Peer-reviewed Articles - Biology

97 downloads
543 views

Background The ergogenic effects of analgesic substances suggest that pain perception is an important regulator of work-rate during fatiguing exercise. Recent research has shown that endogenous inhibitory responses, which act to attenuate nociceptive input and...

["Neuroscience","Anaesthesiology and Pain Management","Neurology","Psychiatry and Psychology"]
doi:10.7717/peerj.3028
49 downloads
248 views

Background Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disease characterised by the accumulation of aggregated proteins, microglia activation and motor neuron loss. The mechanisms underlying neurodegeneration and disease progression...

["Molecular Biology","Neuroscience"]
doi:10.7717/peerj.3064
152 downloads
1,205 views

Background Illusions that alter perception of the body provide novel opportunities to target brain-based contributions to problems such as persistent pain. One example of this, mirror therapy, uses vision to augment perceived movement of a painful limb to treat...

["Neuroscience","Anaesthesiology and Pain Management","Drugs and Devices","Human-Computer Interaction"]
doi:10.7717/peerj.3023
55 downloads
282 views

Background Bax inhibitor-1 (BI-1) is an evolutionarily conserved cytoprotective transmembrane protein that acts as a suppressor of Bax-induced apoptosis by regulation of endoplasmic reticulum stress-induced cell death. We knocked down BI-1 in the sensitive dopa...

["Cell Biology","Genetics","Neuroscience"]
doi:10.7717/peerj.2974
90 downloads
887 views

Modafinil (2-((diphenylmethyl)sulfinyl)acetamide), a selective dopamine and norepinephrine transporter inhibitor, is most commonly prescribed for narcolepsy but has gained recent interest for treating a variety of disorders. Zebrafish (Danio rerio) are becoming...

["Animal Behavior","Aquaculture, Fisheries and Fish Science","Neuroscience","Pharmacology"]
doi:10.7717/peerj.2994
37 downloads
369 views

We created an easy-to-use device for operant licking experiments and another device that records environmental variables. Both devices use the Raspberry Pi computer to obtain data from multiple input devices (e.g., radio frequency identification tag readers, touch...

["Animal Behavior","Bioengineering","Neuroscience"]
doi:10.7717/peerj.2981
56 downloads
300 views

Synaptotagmin I (Syt I) is most abundant in the brain and is involved in multiple cellular processes. Its two C2 domains, C2A and C2B, are the main functional regions. Our present study employed a pull-down combined with proteomic strategy to identify the C2 domain-interacting...

["Biochemistry","Molecular Biology","Neuroscience"]
doi:10.7717/peerj.2973
180 downloads
1,008 views

Systematic studies of micronutrients during brain formation are hindered by restrictions to animal models and adult post-mortem tissues. Recently, advances in stem cell biology have enabled recapitulation of the early stages of human telencephalon development in...

["Cell Biology","Developmental Biology","Neuroscience"]
doi:10.7717/peerj.2927
111 downloads
890 views

Philosophers have long argued that causality cannot be directly observed but requires a conscious inference (Hume, 1967). Albert Michotte however developed numerous visual phenomena in which people seemed to perceive causality akin to primary visual properties...

["Neuroscience","Psychiatry and Psychology"]
doi:10.7717/peerj.2932
62 downloads
332 views

We investigated the relationship between psychometrically-defined schizotypy and the ability to detect a visual target pattern. Target detection is typically impaired by a surrounding pattern (context) with an orientation that is parallel to the target, relative...

["Neuroscience","Psychiatry and Psychology"]
doi:10.7717/peerj.2921
105 downloads
471 views

The development of the brain is sex-dimorphic, and as a result so are many neurological disorders. One approach for studying sex-dimorphic brain development is to measure gene expression in biological samples using RT-qPCR. However, the accuracy and consistency...

["Developmental Biology","Genomics","Molecular Biology","Neuroscience"]
doi:10.7717/peerj.2909
1 citation
88 downloads
537 views

The successful navigation of social interactions depends on a range of cognitive faculties—including the ability to achieve joint attention with others to share information and experiences. We investigated the influence that intention monitoring processes have...

["Neuroscience","Cognitive Disorders","Human-Computer Interaction"]
doi:10.7717/peerj.2899
507 downloads
1,140 views

Recently, there has been a move encouraged by many stakeholders towards generating big, open data in many areas of research. One area where big, open data is particularly valuable is in research relating to complex heterogeneous disorders such as Autism Spectrum...

["Bioinformatics","Neuroscience","Psychiatry and Psychology"]
doi:10.7717/peerj.2880
42 downloads
295 views

Flies use specialized photoreceptors R7 and R8 in the dorsal rim area (DRA) to detect skylight polarization. R7 and R8 form a tiered waveguide (central rhabdomere pair, CRP) with R7 on top, filtering light delivered to R8. We examine how the division of a given...

["Animal Behavior","Biophysics","Mathematical Biology","Neuroscience","Zoology"]
doi:10.7717/peerj.2772
109 downloads
447 views

Biomaterial scaffolds have the potential to enhance neuronal development and regeneration. Understanding the genetic responses of astrocytes and neurons to biomaterials could facilitate the development of synthetic environments that enable the specification of...

["Bioengineering","Bioinformatics","Cell Biology","Genomics","Neuroscience"]
doi:10.7717/peerj.2829

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