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Total of 143 results See all subject areas
infectious diseases

Evolutionary studies of clustered regularly interspaced short palindromic repeats (CRISPRs) and their associated (cas) genes can provide insights into host-pathogen co-evolutionary dynamics and the frequency at which different genomic events (e.g., horizontal vs....

["Evolutionary Studies","Genomics","Microbiology","Infectious Diseases"]
doi:10.7717/peerj.340

Background. While often first treated in the emergency department (ED), identification of sepsis is difficult. Electronic medical record (EMR) clinical decision tools offer a novel strategy for identifying patients with sepsis. The objective of this study was to...

["Emergency and Critical Care","Infectious Diseases","Public Health"]
doi:10.7717/peerj.343

Testing for cytomegalovirus (CMV) DNA is increasingly being used for specimen types other than plasma or whole blood. However, few studies have investigated the performance of different nucleic acid extraction protocols in such specimens. In this study, CMV extraction...

["Infectious Diseases","Pathology"]
doi:10.7717/peerj.334

Caenorhabditis elegans is commonly used as an infection model for pathogenesis studies in Pseudomonas aeruginosa. While the standard virulence assays rely on the slow and fast killing or paralysis of nematodes, here we developed a behaviour assay to monitor the...

["Microbiology","Infectious Diseases"]
doi:10.7287/peerj.preprints.313v1

Overview. The Centers for Disease Control and Prevention (CDC) health-related quality of life (HRQoL) indicators are widely used in the general population to determine the burden of disease, identify health needs, and direct public health policy. These indicators...

["Epidemiology","Infectious Diseases","Statistics"]
doi:10.7717/peerj.322

HIV disclosure from parent to child is complex and challenging to HIV-positive parents and healthcare professionals. This study was conducted to understand the lived experiences of HIV-positive parents and their children during the disclosure process in Kenya....

["Epidemiology","Global Health","HIV","Infectious Diseases","Public Health"]
doi:10.7287/peerj.preprints.303v1

Chronic wounds are a major global health problem. Their management is difficult and costly, and the development of antibiotic resistance by both planktonic and biofilm-associated bacteria necessitates the use of alternative wound treatments. Honey is now being...

["Microbiology","Infectious Diseases"]
doi:10.7717/peerj.326

In low- and middle-income countries, the attrition across the continuum of care of HIV infected children is not well known. The aim of this study was to investigate predictors of mortality and loss to follow up (LTFU) in HIV infected children from a cohort study...

["HIV","Infectious Diseases","Pediatrics"]
doi:10.7717/peerj.304

Mycobacterium species have a complex cAMP regulatory network indicated by the high number of adenylate cyclases annotated in their genomes. However the need for a high level of redundancy in adenylate cyclase genes remains unknown. We have used semiquantitiative...

["Microbiology","Infectious Diseases"]
doi:10.7717/peerj.298

In many biological applications, we would like to be able to computationally predict mutational effects on affinity in protein–protein interactions. However, many commonly used methods to predict these effects perform poorly in important test cases. In particular,...

["Biochemistry","Biophysics","Computational Biology","Virology","Infectious Diseases"]
doi:10.7717/peerj.266

Recent scientific discoveries lead inexorably to the conclusion that the ‘total human’ incorporates a necessary body of numerous microbes, including bacteria. These bacteria play a very important role in immunity by actively resisting infections by outside bacteria;...

["Ecology","Microbiology","Infectious Diseases"]
doi:10.7287/peerj.preprints.236v1

In many biological applications, we would like to be able to computationally predict mutational effects on affinity in protein-­protein interactions. However, many commonly used methods to predict these effects perform poorly in important test cases. In particular,...

["Biochemistry","Biophysics","Computational Biology","Virology","Infectious Diseases"]
doi:10.7287/peerj.preprints.138v3

Mycobacterium species have a complex cAMP regulatory network indicated by the high number of adenylate cyclases annotated in their genomes. However the need for a high level of redundancy in adenylate cyclase genes remains unknown. We have used semiquantitiative...

["Microbiology","Infectious Diseases"]
doi:10.7287/peerj.preprints.177v1

Motivation. Predominant pathway analysis approaches treat pathways as collections of individual genes and consider all pathway members as equally informative. As a result, at times spurious and misleading pathways are inappropriately identified as statistically...

["Bioinformatics","Computational Biology","Molecular Biology","Immunology","Infectious Diseases"]
doi:10.7717/peerj.229

All strategies to prevent Pneumocystis jiroveci pneumonia (PCP) during rituximab treatment have their rationale in patients with granulomatosis with polyangiitis (GPA) and to some extent in patients with other autoimmune diseases (AID). Risk factors of PCP and...

["Allergy and Clinical Immunology","Infectious Diseases","Internal Medicine","Respiratory Medicine","Rheumatology"]
doi:10.7287/peerj.preprints.149v1

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