Background Arachidonic acid (AA) is oxidized by cytochrome P450s (CYPs) to form epoxyeicosatrienoic acids (EETs), compounds that modulate ion transport, gene expression, and vasorelaxation. Both CYP2Cs and CYP2Js are involved in kidney EET epoxidation. Methods...

["Biochemistry","Molecular Biology"]

The mechanisms underlying the oncogenesis and progression of lung adenocarcinoma (LUAD) are currently unclear. The discovery of competitive endogenous RNA (ceRNA) regulatory networks has provided a new direction for the treatment and prognosis of patients with...

["Bioinformatics","Computational Biology","Genetics"]

Background Quantitative real-time polymerase chain reaction (RT-qPCR) is a sensitive method for quantifying mRNA abundance. With relative expression analysis, however, reliable data output is dependent on stably expressed reference genes across the samples being...

["Developmental Biology","Molecular Biology","Pediatrics"]

Snippets of virus that infect humans have been shown to be incorporated into the human genome. Could such virus snippets provide a form of adaptive immunity similar to that offered by CRISPR to bacterial cells? To answer the question, RNA-seq could be used to provide...

["Biochemistry","Bioinformatics","Cell Biology","Genomics","Molecular Biology"]

APYRASEs, which directly regulated the intra- and extra-cellular ATP homeostasis, plays a pivotal role in the regulation of the adaptations to various stresses in mammals, bacteria and plants. In the present study, we identified and characterized the wheat APYRASE...

["Genomics","Plant Science"]

Background: Among all present demosponges, lithistids represent a polyphyletic group with exceptionally well preserved fossils dating back to the Cambrian. Knowledge of their recent diversity, particularly in the Tropical Western Atlantic Ocean (TWA) where they...

["Biodiversity","Evolutionary Studies","Marine Biology","Taxonomy"]
1 download
1 view

Background Conventional methods used to identify BRCA1 and BRCA2 germline mutations in hereditary cancers, such as Sanger sequencing/multiplex ligation-dependent probe amplification (MLPA), are time-consuming and expensive, due to the large size of the genes. The...

["Genetics","Genomics","Oncology","Women\u2019s Health"]
1 download
1 view

Background Dengue caused by dengue virus (DENV) serotypes −1 to −4 is the most important mosquito-borne viral disease in the tropical and sub-tropical countries worldwide. Yet many of the pathophysiological mechanisms of host responses during DENV infection remain...

["Bioinformatics","Genomics","Virology","Infectious Diseases"]
1 download
1 view

Background Cervical cancer (CC) is a common gynecological malignancy in women worldwide. Evidence suggests that long non-coding RNAs (lncRNAs) can be used as biomarkers in patients with CC. However, prognostic biomarkers for CC are still lacking. The aim of our...

["Bioinformatics","Genomics","Gynecology and Obstetrics","Oncology","Public Health"]

Emerging from the information-theoretic characterization of secrecy, physical-layer security exploits the physical properties of the wireless channel for security purpose. In recent years, a great deal of attention has been paid to investigating the physical-layer...

["Computer Networks and Communications","Security and Privacy"]
1 download
1 view

The U.S. Endangered Species Act is one of the strongest laws of any nation for preventing species extinction, but quantifying the Act’s effectiveness has proven difficult. To provide one measure of effectiveness, we identified listed species that have gone extinct...

["Biodiversity","Conservation Biology","Science Policy"]

Background In northern European and North American cities geese are one of the commonest and most visible large herbivores that inhabit the suburban environment . As such, their presence and behavior often conflicts with the desires of the human residents. Fouling,...

["Animal Behavior","Ecology"]

The sirtuin family contains seven proteins with the functions in multiple diseases of aging, which makes them an attractive subject for the development of therapies of age-related diseases and anti-aging treatments. The primary objective of the protein-interaction...

["Biochemistry","Bioinformatics","Computational Science","Data Mining and Machine Learning"]

The immune checkpoint plays an important role in keeping immune cells in check for protecting tissues and organs from attack by the body’s own immune system. Similar concepts also apply in how cancer cells managed to fool immune cells through the surface display...

["Biochemistry","Bioengineering","Biotechnology","Cell Biology","Computational Biology"]

Therapeutic nucleic acids provide versatile treatment options for hereditary or acquired diseases. Ionic complexes with basic polymers are frequently used to facilitate nucleic acid’s transport to intracellular target sites. Usually, these polyplexes are prepared...


Top subject areas - Articles & Preprints

Top subject areas - People

View all subject areas