2 downloads
2 views

The “bidirectional gene pair” indicates a particular head-to-head gene organization in which transcription start sites of two genes are located on opposite strands of genomic DNA within a region of one kb. Despite bidirectional gene pairs are well characterized,...

["Bioinformatics","Genomics"]
doi:10.7717/peerj.7107
1 download
1 view

Background Sepsis represents a significant healthcare problem worldwide and causes a high number of deaths every year but remains to be fully understood. During and after sepsis, the host immune response is complex and involves an initial excessive host inflammatory...

["Emergency and Critical Care","Hematology","Immunology","Infectious Diseases"]
doi:10.7717/peerj.7116
1 download
1 view

Neurotrophic receptor tyrosine kinase 2 (NTRK2) is a member of the tropomyosin receptor kinase family associated with the tumor development. However, the detailed function of NTRK2 in lung cancer, especially in lung adenocarcinoma (LUAD), is still not fully understood....

["Bioinformatics","Oncology","Pharmacology","Respiratory Medicine"]
doi:10.7717/peerj.7125
2 downloads
2 views

Protein–protein interactions are closely relevant to protein function and drug discovery. Hence, accurately identifying protein–protein interactions will help us to understand the underlying molecular mechanisms and significantly facilitate the drug discovery....

["Bioinformatics","Computational Biology","Data Mining and Machine Learning"]
doi:10.7717/peerj.7126
2 downloads
1 view

Selection from phage display libraries empowers isolation of high-affinity ligands for various targets. However, this method also identifies propagation-related target-unrelated peptides (PrTUPs). These false positive hits appear because of their amplification...

["Bioinformatics","Data Mining and Machine Learning"]
doi:10.7717/peerj.7131
1 download
1 view

Background Pulpitis is a common inflammatory disease that affects dental pulp. It is important to understand the molecular signals of inflammation and repair associated with this process. Increasing evidence has revealed that long noncoding RNAs (lncRNAs), via...

["Bioinformatics","Dentistry"]
doi:10.7717/peerj.7135
2 downloads
1 view

Background Insect neuropeptides are interesting for the potential their receptors hold as plausible targets for a novel generation of pesticides. Neuropeptide genes have been identified in a number of different species belonging to a variety of insects. Results...

["Bioinformatics","Entomology","Genomics","Neuroscience","Zoology"]
doi:10.7717/peerj.7144
1 download
1 view

Background Bile acids are important metabolites of intestinal microbiota, which have profound effects on host health. However, whether metabolism of bile acids is involved in the metabolic complications of end-stage renal disease (ESRD), and the effects of bile...

["Internal Medicine","Nephrology"]
doi:10.7717/peerj.7145
1 download
2 views

The Qinghai-Tibet Plateau (QTP) is experiencing severe permafrost degradation, which can affect the hydrological and biogeochemical processes. Yet how the permafrost change affects riverine carbon export remains uncertain. Here, we investigated the seasonal variations...

["Biogeochemistry","Environmental Impacts"]
doi:10.7717/peerj.7146
13 downloads
43 views

Background: Tick-borne diseases are frequent in the Southeastern section of Brazil. The most prevalent canine parasites diagnosed are Ehrlichia canis, Babesia gibsoni, Babesia canis and Anaplasma platys, although Mycoplasma haemocanis and candidatus Mycoplasma...

["Veterinary Medicine","Epidemiology"]
doi:10.7287/peerj.preprints.27805v1
51 downloads
54 views

The activity of genome-specific repetitive sequence is the main cause of the genome variation between Gossypium A and D genomes. Through the comparative analysis of the two genomes, we got a repetitive element (ICRd motif), which repeats massively in the diploid...

["Agricultural Science","Evolutionary Studies","Genetics","Genomics","Plant Science"]
doi:10.7287/peerj.preprints.27806v1
22 downloads
84 views

Sequencing data resources have increased exponentially in recent years, as has interest in large-scale meta-analyses of integrated next-generation sequencing datasets. However, curation of integrated datasets that match a user’s particular research priorities is...

["Bioinformatics","Data Science"]
doi:10.7287/peerj.preprints.27804v1
19 downloads
44 views

Background: L-Methionine sulfoximine (MSO) inhibits glutamine synthesis in a rodent animal model, and its limited clinical use is implicitly associated with glutamate deprivation and neurotoxicity. The purpose of this experiment was to determine the effect of MSO...

["Cell Biology","Toxicology","Drugs and Devices"]
doi:10.7287/peerj.preprints.27803v1
41 downloads
130 views

For the 2018 YPIC Challenge contestants were invited to try to decipher two unknown English questions encoded by a synthetic protein expressed in Escherichia coli. In addition to deciphering the sentence, contestants were asked to determine the 3D structure and...

["Bioinformatics","Molecular Biology"]
doi:10.7287/peerj.preprints.27802v1
15 downloads
29 views

It is important to get data with Signal-Noise-Ratios (SNR) as high as possible. Compared to other techniques, filtering methods are fast. But they do not make full use of the characteristics of sample structure which reflected by relevant high SNR images. In this...

["Computer Vision","Visual Analytics"]
doi:10.7287/peerj.preprints.27800v1

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