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genetics
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Background. Most genetic disorders are caused by single nucleotide variations (SNVs) or small insertion/deletions (indels). High throughput sequencing has broadened the catalogue of human variation, including common polymorphisms, rare variations or disease causing...

["Bioinformatics","Genetics","Genomics"]
doi:10.7717/peerj.796
1 download

Background. To cope with their natural enemies, plants rely on resistance and tolerance as defensive strategies. Evolution of these strategies among natural population can be constrained by the absence of genetic variation or because of the antagonistic genetic...

["Ecology","Evolutionary Studies","Genetics"]
doi:10.7717/peerj.789
72 downloads
173 views

Comparing inferences among datasets generated using short read sequencing may provide insight into the concerted effects of evolutionary processes across organisms, but comparisons are complicated by biases introduced during dataset assembly. Sequence similarity...

["Bioinformatics","Evolutionary Studies","Genetics","Genomics","Molecular Biology"]
doi:10.7287/peerj.preprints.864v1
4 downloads
12 views

Adaptation to pollinators is a key factor of diversification in angiosperms. The Caribbean sister genera Rhytidophyllum and Gesneria present an important diversification of floral characters. Most of their species can be divided in two major pollination syndromes....

["Biodiversity","Evolutionary Studies","Genetics","Plant Science"]
doi:10.7287/peerj.preprints.861v1
18 downloads
27 views

Elucidating the genomic diversity of CD209 gene promoter polymorphism could assist in clarifying disease pathophysiology as well as contribution to co-morbidities. CD209 gene promoter polymorphism has been shown to be associated with susceptibility to infection....

["Evolutionary Studies","Genetics","Molecular Biology","Hematology"]
doi:10.7717/peerj.799
30 downloads
115 views

High-fecundity organisms, such as Atlantic cod, can withstand substantial natural selection and the entailing genetic load of replacing alleles at a number of loci due to their excess reproductive capacity. High-fecundity organisms may reproduce by sweepstakes...

["Aquaculture, Fisheries and Fish Science","Biogeography","Evolutionary Studies","Genetics","Marine Biology"]
doi:10.7717/peerj.786
51 downloads
71 views

In Drosophila melanogaster, the male-specific lethal (MSL) complex has been studied extensively for its role in upregulating male X-linked genes. Recent advances in high-throughput technologies have improved our understanding of how the MSL complex mediates dosage...

["Computational Biology","Genetics","Genomics"]
doi:10.7717/peerj.771
41 downloads
129 views

The post-genomic era is characterized by the direct acquisition and analysis of genomic data with many applications, including the enhancement of the understanding of microbial epidemiology and pathology. However, there are a number of molecular approaches to survey...

["Biodiversity","Evolutionary Studies","Genetics","Genomics","Epidemiology"]
doi:10.7717/peerj.761
23 downloads
90 views

The ability of Shiga toxin-producing Escherichia coli (STEC) to cause severe illness in humans is determined by multiple host factors and bacterial characteristics, including Shiga toxin (Stx) subtype. Given the link between Stx2a subtype and disease severity,...

["Bioinformatics","Genetics","Genomics","Microbiology"]
doi:10.7717/peerj.739
169 downloads
314 views

Recent advances in CRISPR-Cas9 genome editing tool have made great promises to basic and biomedical research as well as gene therapy. Efforts to make the CRISPR-Cas9 system applicable in gene therapy are largely focused on two aspects: 1) increasing the specificity...

["Cell Biology","Genetics","Molecular Biology"]
doi:10.7287/peerj.preprints.818v3
53 downloads
41 views

The origin of recent parallel outbreaks of the high pathogenicity H5N8 avian flu virus in Europe and in Japan can be traced to a single source population, which has most likely been spread by migratory birds. By using Bayesian coalescence methods to analyze the...

["Agricultural Science","Bioinformatics","Computational Biology","Genetics","Virology"]
doi:10.7287/peerj.preprints.822v1
52 downloads
168 views

Nephila clavata L Koch, known as the Joro spider and native to East Asia (Japan, China, Korea, and Taiwan), is newly reported from North America. Specimens from several locations in northeast Georgia were collected from around residential properties in Barrow,...

["Ecology","Entomology","Genetics","Taxonomy","Coupled Natural and Human Systems"]
doi:10.7717/peerj.763
29 downloads
168 views

Human alteration of islands has made restoration a key part of conservation management. As islands are restored to their original state, species interactions change and some populations may be impacted. In this study we examine the coxella weevil, (Hadramphus spinipennis...

["Conservation Biology","Entomology","Genetics"]
doi:10.7717/peerj.749
117 downloads
80 views

One of the very few snail taxa that display genetic antisymmetry (that is, roughly equal mixes of genetically determined clockwise [D] and anticlockwise [S] coiled individuals within a single population) are the circa 35 species of the tropical tree snail subgenus...

["Ecology","Evolutionary Studies","Genetics","Zoology"]
doi:10.7287/peerj.preprints.470v2
24 downloads
112 views

Myxococcus xanthus displays a form of surface motility known as social (S) gliding. It is mediated by the type IV pilus (T4P) and requires the exopolysaccharide (EPS) to function. It is clear that T4P retraction powers S motility. EPS on a neighboring cell or deposited...

["Developmental Biology","Genetics","Microbiology","Molecular Biology"]
doi:10.7717/peerj.747

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