Peer-reviewed Articles - Biology

18 downloads
105 views

Background Pharyngitis is an inflammatory condition of the pharynx and associated structures commonly caused by the Group A streptococci (GAS). There is a growing interest in discovering plant-based anti-inflammatory compounds as potential alternatives to conventional...

["Agricultural Science","Biochemistry","Cell Biology","Food Science and Technology","Infectious Diseases"]
doi:10.7717/peerj.3469
33 downloads
252 views

Background Stem cells are normally isolated from dental pulps using the enzymatic digestion or the outgrowth method. However, the effects of the isolation method on the quality of the isolated stem cells are not studied in detail in murine models. The aim of this...

["Biotechnology","Cell Biology"]
doi:10.7717/peerj.3180
54 downloads
297 views

TH(AGYLLGHINLHHLAHL(Aib)HHIL-NH2), a histidine-rich, cell-penetrating peptide with acid-activated pH response, designed and synthesized by our group, can effectively target tumor tissues with an acidic extracellular environment. Since the protonating effect of...

["Biochemistry","Cell Biology","Oncology"]
doi:10.7717/peerj.3429
30 downloads
188 views

The evolutionarily conserved Mediator complex is a critical player in regulating transcription. Comprised of approximately two dozen proteins, the Mediator integrates diverse regulatory signals through direct protein-protein interactions that, in turn, modulate...

["Cell Biology","Developmental Biology","Evolutionary Studies","Molecular Biology"]
doi:10.7717/peerj.3390
50 downloads
368 views

Background Chronic inflammation is a characteristic of sickle cell disease (SCD), and is invariably associated with vascular endothelial injury. Hydroxyurea (HU), a naturally cytotoxic chemotherapeutic agent, is the only FDA drug approved for SCD, and is therefore...

["Cell Biology","Molecular Biology"]
doi:10.7717/peerj.3376
28 downloads
148 views

Cucurbitacins, a class of toxic tetracyclic triterpenoids in Cucurbitaceae, modulate many molecular targets. Here we investigated the interactions of cucurbitacin B, E and I with cytoskeletal proteins such as microtubule and actin filaments. The effects of cucurbitacin...

["Cell Biology","Pharmacology"]
doi:10.7717/peerj.3357
53 downloads
193 views

Background Gregarines are a group of early branching Apicomplexa parasitizing invertebrate animals. Despite their wide distribution and relevance to the understanding the phylogenesis of apicomplexans, gregarines remain understudied: light microscopy data are insufficient...

["Cell Biology","Microbiology","Parasitology","Taxonomy","Zoology"]
doi:10.7717/peerj.3354
46 downloads
230 views

Identifying the pathways that control a cellular phenotype is the first step to building a mechanistic model. Recent examples in developmental biology, cancer genomics, and neurological disease have demonstrated how changes in the variability of gene expression...

["Bioinformatics","Cell Biology","Statistics"]
doi:10.7717/peerj.3334
50 downloads
307 views

Background Freezing is commonly used for food preservation. It is usually done under constant atmospheric pressure (isobaric). While extending the life of the produce, isobaric freezing has detrimental effects. It causes loss of food weight and changes in food...

["Agricultural Science","Biophysics","Cell Biology","Food Science and Technology","Plant Science"]
doi:10.7717/peerj.3322
58 downloads
247 views

Background Adipose-derived mesenchymal stem cells (ADSCs) have shown great potential in the treatment of various diseases. However, the optimum short-term storage condition of ADSCs in 2∼8 °C is rarely reported. This study aimed at optimizing a short-term storage...

["Biotechnology","Cell Biology","Translational Medicine"]
doi:10.7717/peerj.3301
50 downloads
243 views

Phospholipase D2 (PLD2) is involved in cytoskeletal reorganization, cell migration, cell cycle progression, transcriptional control and vesicle trafficking. There is no evidence about PLD2 function in oocytes during meiosis. Herein, we analyzed PLD2 expression...

["Cell Biology"]
doi:10.7717/peerj.3295
54 downloads
339 views

Background Pyropia haitanensis thalli, which are made of a single layer of polygonal cells, are a perfect model for studying the morphogenesis of multi-celled organisms because their cell proliferation process is an excellent example of the manner in which cells...

["Cell Biology","Mathematical Biology"]
doi:10.7717/peerj.3314
91 downloads
253 views

Background Poly-ADP-ribose (PAR) is a polymer synthesized by poly-ADP-ribose polymerases (PARPs) as a postranslational protein modification and catabolized mainly by poly-ADP-ribose glycohydrolase (PARG). In spite of the existence of cytoplasmic PARPs and PARG,...

["Cell Biology","Neuroscience","Histology"]
doi:10.7717/peerj.3318
47 downloads
321 views

Historically, Chinese herbal medicines have been widely used in the treatment of hyperglycemia, but the mechanisms underlying their effectiveness remain largely unknown. Here, we screened a compound library primarily comprised of natural compounds extracted from...

["Cell Biology","Diabetes and Endocrinology","Drugs and Devices"]
doi:10.7717/peerj.3283
43 downloads
304 views

Cations have generally been reported to prevent jellyfish venom-induced hemolysis through multiple mechanisms by spectrophotometry. Little attention has been paid to the potential interaction between cations and hemoglobin, potentially influencing the antagonistic...

["Cell Biology","Toxicology"]
doi:10.7717/peerj.3338

Top subject areas - Articles

Top subject areas - People

View all subject areas