33 downloads
294 views

Background There is wide agreement in the biomedical research community that research data sharing is a primary ingredient for ensuring that science is more transparent and reproducible. Publishers could play an important role in facilitating and enforcing data...

["Ethical Issues","Science and Medical Education","Science Policy","Statistics"]
doi:10.7717/peerj.3208
5 downloads
67 views

Background: Respondent fatigue, also known as survey fatigue, is a common problem in the collection of survey data. Factors that are known to influence respondent fatigue include survey length, survey topic, question complexity, and open-ended question type. There...

["Anaesthesiology and Pain Management","Global Health","Statistics","Human-Computer Interaction"]
doi:10.7287/peerj.preprints.2939v1
219 downloads
1,171 views

1. Stable isotope analysis is a widely used tool for the reconstruction and interpretation of animal diets and trophic relationships. Analytical tools have improved the robustness of inferring the relative contribution of different prey sources to an animal’s diet...

["Computational Biology","Ecology","Ecosystem Science","Zoology","Statistics"]
doi:10.7287/peerj.preprints.1950v3
89 downloads
419 views

The widespread use of 'statistical significance' as a license for making a claim of a scientific finding leads to considerable distortion of the scientific process (American Statistical Association, Wasserstein & Lazar 2016). We review why degrading p-values into...

["Statistics"]
doi:10.7287/peerj.preprints.2921v1
19 downloads
259 views

Pedigrees, though straightforward and versatile, lack the ability to tell us information about many individuals. Though numerical systems have been developed, there is currently no system to quantify the probability of a pedigree following certain inheritance systems....

["Bioinformatics","Genetics","Mathematical Biology","Statistics"]
doi:10.7287/peerj.preprints.2871v5
126 downloads
686 views

Drug repositioning (i.e., drug repurposing) is the process of discovering new uses for marketed drugs. Historically, such discoveries were serendipitous. However, the rapid growth in electronic clinical data and text mining tools makes it feasible to systematically...

["Bioinformatics","Clinical Trials","Drugs and Devices","Oncology","Statistics"]
doi:10.7717/peerj.3154
34 downloads
181 views

A measure of statistical evidence should permit the sample size determination so that the probability M of obtaining (strong) misleading evidence can be held as low as desired. On this desideratum the p-value fails completely, as it leads either to an arbitrary...

["Bioinformatics","Epidemiology","Statistics"]
doi:10.7287/peerj.preprints.2869v1
1 citation
113 downloads
671 views

Degeneracy in the genetic code implies that different codons can encode the same amino acid. Usage preference of synonymous codons has been observed in all domains of life. There is much evidence suggesting that this bias has a major role on protein elongation...

["Bioinformatics","Genetics","Genomics","Molecular Biology","Statistics"]
doi:10.7717/peerj.3081
40 downloads
121 views

Mutualistic communities play an important role in biodiversity preservation. They are modeled as bipartite networks and measurements of centrality and degree help to order species and their relative importance for network robustness. Identifying the most endangered...

["Ecology","Ecosystem Science","Statistics"]
doi:10.7287/peerj.preprints.2855v1
132 downloads
815 views

Head et al. (2015) provided a large collection of p-values that, from their perspective, indicates widespread statistical significance seeking (i.e., p-hacking). This paper inspects this result for robustness. Theoretically, the p-value distribution should be a...

["Science Policy","Statistics"]
doi:10.7717/peerj.3068
72 downloads
333 views

Background The macro environment we live in projects what we can achieve and how we behave, and in turn, shapes our health in complex ways. Policymaking will benefit from insights into the mechanisms underlying how national socioeconomic context affects health....

["Epidemiology","Global Health","Public Health","Statistics"]
doi:10.7717/peerj.3053
86 downloads
616 views

Wildlife collision data are ubiquitous, though challenging for making ecological inference due to typically irreducible uncertainty relating to the sampling process. We illustrate a new approach that is useful for generating inference from predator data arising...

["Conservation Biology","Ecology","Mathematical Biology","Statistics"]
doi:10.7717/peerj.3014
63 downloads
357 views

Interstitial lung disease (ILD) is a severe extra-articular manifestation of rheumatoid arthritis (RA) that is well-defined as a chronic systemic autoimmune disease. A proportion of patients with RA-associated ILD (RA-ILD) develop pulmonary fibrosis (PF), resulting...

["Immunology","Respiratory Medicine","Rheumatology","Statistics"]
doi:10.7717/peerj.3021
23 downloads
134 views

We studied the effect of linearization on the repeatability of the Tofts and reference region models (RRM) for Dynamic Contrast-Enhanced MRI (DCE MRI). We compared the repeatabilities of these two linearized models, the standard non-linear version, and semi-quantitative...

["Mathematical Biology","Radiology and Medical Imaging","Statistics"]
doi:10.7287/peerj.preprints.2824v1
62 downloads
138 views

The ecological niche concept has a revival interest under climate change, especially to study its impact on niche shift and/or conservatism. Here, we propose the Within Outlying Mean Indexes (WitOMI), which refines the Outlying Mean Index (OMI) analysis by using...

["Ecology","Statistics"]
doi:10.7287/peerj.preprints.2810v1

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