Peer-reviewed Articles - General

22 downloads
192 views

Background CD4 cell count in adults with human immunodeficiency virus (HIV) infection (PLHIV) not receiving antiretroviral therapy (ART) influences tuberculosis (TB) risk. Despite widespread use in models informing resource allocation, this relationship has not...

["Epidemiology","Global Health","HIV","Infectious Diseases","Statistics"]
doi:10.7717/peerj.4165
63 downloads
607 views

Background Publication bias is a form of scientific misconduct. It threatens the validity of research results and the credibility of science. Although several tests on publication bias exist, no in-depth evaluations are available that examine which test performs...

["Ethical Issues","Science Policy","Statistics"]
doi:10.7717/peerj.4115
76 downloads
658 views

The amino acid content of the proteins encoded by a genome may predict the coding potential of that genome and may reflect lifestyle restrictions of the organism. Here, we calculated the Kullback–Leibler divergence from the mean amino acid content as a metric to...

["Bioinformatics","Computational Biology","Genomics","Microbiology","Statistics"]
doi:10.7717/peerj.4026
40 downloads
458 views

A recurrent question within oncology drug development is predicting phase III outcome for a new treatment using early clinical data. One approach to tackle this problem has been to derive metrics from mathematical models that describe tumour size dynamics termed...

["Mathematical Biology","Clinical Trials","Oncology","Pharmacology","Statistics"]
doi:10.7717/peerj.4111
41 downloads
219 views

Evaluation of depth of anaesthesia (DoA) is critical in clinical surgery. Indices derived from electroencephalogram (EEG) are currently widely used to quantify DoA. However, there are known to be inaccurate under certain conditions; therefore, experienced anaesthesiologists...

["Anaesthesiology and Pain Management","Statistics","Computational Science"]
doi:10.7717/peerj.4067
76 downloads
300 views

A matrix population model is a convenient tool for summarizing per capita survival and reproduction rates (collectively vital rates) of a population and can be used for calculating an asymptotic finite population growth rate (λ) and generation time. These two pieces...

["Conservation Biology","Ecology","Statistics","Natural Resource Management"]
doi:10.7717/peerj.3971
216 downloads
1,137 views

Background Differential expression analysis on the basis of RNA-Seq count data has become a standard tool in transcriptomics. Several studies have shown that prior normalization of the data is crucial for a reliable detection of transcriptional differences. Until...

["Bioinformatics","Statistics"]
doi:10.7717/peerj.3859
186 downloads
896 views

Ecological studies often are subjected to unintentional biases, suggesting that improved research designs for hypothesis testing should be used. Double-blind ecological studies are rare but necessary to minimize sampling biases and omission errors, and improve...

["Biogeography","Ecology","Entomology","Statistics"]
doi:10.7717/peerj.3903
139 downloads
663 views

RNA-Seq is a recent and efficient technique that uses the capabilities of next-generation sequencing technology for characterizing and quantifying transcriptomes. One important task using gene-expression data is to identify a small subset of genes that can be used...

["Bioinformatics","Computational Biology","Statistics","Medical Genetics","Computational Science"]
doi:10.7717/peerj.3890
89 downloads
506 views

Italian ryegrass (Lolium multiflorum) is an important cool-season, annual forage crop for the grassland rotation system in Southern China. The primary aim of breeding programs is always to seek to improve forage quality in the animal productivity system; however,...

["Agricultural Science","Biochemistry","Plant Science","Statistics"]
doi:10.7717/peerj.3867
1 citation
83 downloads
360 views

Background Respondent fatigue, also known as survey fatigue, is a common problem in the collection of survey data. Factors that are known to influence respondent fatigue include survey length, survey topic, question complexity, and open-ended question type. There...

["Anaesthesiology and Pain Management","Global Health","Statistics","Human\u2013Computer Interaction"]
doi:10.7717/peerj.3785
106 downloads
554 views

RNA sequencing (RNA-Seq) enables the measurement and comparison of gene expression with isoform-level quantification. Differences in the effect of each isoform may make traditional methods, which aggregate isoforms, ineffective. Here, we introduce a variance component-based...

["Bioinformatics","Statistics"]
doi:10.7717/peerj.3797
83 downloads
874 views

Background Cannabis use and cannabis regulatory policies recently re-surfaced as noteworthy global research and social media topics, including claims that Mexicans have been sending cannabis and other drug supplies through a porous border into the United States....

["Epidemiology","Psychiatry and Psychology","Public Health","Statistics"]
doi:10.7717/peerj.3616
161 downloads
520 views

The skyline plot is a graphical representation of historical effective population sizes as a function of time. Past population sizes for these plots are estimated from genetic data, without a priori assumptions on the mathematical function defining the shape of...

["Computational Biology","Evolutionary Studies","Genetics","Statistics"]
doi:10.7717/peerj.3530
2 citations
1,074 downloads
8,674 views

The widespread use of ‘statistical significance’ as a license for making a claim of a scientific finding leads to considerable distortion of the scientific process (according to the American Statistical Association). We review why degrading p-values into ‘significant’...

["Science Policy","Statistics"]
doi:10.7717/peerj.3544

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