1 download
1 view

Background Conventional methods used to identify BRCA1 and BRCA2 germline mutations in hereditary cancers, such as Sanger sequencing/multiplex ligation-dependent probe amplification (MLPA), are time-consuming and expensive, due to the large size of the genes. The...

["Genetics","Genomics","Oncology","Women\u2019s Health"]
doi:10.7717/peerj.6661
1 download
1 view

Background Dengue caused by dengue virus (DENV) serotypes −1 to −4 is the most important mosquito-borne viral disease in the tropical and sub-tropical countries worldwide. Yet many of the pathophysiological mechanisms of host responses during DENV infection remain...

["Bioinformatics","Genomics","Virology","Infectious Diseases"]
doi:10.7717/peerj.6697
1 download
1 view

Background Cervical cancer (CC) is a common gynecological malignancy in women worldwide. Evidence suggests that long non-coding RNAs (lncRNAs) can be used as biomarkers in patients with CC. However, prognostic biomarkers for CC are still lacking. The aim of our...

["Bioinformatics","Genomics","Gynecology and Obstetrics","Oncology","Public Health"]
doi:10.7717/peerj.6761

Emerging from the information-theoretic characterization of secrecy, physical-layer security exploits the physical properties of the wireless channel for security purpose. In recent years, a great deal of attention has been paid to investigating the physical-layer...

["Computer Networks and Communications","Security and Privacy"]
doi:10.7717/peerj-cs.186
1 download
1 view

The U.S. Endangered Species Act is one of the strongest laws of any nation for preventing species extinction, but quantifying the Act’s effectiveness has proven difficult. To provide one measure of effectiveness, we identified listed species that have gone extinct...

["Biodiversity","Conservation Biology","Science Policy"]
doi:10.7717/peerj.6803
25 downloads
43 views

Background In northern European and North American cities geese are one of the commonest and most visible large herbivores that inhabit the suburban environment . As such, their presence and behavior often conflicts with the desires of the human residents. Fouling,...

["Animal Behavior","Ecology"]
doi:10.7287/peerj.preprints.27672v1
17 downloads
42 views

The sirtuin family contains seven proteins with the functions in multiple diseases of aging, which makes them an attractive subject for the development of therapies of age-related diseases and anti-aging treatments. The primary objective of the protein-interaction...

["Biochemistry","Bioinformatics","Computational Science","Data Mining and Machine Learning"]
doi:10.7287/peerj.preprints.27671v1
34 downloads
61 views

The immune checkpoint plays an important role in keeping immune cells in check for protecting tissues and organs from attack by the body’s own immune system. Similar concepts also apply in how cancer cells managed to fool immune cells through the surface display...

["Biochemistry","Bioengineering","Biotechnology","Cell Biology","Computational Biology"]
doi:10.7287/peerj.preprints.27670v1
153 downloads
142 views

Therapeutic nucleic acids provide versatile treatment options for hereditary or acquired diseases. Ionic complexes with basic polymers are frequently used to facilitate nucleic acid’s transport to intracellular target sites. Usually, these polyplexes are prepared...

["Bioengineering","Biophysics","Biotechnology"]
doi:10.7287/peerj.preprints.27669v1
67 downloads
78 views

Background: Colorectal cancer (CRC) is a malignant tumor particularly common in developing countries. In this study, we used Weighted Gene Co-Expression Network Analysis (WGCNA) of chip data and screened hub genes in CRC to find the gene modules specifically correlated...

["Bioinformatics","Oncology","Pathology"]
doi:10.7287/peerj.preprints.27667v1
65 downloads
97 views

Cluster differentiation gene (CD14) is a family of monocyte differentiating genes that works in conjunction with lipopolysaccharide binding protein (LBP), forming a complex with TLR4 or LY96 to mediate innate immune response to pathogens. In this report, we used...

["Computational Biology","Evolutionary Studies","Genomics","Immunology"]
doi:10.7287/peerj.preprints.27668v1
84 downloads
136 views

Natural history museums are unique spaces for interdisciplinary research and for educational innovation. Through extensive exhibits and public programming and by hosting rich communities of amateurs, students, and researchers at all stages of their careers, they...

["Biodiversity","Ecology","Evolutionary Studies","Science Policy","Biosphere Interactions"]
doi:10.7287/peerj.preprints.27666v1
72 downloads
95 views

Background: Nontyphoidal Salmonella spp. transmitted through various routes are a major concern of food poisoning due to the consumption of contaminated food. Objective: To establish a molecular-based protocol for simple and rapid subtyping of Salmonella isolates...

["Microbiology","Molecular Biology","Epidemiology"]
doi:10.7287/peerj.preprints.27664v1
73 downloads
80 views

Background. In recent years, the scientific community encouraged the use of raw data graphs to improve the reliability and transparency of the results presented in papers. However, methods to visualize raw data are limited to one variable per graph and/or only...

["Bioinformatics","Science and Medical Education","Statistics","Data Science"]
doi:10.7287/peerj.preprints.27665v1
72 downloads
115 views

Background The aim of the study was to explore the viewpoints of healthcare professionals (HCPs) on the adoption and use of eHealth in clinical practice in sub-Saharan Africa (SSA). Information and communication technologies (ICTs) including eHealth provide HCPs...

["Nursing","Human\u2013Computer Interaction"]
doi:10.7717/peerj.6326

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