Peer-reviewed Articles - Biology

33 downloads
198 views

Drug repositioning (i.e., drug repurposing) is the process of discovering new uses for marketed drugs. Historically, such discoveries were serendipitous. However, the rapid growth in electronic clinical data and text mining tools makes it feasible to systematically...

["Bioinformatics","Clinical Trials","Drugs and Devices","Oncology","Statistics"]
doi:10.7717/peerj.3154
45 downloads
352 views

Background Rheumatoid arthritis (RA) is a chronic auto-inflammatory disorder of joints. The present study aimed to identify the key genes in RA for better understanding the underlying mechanisms of RA. Methods The integrated analysis of expression profiling was...

["Bioinformatics","Orthopedics","Rheumatology"]
doi:10.7717/peerj.3078
66 downloads
402 views

Background Liver hepatocellular carcinoma accounts for the overwhelming majority of primary liver cancers and its belated diagnosis and poor prognosis call for novel biomarkers to be discovered, which, in the era of big data, innovative bioinformatics and computational...

["Bioinformatics","Computational Biology","Oncology","Pathology","Surgery and Surgical Specialties"]
doi:10.7717/peerj.3089
73 downloads
397 views

Hydrolysis of ATP by Na+/K+-ATPase, a P-Type ATPase, catalyzing active Na+ and K+ transport through cellular membranes leads transiently to a phosphorylation of its catalytical α-subunit. Surprisingly, three-dimensional molecular structure analysis of P-type ATPases...

["Biochemistry","Bioinformatics","Biophysics","Computational Biology","Computational Science"]
doi:10.7717/peerj.3087
22 downloads
205 views

Background Electronic Health Record (EHR)-based sepsis alert systems have failed to demonstrate improvements in clinically meaningful endpoints. However, the effect of implementation barriers on the success of new sepsis alert systems is rarely explored. Objective...

["Bioinformatics","Emergency and Critical Care","Human-Computer Interaction"]
doi:10.7717/peerj.3083
136 downloads
782 views

Background Ancient protein sequences are increasingly used to elucidate the phylogenetic relationships between extinct and extant mammalian taxa. Here, we apply these recent developments to Middle Pleistocene bone specimens of the rhinoceros genus Stephanorhinus....

["Bioinformatics","Evolutionary Studies","Molecular Biology","Paleontology"]
doi:10.7717/peerj.3033
1 citation
68 downloads
492 views

Degeneracy in the genetic code implies that different codons can encode the same amino acid. Usage preference of synonymous codons has been observed in all domains of life. There is much evidence suggesting that this bias has a major role on protein elongation...

["Bioinformatics","Genetics","Genomics","Molecular Biology","Statistics"]
doi:10.7717/peerj.3081
49 downloads
232 views

This study compared the effects of wheat- and sorghum-based diets on broiler chickens. The growth performance and caecal microbial community of chickens were measured and correlations between productivity and specific gut microbes were observed. Cobb broilers 15...

["Agricultural Science","Bioinformatics","Microbiology"]
doi:10.7717/peerj.3071
81 downloads
268 views

Background In the era of semantic web, life science ontologies play an important role in tasks such as annotating biological objects, linking relevant data pieces, and verifying data consistency. Understanding ontology structures and overlapping ontologies is essential...

["Bioinformatics","Computational Science"]
doi:10.7717/peerj.2990
37 downloads
225 views

Trypanosoma brucei brucei (TBB) belongs to the unicellular parasitic protozoa organisms, specifically to the Trypanosoma genus of the Trypanosomatidae class. A variety of different vertebrate species can be infected by TBB, including humans and animals. Under particular...

["Biochemistry","Bioinformatics","Computational Biology","Evolutionary Studies","Parasitology"]
doi:10.7717/peerj.3061
105 downloads
861 views

We present a new supertree method that enables rapid estimation of a summary tree on the scale of millions of leaves. This supertree method summarizes a collection of input phylogenies and an input taxonomy. We introduce formal goals and criteria for such a supertree...

["Bioinformatics","Computational Biology","Evolutionary Studies","Taxonomy"]
doi:10.7717/peerj.3058
68 downloads
634 views

One of the main challenges of the post-genomic era is the understanding of how gene expression is controlled. Changes in gene expression lay behind diverse biological phenomena such as development, disease and the adaptation to different environmental conditions....

["Bioinformatics","Computational Biology","Genomics"]
doi:10.7717/peerj.3052
60 downloads
305 views

Background The emergence and evolution of community-acquired methicillin resistant Staphylococcus aureus (CA-MRSA) strains in Africa is poorly understood. However, one particular MRSA lineage called ST88, appears to be rapidly establishing itself as an “African”...

["Bioinformatics","Evolutionary Studies","Genomics","Microbiology"]
doi:10.7717/peerj.3047
61 downloads
203 views

Background Polygonum minus is an herbal plant in the Polygonaceae family which is rich in ethnomedicinal plants. The chemical composition and characteristic pungent fragrance of Polygonum minus have been extensively studied due to its culinary and medicinal properties....

["Bioinformatics","Biotechnology","Genomics"]
doi:10.7717/peerj.2938
99 downloads
294 views

Circular RNAs (circRNAs) belong to a recently re-discovered species of RNA that emerge during RNA maturation through a process called back-splicing. A downstream 5′ splice site is linked to an upstream 3′ splice site to form a circular transcript instead of a canonical...

["Bioinformatics","Computational Biology","Genomics","Molecular Biology"]
doi:10.7717/peerj.2934

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