125 downloads
359 views

The possibility of gene editing to correct disorders is one of the most impactful therapeutic agents, currently. CRISPR Cas9-sgRNA nucleases can be used to cleave and to delete harmful or pathogenic DNA sequences, which cause genetic disorders. Cas9 nuclease with...

["Cell Biology","Microbiology","Plant Science","Immunology","Synthetic Biology"]
doi:10.7287/peerj.preprints.27709v2
37 downloads
52 views

The use of mechanical alloying in this work leads to a solid solution Mg0.33Al0.66 instead of Laves phase MgAl2. Monosubstituted alloy Mg0.33Al0.63Si0.03 was obtained in good yield after 20 hours mechanical alloying with shock power of 6.5 W/g. Current work in...

["Alloys","Energy Materials","Metamaterials","Nano and Microstructured Materials","Porous Materials"]
doi:10.7287/peerj.preprints.27788v1
253 downloads
661 views

Recent advances in omics technologies have led to the broad applicability of computational techniques across various domains of life science and medical research. These technologies provide an unprecedented opportunity to collect omics data from hundreds of thousands...

["Computational Biology","Genomics","Science and Medical Education","Computational Science"]
doi:10.7287/peerj.preprints.27603v2
191 downloads
410 views

Background Diversification patterns in the Himalayas have been important to our understanding of global biodiversity. Despite recent broad-scale studies, the most diverse angiosperm genus of the temperate zone—Carex L. (Cyperaceae), with ca. 2100 species worldwide—has...

["Biodiversity","Biogeography","Ecology","Evolutionary Studies","Plant Science"]
doi:10.7717/peerj.6792
85 downloads
280 views

Octopus oliveri is a widespread and common rocky intertidal cephalopod that mates readily in the laboratory, but for which mating behavior has not been reported previously. Four sets of behavioral experiments were recorded wherein three males, small, medium & large...

["Animal Behavior","Ecology","Genetics","Marine Biology"]
doi:10.7717/peerj.6927
101 downloads
759 views

The mole snake (Pseudaspis cana) is capable of inflicting unusual bites in defence and during male combat that present as two parallel lacerations. We investigated the dental morphology of the mole snake by making SEM images, and by CT-scanning and digitally reconstructing...

["Evolutionary Studies","Zoology"]
doi:10.7717/peerj.6943
102 downloads
260 views

Changes in behavior are often the proximate response of animals to human disturbance, with variability in tolerance levels leading some species to exhibit striking shifts in life history, fitness, and/or survival. Thus, elucidating the effects of disturbance on...

["Animal Behavior","Ecology","Zoology","Natural Resource Management","Environmental Impacts"]
doi:10.7717/peerj.6956
59 downloads
175 views

Excessive alcohol consumption is a risk factor for liver diseases. Enhancement of alcohol metabolism could be an effective strategy to prevent these adverse effects since it promotes the clearance of ethanol and acetaldehyde from the serum. Polyphenol-rich products...

["Food Science and Technology","Metabolic Sciences"]
doi:10.7717/peerj.6989
117 downloads
417 views

Background The current study applies both traditional and Diffusible Iodine Contrast Enhanced computed microtomography (DICE µCT) techniques to reveal the musculoskeletal anatomy of Phlyctimantis maculatus. DICE µCT has emerged as a powerful tool to visualise intricate...

["Evolutionary Studies","Zoology","Anatomy and Physiology"]
doi:10.7717/peerj.7003
118 downloads
189 views

The genome-scale metabolic model of a lipid-overproducing strain of Mucor circinelloides WJ11 was developed. The model (iNI1159) contained 1,159 genes, 648 EC numbers, 1,537 metabolites, and 1,355 metabolic reactions, which were localized in different compartments...

["Bioinformatics","Genomics","Mycology"]
doi:10.7717/peerj.7015
55 downloads
148 views

The impacts of continued degradation of watersheds on coastal coral reefs world-wide is alarming, and action addressing anthropogenic stressors and subsequent rehabilitation of watersheds and adjacent reefs is an urgent priority. The aim of this study is to develop...

["Biochemistry","Conservation Biology","Marine Biology","Molecular Biology"]
doi:10.7717/peerj.7020
90 downloads
151 views

This study reports the whole chloroplast genome of Fagus crenata (subgenus Fagus), a foundation tree species of Japanese temperate forests. The genome has a total of 158,227 bp containing 111 genes, including 76 protein-coding genes, 31 tRNA genes and 4 ribosomal...

["Biodiversity","Evolutionary Studies","Genetics","Plant Science"]
doi:10.7717/peerj.7026
59 downloads
177 views

When an individual attends to certain types of information more than others, the behavior is termed an attention bias. The occurrence of attention biases in humans and animals can depend on their affective states. Based on evidence from the human literature and...

["Agricultural Science","Animal Behavior"]
doi:10.7717/peerj.7033
54 downloads
173 views

Background Although pathogenic Gram-negative bacteria lack their own ubiquitination machinery, they have evolved or acquired virulence effectors that can manipulate the host ubiquitination process through structural and/or functional mimicry of host machinery....

["Bioinformatics","Computational Biology","Microbiology","Infectious Diseases","Data Mining and Machine Learning"]
doi:10.7717/peerj.7055
44 downloads
135 views

Urbanization is one of the most significant land cover transformations, and while climate alteration is one of its most cited ecological consequences we have very limited knowledge on its effect on species’ thermal responses. We investigated whether changes in...

["Biodiversity","Conservation Biology","Ecology","Entomology","Climate Change Biology"]
doi:10.7717/peerj.7060

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