Peer-reviewed Articles - Biology

25 downloads
217 views

Particle bombardment is a powerful and relatively easy method for transient expression of genes of interest in plant cells, especially those that are recalcitrant to other transformation methods. This method has facilitated numerous analyses of subcellular localization...

["Cell Biology","Molecular Biology","Plant Science"]
doi:10.7717/peerj.3779
63 downloads
289 views

Background Standard two-dimensional (2D) cell migration assays do not provide information about vertical invasion processes, which are critical for melanoma progression. We provide information about three-dimensional (3D) melanoma cell migration, proliferation...

["Cell Biology","Oncology","Histology"]
doi:10.7717/peerj.3754
71 downloads
307 views

Background Over the last few years multiple studies have been published showing a great diversity in size of chloroplast genomes (cpGenomes), and in the arrangement of gene clusters, in the Euglenales. However, while these genomes provided important insights into...

["Cell Biology","Evolutionary Studies","Genomics"]
doi:10.7717/peerj.3725
81 downloads
365 views

Conserved homologues of the Hrd1 ubiquitin ligase target for degradation proteins that persistently or aberrantly engage the endoplasmic reticulum translocon, including mammalian apolipoprotein B (apoB; the major protein component of low-density lipoproteins) and...

["Biochemistry","Cell Biology","Genetics","Molecular Biology"]
doi:10.7717/peerj.3728
62 downloads
284 views

Considering complicated microRNA (miRNA) biogenesis and action mechanisms, it was thought so high energy-consuming for a cell to afford simultaneous over-expression of many miRNAs. Thus it prompts that an alternative miRNA regulation pattern on protein-encoding...

["Bioinformatics","Cell Biology","Computational Biology"]
doi:10.7717/peerj.3682
35 downloads
193 views

Background Hypoxia-inducible factor (HIF)-1 is involved in the regulation of hypoxic preconditioning in cardiomyocytes. Under hypoxic conditions, HIF-1α accumulates and is translocated to the nucleus, where it forms an active complex with HIF-1β and activates transcription...

["Cell Biology","Anaesthesiology and Pain Management","Cardiology"]
doi:10.7717/peerj.3662
66 downloads
292 views

Microbial transglutaminase (mTG) was used as a crosslinking agent in the preparation of gelatin sponges. The physical properties of the materials were evaluated by measuring their material porosity, water absorption, and elastic modulus. The stability of the sponges...

["Biotechnology","Cell Biology"]
doi:10.7717/peerj.3665
66 downloads
1,042 views

Natural medicinal products possess diverse chemical structures and have been an essential source for drug discovery. Therefore, in this study, α-mangostin (AM) is a plant-derived compound was investigated for the apoptotic effect on human cervical cancer cells...

["Biochemistry","Cell Biology"]
doi:10.7717/peerj.3460
85 downloads
559 views

Breast cancer spheroids have been widely used as in vitro models of cancer stem cells (CSCs), yet little is known about their phenotypic characteristics and microRNAs (miRNAs) expression profiles. The objectives of this research were to evaluate the phenotypic...

["Cell Biology","Molecular Biology","Translational Medicine"]
doi:10.7717/peerj.3551
56 downloads
368 views

Background 2′–4′ Dinitrofluorobenzene (DNFB) induced contact hypersensitivity is an established model of contact sensitivity and leukocyte migration. Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1) deficient mice were used to examine the role of PECAM-1...

["Cell Biology","Dermatology","Immunology"]
doi:10.7717/peerj.3555
77 downloads
540 views

The fibronectin leucine rich transmembrane (FLRT) protein family consists in humans of 3 proteins, FLRT1, -2, and -3. The FLRT proteins contain two extracellular domains separated by an unstructured linker. The most membrane distal part is a leucine rich repeat...

["Biochemistry","Cell Biology","Molecular Biology","Neuroscience"]
doi:10.7717/peerj.3550
112 downloads
383 views

Melatonin is a unique multifunctional molecule that mediates reproductive functions in animals. In this study, we investigated the effects of melatonin on bovine parthenogenetic and androgenetic embryonic development, oocyte maturation, the reactive oxygen species...

["Cell Biology","Developmental Biology","Molecular Biology"]
doi:10.7717/peerj.3485
85 downloads
678 views

Background Fibroblast growth factors (FGFs) and their receptors (FGFRs) are involved in the development and function of multiple organs and organ systems, including the central nervous system (CNS). FGF signaling via FGFR1, one of the three FGFRs expressed in the...

["Cell Biology","Developmental Biology","Neuroscience"]
doi:10.7717/peerj.3519
109 downloads
380 views

Background Pharyngitis is an inflammatory condition of the pharynx and associated structures commonly caused by the Group A streptococci (GAS). There is a growing interest in discovering plant-based anti-inflammatory compounds as potential alternatives to conventional...

["Agricultural Science","Biochemistry","Cell Biology","Food Science and Technology","Infectious Diseases"]
doi:10.7717/peerj.3469
84 downloads
406 views

Background Stem cells are normally isolated from dental pulps using the enzymatic digestion or the outgrowth method. However, the effects of the isolation method on the quality of the isolated stem cells are not studied in detail in murine models. The aim of this...

["Biotechnology","Cell Biology"]
doi:10.7717/peerj.3180

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