25 downloads
338 views

The past two decades have brought many important advances in our understanding of the hereditary susceptibility to cancer. Numerous studies have provided convincing evidence that identification of germline mutations associated with hereditary cancer syndromes can...

["Genomics","Oncology","Medical Genetics"]
doi:10.7717/peerj.3046
5 downloads
69 views

Microorganism is an important part of ecosystems; it is very sensitive to environmental change. In order to study the effects of sound on organisms, it’s meaningful to study mechanism of microbial exposure to sound. In our previous experiments, the effects of different...

["Genomics","Microbiology"]
doi:10.7287/peerj.preprints.2821v1
27 downloads
91 views

Aerobic anoxygenic phototrophic bacteria (AAPB) containing bacteriochlorophyll a (BChl a) are photoheterotrophic prokaryotes that are a widely distributed functional bacterial group due to their obligately aerobic and facultative photoheterotrophic abilities. Here,...

["Ecology","Environmental Sciences","Genomics","Marine Biology","Microbiology"]
doi:10.7287/peerj.preprints.2820v1
143 downloads
685 views

Background De novo transcriptome assembly of short reads is now a common step in expression analysis of organisms lacking a reference genome sequence. Several software packages are available to perform this task. Even if their results are of good quality it is...

["Bioinformatics","Computational Biology","Genomics","Computational Science"]
doi:10.7717/peerj.2988
61 downloads
580 views

Genomic heterogeneity of bacterial species is observed and studied in experimental evolution experiments and clinical diagnostics, and occurs as micro-diversity of natural habitats. The challenge for genome research is to accurately capture this heterogeneity with...

["Bioinformatics","Computational Biology","Evolutionary Studies","Genomics","Microbiology"]
doi:10.7717/peerj.2997
80 downloads
355 views

Streptomyces sp. H-KF8 is an actinobacterial strain isolated from marine sediments of a Chilean Patagonian fjord. Morphological characterization together with antibacterial activity was assessed in various culture media, revealing a carbon-source dependent activity...

["Genomics","Microbiology"]
doi:10.7717/peerj.2912
58 downloads
236 views

Background The endemic Australian freshwater prawn, Macrobrachium koombooloomba, provides a model for exploring genes involved with freshwater adaptation because it is one of the relatively few Macrobrachium species that can complete its entire life cycle in freshwater....

["Aquaculture, Fisheries and Fish Science","Evolutionary Studies","Genomics","Marine Biology"]
doi:10.7717/peerj.2977
8 downloads
76 views

Basic idea of science is reproducibility of phenomena and experiments. Reproducibility of data analyses and reports is becoming more and more important. It requires structured organization of data, augmented with enought metadata for future re-use of data. Our...

["Bioinformatics","Genomics","Plant Science","Statistics","Computational Science"]
doi:10.7287/peerj.preprints.2791v1
689 downloads
512 views

Divergence of treatment responses to chemotherapy exists across patients (often with unknown underlying mechanisms), with some patients exhibiting worsened outcome upon treatment. Genomic approaches (such as microarray profiling and whole genome sequencing) hold...

["Bioengineering","Bioinformatics","Cell Biology","Genomics","Histology"]
doi:10.7287/peerj.preprints.1049v6
22 downloads
78 views

American trypanosomiasis is a chronic and endemic disease, which affects millions of people. Trypanosoma cruzi, its causative agent, has a life cycle that involves complex morphological and functional transitions, as well as a variety of environmental conditions....

["Biochemistry","Genomics","Molecular Biology","Parasitology","Infectious Diseases"]
doi:10.7287/peerj.preprints.2782v1
22 downloads
212 views

Introduction 2nd generation sequencing or better known as next-generation sequencing (NGS) represents a cutting-edge technology in life sciences and current foundation for unravelling nucleotide sequences. Since advent of first platforms in 2005 the number of different...

["Bioinformatics","Biotechnology","Genomics","Molecular Biology"]
doi:10.7287/peerj.preprints.2771v1
52 downloads
204 views

Background RNA sequencing (RNA-Seq) is a powerful technique for transcriptome profiling of the organisms that uses the capabilities of next-generation sequencing (NGS) technologies. Recent advances in NGS let to measure the expression levels of tens to thousands...

["Bioinformatics","Genomics","Statistics","Computational Science"]
doi:10.7287/peerj.preprints.2761v1
92 downloads
773 views

A high-quality draft genome for Proctacanthus coquilletti (Insecta: Diptera: Asilidae) is presented along with transcriptomes for 16 Diptera species from five families: Asilidae, Apioceridae, Bombyliidae, Mydidae, and Tabanidae. Genome sequencing reveals that P....

["Entomology","Genomics"]
doi:10.7717/peerj.2951
55 downloads
245 views

Background Multiple myeloma is a cancer which has a high occurrence rate and causes great injury to people worldwide. In recent years, many studies reported the effects of miRNA on the appearance of multiple myeloma. However, due to the differences of samples and...

["Genomics","Dermatology","Oncology"]
doi:10.7717/peerj.2831
23 downloads
88 views

The human male specific Y-chromosome passes from father to son essentially unchanged, but occasionally a random change, known as a mutation, occurs. These mutations, also called markers, serve as beacons and can be mapped. When geneticists identify a mutation in...

["Anthropology","Genetics","Genomics"]
doi:10.7287/peerj.preprints.2755v1

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