356 downloads
1,545 views

This essay proposes mathematical answers to meta-scientific questions including "how much knowledge is produced by research?", "how rapidly is a field making progress?", "what is the expected reproducibility of a result?", "what do we mean by soft science?", "what...

["Computational Biology","Evolutionary Studies","Science Policy","Statistics","Computational Science"]
doi:10.7287/peerj.preprints.1968v3
353 downloads
203 views

We previously reported over 150 inconsistencies in a series of four articles (the "pizza papers") from the Cornell Food and Brand Lab that described a study of eating habits at an all-you-can-eat pizza buffet. The lab's initial response led us to investigate more...

["Ethical Issues","Science Policy","Statistics"]
doi:10.7287/peerj.preprints.3025v1
654 downloads
3,426 views

The widespread use of 'statistical significance' as a license for making a claim of a scientific finding leads to considerable distortion of the scientific process (according to the American Statistical Association). We review why degrading p-values into 'significant'...

["Science Policy","Statistics"]
doi:10.7287/peerj.preprints.2921v2
58 downloads
62 views

Background. The Ebola Virus Disease (EVD) is a highly infectious disease that has claimed over 25,000 cases in the past 50 years. While many past outbreaks of EVD resulted in relatively few incidents, the 2014 outbreak in West Africa was the most deadly occurrence...

["Virology","Epidemiology","Infectious Diseases","Statistics"]
doi:10.7287/peerj.preprints.3021v1
50 downloads
233 views

Seawater temperature anomalies associated with warming climate have been linked to increases in coral disease outbreaks that have contributed to coral reef declines globally. However, little is known about how seasonal scale variations in environmental factors...

["Marine Biology","Statistics"]
doi:10.7717/peerj.3438
36 downloads
312 views

The purpose of this study was to verify a theoretical model of parents’ responses to difficulties they experienced with their child. The model presents relationships between seven variables: (a) discrepancy between parental goal and the child’s current level of...

["Mathematical Biology","Pediatrics","Psychiatry and Psychology","Statistics"]
doi:10.7717/peerj.3384
59 downloads
301 views

Site-specific evolutionary rates can be estimated from codon sequences or from amino-acid sequences. For codon sequences, the most popular methods use some variation of the dN∕dS ratio. For amino-acid sequences, one widely-used method is called Rate4Site, and it...

["Bioinformatics","Computational Biology","Evolutionary Studies","Statistics"]
doi:10.7717/peerj.3391
54 downloads
297 views

The ecological niche concept has regained interest under environmental change (e.g., climate change, eutrophication, and habitat destruction), especially to study the impacts on niche shift and conservatism. Here, we propose the within outlying mean indexes (WitOMI),...

["Biogeography","Ecology","Statistics"]
doi:10.7717/peerj.3364
46 downloads
224 views

Identifying the pathways that control a cellular phenotype is the first step to building a mechanistic model. Recent examples in developmental biology, cancer genomics, and neurological disease have demonstrated how changes in the variability of gene expression...

["Bioinformatics","Cell Biology","Statistics"]
doi:10.7717/peerj.3334
89 downloads
560 views

Background Network analysis has become a relevant approach to analyze cascading species extinctions resulting from perturbations on mutualistic interactions as a result of environmental change. In this context, it is essential to be able to point out key species,...

["Ecology","Ecosystem Science","Statistics"]
doi:10.7717/peerj.3321
158 downloads
743 views

Misconceptions about the assumptions behind the standard linear regression model are widespread and dangerous. These lead to using linear regression when inappropriate, and to employing alternative procedures with less statistical power when unnecessary. Our systematic...

["Psychiatry and Psychology","Statistics"]
doi:10.7717/peerj.3323
76 downloads
383 views

Meta analysis refers to a process of integration of the results of many studies to arrive at evidence syn- thesis. Meta analysis is similar to systematic review; however, in addition to narrative summary that is conducted in systematic review, in meta analysis,...

["Epidemiology","Evidence Based Medicine","Health Policy","Public Health","Statistics"]
doi:10.7287/peerj.preprints.2978v1
11 downloads
114 views

Objective: The objective of this work is to obtain validity evidence for an evaluation instrument used to assess the performance level of a mastoidectomy. The instrument has been previously described and had been formulated by a multi-institutional consortium....

["Otorhinolaryngology","Science and Medical Education","Statistics"]
doi:10.7287/peerj.preprints.2954v1
51 downloads
252 views

Telomere shortening has emerged as an important biomarker of aging. Longitudinal studies consistently find that, although telomere length shortens over time on average, there is a subset of individuals for whom telomere length is observed to increase. This apparent...

["Genetics","Genomics","Epidemiology","Statistics"]
doi:10.7717/peerj.3265
261 downloads
1,998 views

Background There is wide agreement in the biomedical research community that research data sharing is a primary ingredient for ensuring that science is more transparent and reproducible. Publishers could play an important role in facilitating and enforcing data...

["Ethical Issues","Science and Medical Education","Science Policy","Statistics"]
doi:10.7717/peerj.3208

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