11 downloads
35 views

The immune checkpoint plays an important role in keeping immune cells in check for protecting tissues and organs from attack by the body’s own immune system. Similar concepts also apply in how cancer cells managed to fool immune cells through the surface display...

["Biochemistry","Bioengineering","Biotechnology","Cell Biology","Computational Biology"]
doi:10.7287/peerj.preprints.27670v1
83 downloads
110 views

Therapeutic nucleic acids provide versatile treatment options for hereditary or acquired diseases. Ionic complexes with basic polymers are frequently used to facilitate nucleic acid’s transport to intracellular target sites. Usually, these polyplexes are prepared...

["Bioengineering","Biophysics","Biotechnology"]
doi:10.7287/peerj.preprints.27669v1
61 downloads
68 views

Background: Colorectal cancer (CRC) is a malignant tumor particularly common in developing countries. In this study, we used Weighted Gene Co-Expression Network Analysis (WGCNA) of chip data and screened hub genes in CRC to find the gene modules specifically correlated...

["Bioinformatics","Oncology","Pathology"]
doi:10.7287/peerj.preprints.27667v1
58 downloads
90 views

Cluster differentiation gene (CD14) is a family of monocyte differentiating genes that works in conjunction with lipopolysaccharide binding protein (LBP), forming a complex with TLR4 or LY96 to mediate innate immune response to pathogens. In this report, we used...

["Computational Biology","Evolutionary Studies","Genomics","Immunology"]
doi:10.7287/peerj.preprints.27668v1
79 downloads
124 views

Natural history museums are unique spaces for interdisciplinary research and for educational innovation. Through extensive exhibits and public programming and by hosting rich communities of amateurs, students, and researchers at all stages of their careers, they...

["Biodiversity","Ecology","Evolutionary Studies","Science Policy","Biosphere Interactions"]
doi:10.7287/peerj.preprints.27666v1
68 downloads
84 views

Background: Nontyphoidal Salmonella spp. transmitted through various routes are a major concern of food poisoning due to the consumption of contaminated food. Objective: To establish a molecular-based protocol for simple and rapid subtyping of Salmonella isolates...

["Microbiology","Molecular Biology","Epidemiology"]
doi:10.7287/peerj.preprints.27664v1
72 downloads
74 views

Background. In recent years, the scientific community encouraged the use of raw data graphs to improve the reliability and transparency of the results presented in papers. However, methods to visualize raw data are limited to one variable per graph and/or only...

["Bioinformatics","Science and Medical Education","Statistics","Data Science"]
doi:10.7287/peerj.preprints.27665v1
63 downloads
105 views

Background The aim of the study was to explore the viewpoints of healthcare professionals (HCPs) on the adoption and use of eHealth in clinical practice in sub-Saharan Africa (SSA). Information and communication technologies (ICTs) including eHealth provide HCPs...

["Nursing","Human\u2013Computer Interaction"]
doi:10.7717/peerj.6326
124 downloads
160 views

Background The bushbuck, Tragelaphus scriptus, is a widespread and ecologically diverse ungulate species complex within the spiral-horned antelopes. This species was recently found to consist of two genetically divergent but monophyletic lineages, which are paraphyletic...

["Biodiversity","Biogeography","Conservation Biology","Genetics","Zoology"]
doi:10.7717/peerj.6476
23 downloads
69 views

Background There is little research on differences in Emotional Intelligence (EI) ability at different stages of adult development. The few published studies tend not to use older adult samples. Previous studies on EI ability and age have shown contradictory results....

["Geriatrics","Psychiatry and Psychology"]
doi:10.7717/peerj.6595
132 downloads
719 views

The recent discovery of the Araguaian river dolphin (Inia araguaiaensis) highlights how little we know about the diversity and biology of river dolphins. In this study, we described the acoustic repertoire of this newly discovered species in concert with their...

["Animal Behavior","Biodiversity","Ecology","Zoology","Freshwater Biology"]
doi:10.7717/peerj.6670
148 downloads
140 views

The coccolithophore Emiliania huxleyi forms some of the largest phytoplankton blooms in the ocean. The rapid demise of these blooms has been linked to viral infections. E. huxleyi abundance, distribution, and nutritional status make them an important food source...

["Marine Biology","Microbiology","Virology","Biological Oceanography"]
doi:10.7717/peerj.6722
72 downloads
105 views

Background Phthalates are man-made chemical compounds with numerous applications especially known for their use as plasticizers. They have weak bonding to the polymeric matrix or products in which they are used. Owing to this reason, they are readily released into...

["Agricultural Science","Plant Science","Ecotoxicology"]
doi:10.7717/peerj.6742
80 downloads
99 views

Marine algae have been reported as important sources of biogenic volatile halocarbons that are emitted into the atmosphere. These compounds are linked to destruction of the ozone layer, thus contributing to climate change. There may be mutual interactions between...

["Marine Biology","Biosphere Interactions","Climate Change Biology","Biogeochemistry","Environmental Impacts"]
doi:10.7717/peerj.6758
75 downloads
85 views

Individual trait variation is essential for populations to cope with multiple stressors and continuously changing environments. The immense number of possible stressor combinations and the influence of phenotypic variation makes experimental testing for effects...

["Marine Biology","Toxicology","Ecotoxicology"]
doi:10.7717/peerj.6776

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