Peer-reviewed Articles - Biology

38 downloads
162 views

Background The NDUFS4 gene encodes an 18-kD subunit of mitochondria complex I, and mutations in this gene lead to the development of a severe neurodegenerative disease called Leigh syndrome (LS) in humans. To investigate the disease phenotypes and molecular mechanisms...

["Developmental Biology","Molecular Biology"]
doi:10.7717/peerj.3339
56 downloads
541 views

Measuring sensory sensitivity is important in studying development and developmental disorders. However, with children, there is a need to balance reliable but lengthy sensory tasks with the child’s ability to maintain motivation and vigilance. We used simulations...

["Developmental Biology","Neuroscience","Cognitive Disorders","Psychiatry and Psychology"]
doi:10.7717/peerj.3231
150 downloads
726 views

Background Lepidosaurs, a group including rhynchocephalians and squamates, are one of the major clades of extant vertebrates. Although there has been extensive phylogenetic work on this clade, its interrelationships are a matter of debate. Morphological and molecular...

["Developmental Biology","Evolutionary Studies","Zoology"]
doi:10.7717/peerj.3262
163 downloads
583 views

A small juvenile turtle is described from the Early Cretaceous Jehol Biota, shedding light on the juvenile morphology and ontogeny of Manchurochelys manchoukuoensis. Several juvenile features are uncovered, such as a small and circular carapace (less than half...

["Developmental Biology","Paleontology"]
doi:10.7717/peerj.3274
80 downloads
509 views

The appropriate timing of flowering is crucial for the reproductive success of plants. Hence, intricate genetic networks integrate various environmental and endogenous cues such as temperature or hormonal statues. These signals integrate into a network of floral...

["Bioinformatics","Computational Biology","Developmental Biology","Plant Science"]
doi:10.7717/peerj.3197
86 downloads
609 views

Background Fibroblast growth factors (FGFs) and their receptors (FGFRs) have numerous functions in the developing and adult central nervous system (CNS). For example, the FGFR1 receptor is important for proliferation and fate specification of radial glial cells...

["Developmental Biology","Neuroscience","Psychiatry and Psychology"]
doi:10.7717/peerj.3173
327 downloads
1,346 views

Synapsida, the clade including therapsids and thus also mammals, is one of the two major branches of amniotes. Organismal design, with modularity as a concept, offers insights into the evolution of therapsids, a group that experienced profound anatomical transformations...

["Developmental Biology","Evolutionary Studies","Neuroscience","Paleontology","Anatomy and Physiology"]
doi:10.7717/peerj.3119
75 downloads
426 views

Background Deficiencies in lysosomal a-mannosidase (LAM) activity in animals, caused either by mutations or by consuming toxic alkaloids, lead to severe phenotypic and behavioural consequences. Yet, epialleles adversely affecting LAM expression exist in the honey...

["Biochemistry","Developmental Biology","Molecular Biology","Toxicology"]
doi:10.7717/peerj.3109
60 downloads
310 views

Cassiopea xamachana jellyfish are an attractive model system to study metamorphosis and/or cnidarian–dinoflagellate symbiosis due to the ease of cultivation of their planula larvae and scyphistomae through their asexual cycle, in which the latter can bud new larvae...

["Developmental Biology","Marine Biology","Zoology"]
doi:10.7717/peerj.2979
67 downloads
323 views

Calcineurin (CN) is a serine/threonine phosphatase which plays important roles in meiosis maturation in invertebrate oocytes; however, the role of CN in mouse oocytes is relatively unexplored. In this study, we examined the expression, localization and functional...

["Cell Biology","Developmental Biology"]
doi:10.7717/peerj.3032
232 downloads
1,353 views

Systematic studies of micronutrients during brain formation are hindered by restrictions to animal models and adult post-mortem tissues. Recently, advances in stem cell biology have enabled recapitulation of the early stages of human telencephalon development in...

["Cell Biology","Developmental Biology","Neuroscience"]
doi:10.7717/peerj.2927
149 downloads
893 views

Larvae of malacostracan crustaceans represent a large fraction of modern day zooplankton. Plankton is not only a major part of the modern marine ecosystem, but must have played an important role in the ecosystems of the past as well. Unfortunately, our knowledge...

["Developmental Biology","Ecology","Paleontology","Zoology"]
doi:10.7717/peerj.2966
1 citation
133 downloads
438 views

Ocean warming represents a major threat to marine biota worldwide, and forecasting ecological ramifications is a high priority as atmospheric carbon dioxide (CO2) emissions continue to rise. Fitness of marine species relies critically on early developmental and...

["Developmental Biology","Ecology","Environmental Sciences","Marine Biology"]
doi:10.7717/peerj.2956
127 downloads
625 views

The development of the brain is sex-dimorphic, and as a result so are many neurological disorders. One approach for studying sex-dimorphic brain development is to measure gene expression in biological samples using RT-qPCR. However, the accuracy and consistency...

["Developmental Biology","Genomics","Molecular Biology","Neuroscience"]
doi:10.7717/peerj.2909
68 downloads
411 views

Intracellular calcium ion (Ca2+) signaling is heavily involved in development, as illustrated by the use of a number of Ca2+ indicators. However, continuous Ca2+ patterns during morphogenesis have not yet been studied using fluorescence resonance energy transfer...

["Developmental Biology","Molecular Biology"]
doi:10.7717/peerj.2894

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