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genomics
12 downloads
15 views

Recently, a number of protocols extending RNA-sequencing to the single-cell regime have been published. However, we were concerned that the additional steps to deal with such minute quantities of input sample would introduce serious biases that would make analysis...

["Bioinformatics","Biotechnology","Computational Biology","Genomics"]
doi:10.7717/peerj.869
32 downloads
82 views

The perilipins are lipid droplet surface proteins that contribute to fat metabolism by controlling the access of lipids to lipolytic enzymes. Perilipins have been identified in organisms as diverse as metazoa, fungi, and amoebas but strikingly not in nematodes....

["Bioinformatics","Cell Biology","Genomics"]
doi:10.7287/peerj.preprints.904v2
70 downloads
157 views

Amplifications or deletions of genome segments, known as copy number variants (CNVs), have been associated with many diseases. Read depth analysis of next-generation sequencing (NGS) is an essential method of detecting CNVs. However, genome read coverage is frequently...

["Bioinformatics","Computational Biology","Genomics"]
doi:10.7717/peerj.836
64 downloads
195 views

Summary: HapFlow is a python application for visualising haplotypes present in high-throughput sequencing data. HapFlow identifies nucleotide variant profiles in raw read sequences and creates an abstract visual representation of these profiles to make haplotypes...

["Bioinformatics","Genomics","Microbiology"]
doi:10.7287/peerj.preprints.895v1
675 downloads
5,526 views

Although brain imaging studies have demonstrated that listening to music alters human brain structure and function, the molecular mechanisms mediating those effects remain unknown. With the advent of genomics and bioinformatics approaches, these effects of music...

["Genetics","Genomics"]
doi:10.7717/peerj.830
78 downloads
118 views

Alternative splicing enables a single gene to produce multiple mRNA isoforms by varying splice site selection. In animals, alternative splicing of mRNA isoforms between cell types is widespread and supports cellular differentiation. In plants, at least 20% of multi-exon...

["Agricultural Science","Bioinformatics","Genomics","Molecular Biology","Plant Science"]
doi:10.7287/peerj.preprints.594v2
41 downloads
278 views

Calorie restriction is known to extend lifespan among organisms by a debating mechanism underlying nitric oxide-driven mitochondrial biogenesis. We report here that nitric oxide generators including artemisinin, sodium nitroprusside, and L-arginine mimics calorie...

["Biochemistry","Genomics","Pharmacology"]
doi:10.7717/peerj.822
83 downloads
327 views

Neisseria gonorrhoeae is the causative agent of gonorrhea, a sexually transmitted infection (STI) of major importance. As a result of antibiotic resistance, there are now limited options for treating patients. We collected draft genome sequence data and associated...

["Bioinformatics","Evolutionary Studies","Genomics","Microbiology","Infectious Diseases"]
doi:10.7717/peerj.806
34 downloads
51 views

Substantial health disparities exist between African Americans and Caucasians in the United States. Copy number variations (CNVs) are one form of human genetic variations that have been linked with complex diseases and often occur at different frequencies among...

["Bioinformatics","Genetics","Genomics"]
doi:10.7717/peerj.677
52 downloads
322 views

When computing alignments of DNA sequences to a large genome, a key element in achieving high processing throughput is to prioritize locations in the genome where high-scoring mappings might be expected. We formulated this task as a series of list-processing operations...

["Bioinformatics","Genomics","Computational Science"]
doi:10.7717/peerj.808
103 downloads
383 views

Background. Most genetic disorders are caused by single nucleotide variations (SNVs) or small insertion/deletions (indels). High throughput sequencing has broadened the catalogue of human variation, including common polymorphisms, rare variations or disease causing...

["Bioinformatics","Genetics","Genomics"]
doi:10.7717/peerj.796
161 downloads
298 views

Comparing inferences among datasets generated using short read sequencing may provide insight into the concerted effects of evolutionary processes across organisms, but comparisons are complicated by biases introduced during dataset assembly. Sequence similarity...

["Bioinformatics","Evolutionary Studies","Genetics","Genomics","Molecular Biology"]
doi:10.7287/peerj.preprints.864v1
73 downloads
219 views

Background. Studies of ancestry are difficult in the tomato because it crosses with many wild relatives and species in the tomato clade that have diverged very recently. As a result, the phylogeny in relation to its closest relatives remains uncertain. By using...

["Agricultural Science","Bioinformatics","Evolutionary Studies","Genomics","Plant Science"]
doi:10.7717/peerj.793
69 downloads
128 views

Culex pipiens, an invasive mosquito and vector of West Nile virus in the US, has two morphologically indistinguishable forms that differ dramatically in behavior and physiology. Cx. pipiens form pipiens is primarily a bird-feeding temperate mosquito, while the...

["Entomology","Evolutionary Studies","Genomics","Taxonomy"]
doi:10.7717/peerj.807
56 downloads
304 views

CITED1 is a non-DNA binding transcriptional co-regulator whose expression can distinguish the ‘proliferative’ from ‘invasive’ signature in the phenotype-switching model of melanoma. We have found that, in addition to other ‘proliferative’ signature genes, CITED1...

["Bioinformatics","Cell Biology","Genomics","Molecular Biology"]
doi:10.7717/peerj.788

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