Peer-reviewed Articles - Biology

20 downloads
140 views

Piwi (P-element induced wimpy testis) is an important gene involved in stem cell maintenance and gametogenesis in vertebrates. However, in most invertebrates, especially mollusks, the function of Piwi during gametogenesis remains largely unclear. To further understand...

["Marine Biology","Molecular Biology"]
doi:10.7717/peerj.3412
37 downloads
209 views

Background Glutamate decarboxylase (GAD), as a key enzyme in the γ -aminobutyric acid (GABA) shunt, catalyzes the decarboxylation of L-glutamate to form GABA. This pathway has attracted much interest because of its roles in carbon and nitrogen metabolism, stress...

["Bioinformatics","Molecular Biology","Plant Science"]
doi:10.7717/peerj.3439
39 downloads
230 views

Background c-Kit is a receptor tyrosine kinase present in multiple cell types, including vascular smooth muscle cells (SMC). However, little is known about how c-Kit influences SMC biology and vascular pathogenesis. Methods High-throughput microarray assays and...

["Molecular Biology","Cardiology","Pharmacology"]
doi:10.7717/peerj.3418
27 downloads
214 views

Winter mortality is a major factor regulating population size of the mountain pine beetle, Dendroctonus ponderosae Hopkins (Coleoptera: Curculionidae). Glycerol is the major cryoprotectant in this freeze intolerant insect. We report findings from a gene expression...

["Ecology","Entomology","Molecular Biology","Zoology"]
doi:10.7717/peerj.3284
86 downloads
501 views

Background Within the root endosphere, fungi are known to be important for plant nutrition and resistance to stresses. However, description and understanding of the rules governing community assembly in the fungal fraction of the plant microbiome remains scarce....

["Biodiversity","Ecology","Molecular Biology","Mycology","Plant Science"]
doi:10.7717/peerj.3454
30 downloads
188 views

The evolutionarily conserved Mediator complex is a critical player in regulating transcription. Comprised of approximately two dozen proteins, the Mediator integrates diverse regulatory signals through direct protein-protein interactions that, in turn, modulate...

["Cell Biology","Developmental Biology","Evolutionary Studies","Molecular Biology"]
doi:10.7717/peerj.3390
57 downloads
328 views

Background Synthesis of thyroid hormones and regulation of their metabolism involve free radicals that may affect redox balance in the body. Thyroid disorders causing variations in the levels of thyroid hormones may alter cellular oxidative stress. The aim of this...

["Biochemistry","Molecular Biology","Oncology","Medical Genetics","Metabolic Sciences"]
doi:10.7717/peerj.3365
71 downloads
274 views

Background The veined rapa whelk Rapana venosa is an important commercial shellfish in China and quantitative real-time PCR (qRT-PCR) has become the standard method to study gene expression in R. venosa. For accurate and reliable gene expression results, qRT-PCR...

["Marine Biology","Molecular Biology"]
doi:10.7717/peerj.3398
50 downloads
368 views

Background Chronic inflammation is a characteristic of sickle cell disease (SCD), and is invariably associated with vascular endothelial injury. Hydroxyurea (HU), a naturally cytotoxic chemotherapeutic agent, is the only FDA drug approved for SCD, and is therefore...

["Cell Biology","Molecular Biology"]
doi:10.7717/peerj.3376
64 downloads
214 views

Although C-type cytoplasmic male sterility (CMS-C) is one of the most attractive tools for maize hybrid seed production, the detailed regulation network of the male sterility remains unclear. In order to identify the CMS-C sterility associated genes and/or pathways,...

["Agricultural Science","Genetics","Genomics","Molecular Biology","Plant Science"]
doi:10.7717/peerj.3408
87 downloads
461 views

Recent rapid advances in high-throughput, next-generation sequencing (NGS) technologies have promoted mitochondrial genome studies in the fields of human evolution, medical genetics, and forensic casework. However, scientists unfamiliar with computer programming...

["Genetics","Genomics","Molecular Biology"]
doi:10.7717/peerj.3406
84 downloads
392 views

Background Members of the genus Bifidobacterium are abundant in the feces of babies during the exclusively-milk-diet period of life. Bifidobacterium longum is reported to be a common member of the infant fecal microbiota. However, B. longum is composed of three...

["Microbiology","Molecular Biology"]
doi:10.7717/peerj.3375
75 downloads
308 views

Accurate species description in the marine environment is critical for estimating biodiversity and identifying genetically distinct stocks. Analysis of molecular data can potentially improve species delimitations because they are easily generated and independent,...

["Evolutionary Studies","Genetics","Marine Biology","Molecular Biology"]
doi:10.7717/peerj.3356
548 downloads
374 views

Background Sturnira is one of the most species-rich genera in the Neotropics, and it is found from Mexico and the Lesser Antilles to Argentina. This genus forms a well-supported monophyletic clade with at least twenty-one recognized species, as well as several...

["Ecology","Genetics","Molecular Biology","Zoology"]
doi:10.7717/peerj.3367
56 downloads
280 views

Identifying species groups is an important yet difficult task, with there being no single accepted definition as to what constitutes a species, nor a set of criteria by which they should be delineated. Employing the General Lineage Concept somewhat circumvents...

["Biodiversity","Genetics","Molecular Biology","Taxonomy"]
doi:10.7717/peerj.3310

Top subject areas - Articles

Top subject areas - People

View all subject areas