Peer-reviewed Articles - Biology

53 downloads
793 views

Background Carbonic anhydrases (CAs) are ubiquitous, essential enzymes which catalyze the conversion of carbon dioxide and water to bicarbonate and H+ ions. Vertebrate genomes generally contain gene loci for 15–21 different CA isoforms, three of which are enzymatically...

["Biochemistry","Bioinformatics","Evolutionary Studies"]
doi:10.7717/peerj.4128
30 downloads
197 views

The microtubule depolymerising kinesin-13, MCAK, is phosphorylated at residue T537 by Cdk1. This is the only known phosphorylation site within MCAK’s motor domain. To understand the impact of phosphorylation by Cdk1 on microtubule depolymerisation activity, we...

["Biochemistry","Biophysics","Molecular Biology"]
doi:10.7717/peerj.4034
30 downloads
206 views

A striking and unexpected biochemical phenotype was found in an insertion mutant line in the model plant Arabidopsis thaliana. One of two investigated insertion mutant lines in the gene encoding the phosphate transporter PHT4;1 demonstrated a prominent loss of...

["Biochemistry","Genetics","Plant Science"]
doi:10.7717/peerj.4134
83 downloads
485 views

The expression of carbonic anhydrase (CA) IX is up-regulated in many types of solid tumors in humans under hypoxic and acidic microenvironment. Inhibition of CA IX enzymatic activity with selective inhibitors, antibodies or labeled probes has been shown to reverse...

["Biochemistry","Biophysics","Drugs and Devices"]
doi:10.7717/peerj.4068
56 downloads
208 views

The wood frog (Rana sylvatica) can endure freezing of up to 65% of total body water during winter. When frozen, wood frogs enter a dormant state characterized by a cessation of vital functions (i.e., no heartbeat, blood circulation, breathing, brain activity, or...

["Biochemistry","Molecular Biology"]
doi:10.7717/peerj.4014
38 downloads
298 views

Robotic labs, in which experiments are carried out entirely by robots, have the potential to provide a reproducible and transparent foundation for performing basic biomedical laboratory experiments. In this article, we investigate whether these labs could be applicable...

["Biochemistry","Science Policy","Computational Science"]
doi:10.7717/peerj.3997
79 downloads
391 views

Background Deficiency of available forms of phosphorus is common in most soils and causes reduction of crop plants growth and yield. Recently, model plants responses to phosphate (Pi) deficiency have been intensively studied. However, acclimation mechanisms of...

["Agricultural Science","Biochemistry","Environmental Sciences","Plant Science","Soil Science"]
doi:10.7717/peerj.3989
137 downloads
497 views

Clinical evidence points to neuroprotective effects of smoking in Parkinson’s disease (PD), but the molecular mechanisms remain unclear. We investigated the pharmacological pathways involved in these neuroprotective effects, which could provide novel ideas for...

["Biochemistry","Molecular Biology","Neuroscience","Neurology","Pharmacology"]
doi:10.7717/peerj.3933
136 downloads
378 views

Increased levels of long noncoding RNA H19 (H19) have been observed in many inflammatory and organ fibrosis diseases including ulcerative colitis, osteoarthritis, liver fibrosis, renal fibrosis and pulmonary fibrosis. However, the role of H19 in bovine mastitis...

["Biochemistry","Cell Biology","Veterinary Medicine"]
doi:10.7717/peerj.3950
76 downloads
799 views

In the context of a hunt for a postulated hormone that is tissue-mass inhibiting and reproductively associated, there is described probable relatedness to a granin protein. A 7–8 kDa polypeptide candidate (gels/MS) appeared in a bioassay-guided fractionation campaign...

["Biochemistry","Cell Biology","Diabetes and Endocrinology","Neurology"]
doi:10.7717/peerj.3833
92 downloads
285 views

Background Aspergillus niger, along with many other lignocellulolytic fungi, has been widely used as a commercial workhorse for cellulase production. A fungal cellulase system generally includes three major classes of enzymes i.e., β-glucosidases, endoglucanases...

["Biochemistry","Biotechnology","Molecular Biology"]
doi:10.7717/peerj.3909
89 downloads
506 views

Italian ryegrass (Lolium multiflorum) is an important cool-season, annual forage crop for the grassland rotation system in Southern China. The primary aim of breeding programs is always to seek to improve forage quality in the animal productivity system; however,...

["Agricultural Science","Biochemistry","Plant Science","Statistics"]
doi:10.7717/peerj.3867
139 downloads
763 views

Rapid proliferation and Warburg effect make cancer cells consume plenty of glucose, which induces a low glucose micro-environment within the tumor. Up to date, how cancer cells keep proliferating in the condition of glucose insufficiency still remains to be explored....

["Biochemistry","Cell Biology","Oncology"]
doi:10.7717/peerj.3804
97 downloads
334 views

Background Food selection and ingestion both in humans and rodents, often is a critical factor in determining excess energy intake and its related disorders. Methods Two different concepts of high-fat diets were tested for their obesogenic effects in rats; in both...

["Biochemistry","Nutrition","Metabolic Sciences"]
doi:10.7717/peerj.3697
84 downloads
616 views

Energy buffering systems are key for homeostasis during variations in energy supply. Spiders are the most important predators for insects and therefore key in terrestrial ecosystems. From biomedical interest, spiders are important for their venoms and as a source...

["Biochemistry","Biophysics","Zoology","Allergy and Clinical Immunology"]
doi:10.7717/peerj.3787

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