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genetics
2 downloads
11 views

Motivations. Building the Burrows-Wheeler transform (BWT) and computing the Lempel-Ziv parsing (LZ77) of huge collections of genomes is becoming an important task in bioinformatic analyses as these datasets often need to be compressed and indexed prior to analysis....

["Bioinformatics","Computational Biology","Genetics","Computational Science"]
doi:10.7287/peerj.preprints.2176v1
8 downloads
190 views

Supertree methods combine a set of phylogenetic trees into a single supertree. Similar to supermatrix methods, these methods provide a way to reconstruct larger parts of the Tree of Life, potentially evading the computational complexity of phylogenetic inference...

["Bioinformatics","Computational Biology","Evolutionary Studies","Genetics","Taxonomy"]
doi:10.7717/peerj.2172
14 downloads
151 views

Hereditary breast and ovarian cancer syndrome, caused by a germline pathogenic variant in the BRCA1 or BRCA2 (BRCA1/2) genes, is characterized by an increased risk for breast, ovarian, pancreatic and other cancers. Identification of those who have a BRCA1/2 mutation...

["Genetics","Genomics","Oncology","Women\u2019s Health"]
doi:10.7717/peerj.2162
7 downloads
77 views

WRKY proteins are the plant-specific zinc finger transcription factors. They can specifically interact with the W-box ([C/T]TGAC[T/C]), which can be found in the promoter region of a large number of plant target genes, to regulate the expressions of downstream...

["Genetics","Plant Science"]
doi:10.7287/peerj.preprints.2167v1
21 downloads
171 views

Background: Low-grade chronic inflammation is a common feature of obesity and its cardio-metabolic complications. However, little is known about a possible causal role of inflammation in metabolic disorders. Mexico is among the countries with the highest obesity...

["Genetics","Cardiology","Diabetes and Endocrinology","Pediatrics"]
doi:10.7717/peerj.2090
4 downloads
49 views

An abnormal polyglutamine (polyQ) expansion in the N-terminal fragment of the Huntingtin (Htt) protein leads to the devastating neurodegenerative disorder Huntington’s disease (HD). Htt is ubiquitous both at the tissue and subcellular levels and is fundamental...

["Biochemistry","Bioinformatics","Computational Biology","Genetics","Cognitive Disorders"]
doi:10.7287/peerj.preprints.2148v1
57 downloads
595 views

Background. Genome-wide association studies have succeeded in detecting novel common variants which associate with complex diseases. As a result of the fast changes in next generation sequencing technology, a large number of sequencing data are generated, which...

["Bioinformatics","Genetics","Statistics"]
doi:10.7717/peerj.2139
98 downloads
333 views

Background: The Atlantic Forest is globally one of the priority ecoregions for biodiversity conservation. In Argentina, it is represented by the Paranense Forest, which covers a vast area of Misiones Province between the Paraná and Uruguay rivers. The Uruguay River...

["Biodiversity","Conservation Biology","Genetics","Taxonomy","Zoology"]
doi:10.7717/peerj.2138
46 downloads
245 views

Background. The GNPDA2 (glucosamine-6-phosphate deaminase 2) gene is a member of Glucosamine-6-phosphate (GlcN6P) deaminase subfamily, which encoded an allosteric enzyme of GlcN6P. Genome-wide association studies (GWAS) have shown that variations of human GNPDA2...

["Genetics","Zoology"]
doi:10.7717/peerj.2129
87 downloads
583 views

1) DNA metabarcoding is a powerful tool to assess biodiversity by amplifying and sequencing a standardized gene marker region. However, typically used barcoding genes, such as the cytochrome c oxidase subunit I (COI) region for animals, are highly variable. Thus,...

["Biodiversity","Bioinformatics","Ecology","Genetics","Molecular Biology"]
doi:10.7287/peerj.preprints.2044v2
35 downloads
299 views

Gene expression is a complex and quantitative trait that is influenced by both genetic and non-genetic regulators including environmental factors. Evaluating the contribution of environment to gene expression regulation and identifying which genes are more likely...

["Bioinformatics","Genetics","Genomics"]
doi:10.7717/peerj.2123
24 downloads
169 views

Across indepedent cancer genomes it has been observed that some sites have been recurrently hit by single nucleotide variants (SNVs). Such recurrently hit sites might be either i) drivers of cancer that are postively selected during oncogenesis, ii) due to mutation...

["Bioinformatics","Computational Biology","Genetics","Genomics"]
doi:10.7287/peerj.preprints.2089v1
12 downloads
59 views

Environmental stresses select for suitably adapted genes. These stresses will promote the propagation of certain mutations, and the loss of others, throughout the evolution of a species. For organisms living two thousand meters below the ocean’s surface, one of...

["Genetics","Genomics","Marine Biology","Microbiology","Molecular Biology"]
doi:10.7287/peerj.preprints.2071v1
89 downloads
301 views

Mauremys reevesii (Geoemydidae) is one of the most common and widespread semi-aquatic turtles in East Asia. The unusually long lifespan of some individuals makes this turtle species a potentially useful model organism for studying the molecular basis of longevity....

["Genetics","Genomics","Zoology"]
doi:10.7717/peerj.2062
69 downloads
384 views

Cinnamoyl-CoA reductase (CCR) is the first enzyme in the monolignol-specific branch of the lignin biosynthetic pathway. In this research, three sorghum CCR genes including SbCCR1, SbCCR2-1 and SbCCR2-2 were cloned and characterized. Analyses of the structure and...

["Agricultural Science","Genetics","Molecular Biology"]
doi:10.7717/peerj.2005

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