160 downloads
217 views

Background The Oxford Acute Severity of Illness Score (OASIS) has shown fair prognosis predictive value in critically ill patients, but its predictive value has not been assessed in septic patients. Objective The aim of this study was to evaluate the performance...

["Emergency and Critical Care","Hematology","Infectious Diseases","Internal Medicine"]
doi:10.7717/peerj.7083
86 downloads
204 views

Background The plasminogen activation system plays a pivotal role in regulating tumorigenesis. In this work, we aim to identify key regulators of plasminogen activation associated with tumorigenesis and explore potential mechanisms in gastric cancer (GC). Methods...

["Bioinformatics","Genomics","Gastroenterology and Hepatology"]
doi:10.7717/peerj.7091
70 downloads
113 views

Background Studies have shown that the occurrence and development of IgA nephropathy (IgAN) are genetically susceptible, but the relationship between vitamin D receptor (VDR) gene polymorphisms and renal function in IgAN patients is unclear. Methods We investigated...

["Diabetes and Endocrinology","Nephrology","Medical Genetics"]
doi:10.7717/peerj.7092
74 downloads
295 views

Kinematic behavior during fast cervical rotations is a useful parameter for assessing sensorimotor control performances in neck-pain patients. However, the influence of age in asymptomatic individuals from children to older people still needs to be explored. Our...

["Anesthesiology and Pain Management","Evidence Based Medicine","Geriatrics","Kinesiology","Orthopedics"]
doi:10.7717/peerj.7095
82 downloads
165 views

The rise of high-throughput methods in genomic research greatly expanded our knowledge about the functionality of the genome. At the same time, the amount of available genomic position data increased massively, e.g., through genome-wide profiling of protein binding,...

["Bioinformatics","Computational Biology"]
doi:10.7717/peerj-cs.198
73 downloads
141 views

Appropriate embedding transformation of sentences can aid in downstream tasks such as NLP and emotion and behavior analysis. Such efforts evolved from word vectors which were trained in an unsupervised manner using large-scale corpora. Recent research, however,...

["Artificial Intelligence","Natural Language and Speech"]
doi:10.7717/peerj-cs.200
91 downloads
147 views

The type II toxin antitoxin (TA) system is the most well-studied TA system and is widely distributed in bacteria, especially pathogens such as Mycobacterium tuberculosis. Type II TA system plays an important role in many cellular processes, including maintaining...

["Microbiology","Molecular Biology"]
doi:10.7287/peerj.preprints.27770v2
49 downloads
93 views

The present manuscript explores signalling and metabolic pathways which mediate functions of Tripeptidyl-peptidase 2 (TPP2) using the analysis of its protein-protein interaction network. The protein interaction data were retrieved partially from our previous experimental...

["Biochemistry","Bioinformatics","Computational Science"]
doi:10.7287/peerj.preprints.27789v1
127 downloads
365 views

The possibility of gene editing to correct disorders is one of the most impactful therapeutic agents, currently. CRISPR Cas9-sgRNA nucleases can be used to cleave and to delete harmful or pathogenic DNA sequences, which cause genetic disorders. Cas9 nuclease with...

["Cell Biology","Microbiology","Plant Science","Immunology","Synthetic Biology"]
doi:10.7287/peerj.preprints.27709v2
41 downloads
57 views

The use of mechanical alloying in this work leads to a solid solution Mg0.33Al0.66 instead of Laves phase MgAl2. Monosubstituted alloy Mg0.33Al0.63Si0.03 was obtained in good yield after 20 hours mechanical alloying with shock power of 6.5 W/g. Current work in...

["Alloys","Energy Materials","Metamaterials","Nano and Microstructured Materials","Porous Materials"]
doi:10.7287/peerj.preprints.27788v1
258 downloads
667 views

Recent advances in omics technologies have led to the broad applicability of computational techniques across various domains of life science and medical research. These technologies provide an unprecedented opportunity to collect omics data from hundreds of thousands...

["Computational Biology","Genomics","Science and Medical Education","Computational Science"]
doi:10.7287/peerj.preprints.27603v2
203 downloads
434 views

Background Diversification patterns in the Himalayas have been important to our understanding of global biodiversity. Despite recent broad-scale studies, the most diverse angiosperm genus of the temperate zone—Carex L. (Cyperaceae), with ca. 2100 species worldwide—has...

["Biodiversity","Biogeography","Ecology","Evolutionary Studies","Plant Science"]
doi:10.7717/peerj.6792
123 downloads
336 views

Octopus oliveri is a widespread and common rocky intertidal cephalopod that mates readily in the laboratory, but for which mating behavior has not been reported previously. Four sets of behavioral experiments were recorded wherein three males, small, medium & large...

["Animal Behavior","Ecology","Genetics","Marine Biology"]
doi:10.7717/peerj.6927
107 downloads
787 views

The mole snake (Pseudaspis cana) is capable of inflicting unusual bites in defence and during male combat that present as two parallel lacerations. We investigated the dental morphology of the mole snake by making SEM images, and by CT-scanning and digitally reconstructing...

["Evolutionary Studies","Zoology"]
doi:10.7717/peerj.6943
112 downloads
286 views

Changes in behavior are often the proximate response of animals to human disturbance, with variability in tolerance levels leading some species to exhibit striking shifts in life history, fitness, and/or survival. Thus, elucidating the effects of disturbance on...

["Animal Behavior","Ecology","Zoology","Natural Resource Management","Environmental Impacts"]
doi:10.7717/peerj.6956

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