23 downloads
221 views

Background Differential expression analysis on the basis of RNA-Seq count data has become a standard tool in transcriptomics. Several studies have shown that prior normalization of the data is crucial for a reliable detection of transcriptional differences. Until...

["Bioinformatics","Statistics"]
doi:10.7717/peerj.3859
515 downloads
673 views

Choosing a model with too few parameters can involve making unrealistically simple assumptions and lead to high bias, poor prediction, and missed opportunities for insight. Such models are not flexible enough to describe the sample or the population well. A model...

["Statistics"]
doi:10.7287/peerj.preprints.1103v3
4,269 downloads
25,129 views

The website Sci-Hub provides access to scholarly literature via full text PDF downloads. The site enables users to access articles that would otherwise be paywalled. Since its creation in 2011, Sci-Hub has grown rapidly in popularity. However, until now, the extent...

["Bioinformatics","Legal Issues","Science and Medical Education","Statistics","Computational Science"]
doi:10.7287/peerj.preprints.3100v2
19 downloads
69 views

In daily life we are often forced to choose between the “lesser of two evils,” yet there remains limited understanding of how the brain encodes choices between aversive stimuli, particularly choices involving hypothetical futures. We tested how choice framing affects...

["Psychiatry and Psychology","Statistics"]
doi:10.7287/peerj.preprints.3340v1
47 downloads
582 views

Ecological studies often are subjected to unintentional biases, suggesting that improved research designs for hypothesis testing should be used. Double-blind ecological studies are rare but necessary to minimize sampling biases and omission errors, and improve...

["Biogeography","Ecology","Entomology","Statistics"]
doi:10.7717/peerj.3903
75 downloads
438 views

RNA-Seq is a recent and efficient technique that uses the capabilities of next-generation sequencing technology for characterizing and quantifying transcriptomes. One important task using gene-expression data is to identify a small subset of genes that can be used...

["Bioinformatics","Computational Biology","Statistics","Medical Genetics","Computational Science"]
doi:10.7717/peerj.3890
19 downloads
70 views

Celiac disease is a chronic condition, which can be described as inflammatory and autoimmune. The well-known treatment is a lifelong gluten-free diet, but it can be not totally effective for a high percentage of the patients. The aim of this work is to approach...

["Bioinformatics","Biotechnology","Computational Biology","Statistics","Computational Science"]
doi:10.7287/peerj.preprints.3315v1
39 downloads
374 views

Italian ryegrass (Lolium multiflorum) is an important cool-season, annual forage crop for the grassland rotation system in Southern China. The primary aim of breeding programs is always to seek to improve forage quality in the animal productivity system; however,...

["Agricultural Science","Biochemistry","Plant Science","Statistics"]
doi:10.7717/peerj.3867
19 downloads
206 views

Objective: The objective of this work is to obtain validity evidence for an evaluation instrument used to assess the performance level of a mastoidectomy. The instrument has been previously described and had been formulated by a multi-institutional consortium....

["Otorhinolaryngology","Surgery and Surgical Specialties","Science and Medical Education","Statistics"]
doi:10.7287/peerj.preprints.2954v2
23 downloads
113 views

Background. The Procrustean residual vector (or PAM, an acronym for the alternative equivalent term Procrustean association metric) derived from Procrustes analysis can be seen as the univariate form of relationship between two or more data tables, which provides...

["Biodiversity","Ecology","Plant Science","Soil Science","Statistics"]
doi:10.7287/peerj.preprints.3272v1
40 downloads
326 views

To improve outcomes in statistics education - namely the acquisition of statistical literacy - we need a new approach to how the subject is delivered in psychology and behavioral sciences. To do this, key indicators and impacts of barriers to learning statistics...

["Psychiatry and Psychology","Science and Medical Education","Statistics"]
doi:10.7287/peerj.preprints.3265v1
1 citation
64 downloads
280 views

Background Respondent fatigue, also known as survey fatigue, is a common problem in the collection of survey data. Factors that are known to influence respondent fatigue include survey length, survey topic, question complexity, and open-ended question type. There...

["Anaesthesiology and Pain Management","Global Health","Statistics","Human\u2013Computer Interaction"]
doi:10.7717/peerj.3785
12 downloads
209 views

Background: Drugs for dementia have been available in England from 1997. Since their launch, there have been several changes to national guidelines and initiatives that may have influenced prescribing. These include changes in National Institute for health and...

["Neuroscience","Epidemiology","Pharmacology","Statistics"]
doi:10.7287/peerj.preprints.3238v1
82 downloads
413 views

RNA sequencing (RNA-Seq) enables the measurement and comparison of gene expression with isoform-level quantification. Differences in the effect of each isoform may make traditional methods, which aggregate isoforms, ineffective. Here, we introduce a variance component-based...

["Bioinformatics","Statistics"]
doi:10.7717/peerj.3797
689 downloads
3,606 views

Within the statistics community, a number of guiding principles for sharing data have emerged; however, these principles are not always made clear to collaborators generating the data. To bridge this divide, we have established a set of guidelines for sharing data....

["Statistics","Data Science"]
doi:10.7287/peerj.preprints.3139v5

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