315 downloads
389 views

Protein–protein interactions are closely relevant to protein function and drug discovery. Hence, accurately identifying protein–protein interactions will help us to understand the underlying molecular mechanisms and significantly facilitate the drug discovery....

["Bioinformatics","Computational Biology","Data Mining and Machine Learning"]
doi:10.7717/peerj.7126
74 downloads
201 views

Selection from phage display libraries empowers isolation of high-affinity ligands for various targets. However, this method also identifies propagation-related target-unrelated peptides (PrTUPs). These false positive hits appear because of their amplification...

["Bioinformatics","Data Mining and Machine Learning"]
doi:10.7717/peerj.7131
156 downloads
166 views

Background Pulpitis is a common inflammatory disease that affects dental pulp. It is important to understand the molecular signals of inflammation and repair associated with this process. Increasing evidence has revealed that long noncoding RNAs (lncRNAs), via...

["Bioinformatics","Dentistry"]
doi:10.7717/peerj.7135
149 downloads
257 views

Background Insect neuropeptides are interesting for the potential their receptors hold as plausible targets for a novel generation of pesticides. Neuropeptide genes have been identified in a number of different species belonging to a variety of insects. Results...

["Bioinformatics","Entomology","Genomics","Neuroscience","Zoology"]
doi:10.7717/peerj.7144
111 downloads
178 views

Background Bile acids are important metabolites of intestinal microbiota, which have profound effects on host health. However, whether metabolism of bile acids is involved in the metabolic complications of end-stage renal disease (ESRD), and the effects of bile...

["Internal Medicine","Nephrology"]
doi:10.7717/peerj.7145
166 downloads
178 views

The Qinghai-Tibet Plateau (QTP) is experiencing severe permafrost degradation, which can affect the hydrological and biogeochemical processes. Yet how the permafrost change affects riverine carbon export remains uncertain. Here, we investigated the seasonal variations...

["Biogeochemistry","Environmental Impacts"]
doi:10.7717/peerj.7146
42 downloads
114 views

Background: Tick-borne diseases are frequent in the Southeastern section of Brazil. The most prevalent canine parasites diagnosed are Ehrlichia canis, Babesia gibsoni, Babesia canis and Anaplasma platys, although Mycoplasma haemocanis and candidatus Mycoplasma...

["Veterinary Medicine","Epidemiology"]
doi:10.7287/peerj.preprints.27805v1
123 downloads
153 views

The activity of genome-specific repetitive sequence is the main cause of the genome variation between Gossypium A and D genomes. Through the comparative analysis of the two genomes, we got a repetitive element (ICRd motif), which repeats massively in the diploid...

["Agricultural Science","Evolutionary Studies","Genetics","Genomics","Plant Science"]
doi:10.7287/peerj.preprints.27806v1
81 downloads
206 views

Sequencing data resources have increased exponentially in recent years, as has interest in large-scale meta-analyses of integrated next-generation sequencing datasets. However, curation of integrated datasets that match a user’s particular research priorities is...

["Bioinformatics","Data Science"]
doi:10.7287/peerj.preprints.27804v1
46 downloads
100 views

Background: L-Methionine sulfoximine (MSO) inhibits glutamine synthesis in a rodent animal model, and its limited clinical use is implicitly associated with glutamate deprivation and neurotoxicity. The purpose of this experiment was to determine the effect of MSO...

["Cell Biology","Toxicology","Drugs and Devices"]
doi:10.7287/peerj.preprints.27803v1
75 downloads
194 views

For the 2018 YPIC Challenge contestants were invited to try to decipher two unknown English questions encoded by a synthetic protein expressed in Escherichia coli. In addition to deciphering the sentence, contestants were asked to determine the 3D structure and...

["Bioinformatics","Molecular Biology"]
doi:10.7287/peerj.preprints.27802v1
33 downloads
59 views

It is important to get data with Signal-Noise-Ratios (SNR) as high as possible. Compared to other techniques, filtering methods are fast. But they do not make full use of the characteristics of sample structure which reflected by relevant high SNR images. In this...

["Computer Vision","Visual Analytics"]
doi:10.7287/peerj.preprints.27800v1
64 downloads
143 views

The expansion of research in forensic neuropsychiatric practice has led to several developments with an interdisciplinary focus in legal systems and psychiatry around the globe. Given the dearth of scientometric analyses in this area, this article will help increase...

["Psychiatry and Psychology"]
doi:10.7287/peerj.preprints.27799v1
344 downloads
569 views

Metabarcoding can rapidly determine the species composition of bulk samples and thus aids ecosystem assessment. However , it is essential to use primer sets that minimize amplification bias among taxa to maximize species recovery. Despite this fact, the performance...

["Ecology","Ecosystem Science","Entomology","Molecular Biology","Forestry"]
doi:10.7287/peerj.preprints.27801v1
83 downloads
369 views

Background Processed seafood products are not readily identifiable based on physical characteristics, which leaves the industry vulnerable to high levels of product mislabelling (globally estimated at 5–30% mislabelled). This is both a food safety issue and a consumer...

["Aquaculture, Fisheries and Fish Science","Biodiversity","Taxonomy","Science and Medical Education","Natural Resource Management"]
doi:10.7717/peerj.7138

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