number of correlation-based...

["Ecology","Statistics"]
doi:10.7717/peerj.2885
69 downloads
375 views

Background Estimates of fishing and natural mortality are important for understanding, and ultimately managing, commercial and recreational fisheries. High reward tags with fixed station acoustic telemetry provides a promising approach to monitoring mortality rates...

["Aquaculture, Fisheries and Fish Science","Computational Biology","Ecology","Statistics"]
doi:10.7717/peerj.2874
1 citation
328 downloads
1,315 views

A number of different models have been proposed as descriptions of the species-abundance distribution (SAD). Most evaluations of these models use only one or two models, focus on only a single ecosystem or taxonomic group, or fail to use appropriate statistical...

["Computational Biology","Ecology","Statistics"]
doi:10.7717/peerj.2823

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