33 downloads
288 views

Previously, we revealed that several kampo medicines used for patients with excess and/or medium patterns (kakkonto (TJ-1), shosaikoto (TJ-9), hangeshashinto (TJ-14), and orento (TJ-120)) reduced prostaglandin (PG)E2 levels using LPS-treated human gingival fibroblasts...

["Cell Biology","Dentistry","Pharmacology"]
doi:10.7717/peerj.4120
34 downloads
411 views

A recurrent question within oncology drug development is predicting phase III outcome for a new treatment using early clinical data. One approach to tackle this problem has been to derive metrics from mathematical models that describe tumour size dynamics termed...

["Mathematical Biology","Clinical Trials","Oncology","Pharmacology","Statistics"]
doi:10.7717/peerj.4111
57 downloads
454 views

Ginsenoside Rk1 (G-Rk1) is a unique component created by processing the ginseng plant (mainly Sung Ginseng (SG)) at high temperatures. The aim of our study was to systematically review the pharmacological effects of G-Rk1. We utilized and manually searched eight...

["Plant Science","Evidence Based Medicine","Pharmacology"]
doi:10.7717/peerj.3993
83 downloads
534 views

Cancers have killed millions of people in human history and are still posing a serious health problem worldwide. Therefore, there is an urgent need for developing preventive and therapeutic cancer vaccines. Among various cancer vaccine development platforms, virus-like...

["Immunology","Pharmacology"]
doi:10.7717/peerj.4053
77 downloads
352 views

Background Self-medication refers to the use of medicines to treat self-diagnosed diseases without consulting any healthcare professionals. Irrational drug use and self-medication have serious negative consequences both on health and economy. Therefore, the aim...

["Epidemiology","Pharmacology","Public Health"]
doi:10.7717/peerj.3990
33 downloads
235 views

Previously, we revealed that several kampo medicines that are used for patients with excess and/or medium patterns [kakkonto (TJ-1), shosaikoto (TJ-9), hangeshashinto (TJ-14), and orento (TJ-120)] reduced prostaglandin (PG)E<2 levels using LPS-treated human gingival...

["Cell Biology","Dentistry","Pharmacology"]
doi:10.7287/peerj.preprints.3227v2
138 downloads
809 views

Introduction The repurposing of non-antibiotic drugs as adjuvant antibiotics may help break antimicrobial resistance (AMR). Statins are commonly prescribed worldwide to lower cholesterol. They also possess qualities of AMR “breakers”, namely direct antibacterial...

["Microbiology","Drugs and Devices","Global Health","Infectious Diseases","Pharmacology"]
doi:10.7717/peerj.3952
134 downloads
482 views

Clinical evidence points to neuroprotective effects of smoking in Parkinson’s disease (PD), but the molecular mechanisms remain unclear. We investigated the pharmacological pathways involved in these neuroprotective effects, which could provide novel ideas for...

["Biochemistry","Molecular Biology","Neuroscience","Neurology","Pharmacology"]
doi:10.7717/peerj.3933
14 downloads
122 views

Background. Microdialysis is a valued method to study the pharmacokinetics of drug distribution from an injection site or to a tumor site. The objective of this study was to assess the feasibility of prolonged use of subcutaneously implanted microdialysis catheters...

["Drugs and Devices","Oncology","Pharmacology"]
doi:10.7287/peerj.preprints.3324v1
71 downloads
161 views

Backgroud. Mercuric sulfide (HgS) has been used in traditional medicines for thousands of years, such as cinnabar, Zuotai and so on. Increasing research supports that HgS is different from mercury chloride (HgCl2) and methylmercury (MeHg) in toxicity and pharmacology,...

["Toxicology","Pharmacology"]
doi:10.7287/peerj.preprints.3308v1
98 downloads
486 views

Background The rapid increase in antibiotic resistance by various bacterial pathogens underlies the significance of developing new therapies and exploring different drug targets. A fraction of bacterial pathogens abbreviated as ESKAPE by the European Center for...

["Bioinformatics","Computational Biology","Microbiology","Pharmacology"]
doi:10.7717/peerj.3765
110 downloads
430 views

Background High mobility group box 1 (HMGB1) is a well-known damage-related alarmin that participates in cellular inflammatory responses. However, the mechanisms leading to HMGB1 release in inflammatory conditions and the therapeutic agents that could prevent it...

["Biotechnology","Toxicology","Drugs and Devices","Evidence Based Medicine","Pharmacology"]
doi:10.7717/peerj.3808
193 downloads
487 views

Background Awareness about antibiotic resistance depends on the attitudes and information about antibiotic resistance of both patients and physicians. Persons who practice self-medication are at high risk of also self-medicating with antibiotics. The purpose of...

["Health Policy","Pharmacology"]
doi:10.7717/peerj.3803
15 downloads
266 views

Background: Drugs for dementia have been available in England from 1997. Since their launch, there have been several changes to national guidelines and initiatives that may have influenced prescribing. These include changes in National Institute for health and...

["Neuroscience","Epidemiology","Pharmacology","Statistics"]
doi:10.7287/peerj.preprints.3238v1
125 downloads
461 views

Angiogenesis is an important factor contributing to the radioresistance of lung cancer. However, the associated mechanisms underlying radiotherapy-induced pro-angiogenesis are unclear. Here, we demonstrated that Extracellular vesicles (EVs) derived from cultured...

["Pharmacology"]
doi:10.7717/peerj.3627

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